A5063065014- Cancer Treatment and Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Plant-based Medicinal Research
- Acute Ischemic Stroke Management
- Cancer-related cognitive impairment studies
- Cholinesterase and Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Myasthenia Gravis and Thymoma
- Pain Mechanisms and Treatments
- Plant Physiology and Cultivation Studies
- Chemotherapy-related skin toxicity
- Metabolomics and Mass Spectrometry Studies
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Plant Growth Enhancement Techniques
- Ovarian cancer diagnosis and treatment
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Telemedicine and Telehealth Implementation
- Computational Drug Discovery Methods
Georgia Institute of Technology
2016-2024
Cancer Research Center
2023-2024
Signo Motus (Italy)
2024
Georgia State University
2015-2018
Manchester University
1952-1958
University of Manchester
1953-1958
Research Article| September 01 1956 Some chemical and physiological properties of 3-indolylpyruvic acid J. A. Bentley; Bentley 1Departments Chemistry Botany, Manchester University Search for other works by this author on: This Site PubMed Google Scholar K. R. Farrar; Farrar S. Housley; Housley G. F. Smith; Smith W. C. Taylor Biochem J (1956) 64 (1): 44–49. https://doi.org/10.1042/bj0640044 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook...
Despite decades of research, we lack a mechanistic framework capable predicting how movement-related signals are transformed into the diversity muscle spindle afferent firing patterns observed experimentally, particularly in naturalistic behaviors. Here, biophysical model demonstrates that well-known characteristics mammalian Ia afferents – including movement history dependence, and nonlinear scaling with stretch velocity emerge from first principles contractile mechanics. Further,...
Peripheral neurotoxicity is a debilitating condition that afflicts up to 90% of patients with colorectal cancer receiving oxaliplatin-containing therapy. Although emerging evidence has highlighted the importance various solute carriers toxicity anticancer drugs, contribution these proteins oxaliplatin-induced peripheral remains controversial. Among candidate transporters investigated in genetically engineered mouse models, we provide for critical role organic cation transporter 2 (OCT2)...
<h2>Abstract</h2><h3>Objective</h3> The identification/development of a machine learning-based classifier that utilizes metabolic profiles serum samples to accurately identify individuals with ovarian cancer. <h3>Methods</h3> Serum collected from 431 cancer patients and 133 normal women at four geographic locations were analyzed by mass spectrometry. Reliable metabolites identified using recursive feature elimination coupled repeated cross-validation used develop consensus able distinguish...
Journal Article Studies on Plant Growth Hormones: I. BIOLOGICAL ACTIVITIES OF 3-INDOLYLACETALDEHYDE AND 3-INDOLYLACETONITRILE Get access J. A. BENTLEY, BENTLEY Department of Botony, Manchester University Search for other works by this author on: Oxford Academic PubMed Google Scholar S. HOUSLEY Experimental Botany, Volume 3, Issue September 1952, Pages 393–405, https://doi.org/10.1093/jxb/3.3.393 Published: 01 1952 history Received: 05 January Revision received: May
For the constellation of neurologic disorders known as chemotherapy-induced peripheral neuropathy, mechanistic understanding and treatment remain deficient. Here, we present first evidence that chronic sensory neuropathy depends on nonlinear interactions between cancer chemotherapy. Global transcriptional profiling dorsal root ganglia revealed differential expression, notably in regulators neuronal excitability, metabolism, inflammatory responses, all which were unpredictable from effects...
As the population aged 65 and older grows, it becomes imperative for health care providers to expand their knowledge regarding geriatric conditions concerns. Dementia is a devastating degenerative disease process that affecting millions of individuals in United States, with significant economic emotional burden on family caregivers. The need further dementia education physical therapy school essential improve attitudes treatment affect patient outcomes quality care. This program implemented...
Balance of motor network activity between the two brain hemispheres after stroke is crucial for functional recovery. Several studies have extensively studied role affected hemisphere to better understand changes in following stroke. Very few examined unaffected and confirmed test-retest reliability connectivity measures on hemisphere. We recorded blood oxygenation level dependent magnetic resonance imaging (fMRI) signals from nine survivors with hemiparesis left or right hand. Participants...
Journal Article Studies in Plant Growth Hormones: V. CHROMATOGRAPHY OF HORMONES IN EXCISED AND INTACT ROOTS TOMATO SEEDLINGS Get access G. BRITTON, BRITTON Department of Botany, Manchester University Search for other works by this author on: Oxford Academic PubMed Google Scholar S. HOUSLEY, HOUSLEY J. A. BENTLEY Experimental Volume 7, Issue 2, 1956, Pages 239–251, https://doi.org/10.1093/jxb/7.2.239 Published: 01 July 1956 history Received: 21 October 1955
Journal Article Studies on Plant-Growth Hormones: VI. THE NATURE OF INHIBITOR-β IN POTATO Get access S. HOUSLEY, HOUSLEY Departments of Botany and Chemistry, Manchester University Search for other works by this author on: Oxford Academic PubMed Google Scholar W. C. TAYLOR Experimental Botany, Volume 9, Issue 3, October 1958, Pages 458–471, https://doi.org/10.1093/jxb/9.3.458 Published: 01 1958 history Received: 03 March
Previous reports that Michaelis enzyme kinetics may be applied to the system controlling cell elongation in Avena coleoptiles are confirmed. Substrate (applied hormone) and not direct contact with each other. Active transport of hormone coleoptile sections, permeability cells hormone, regulate intracellular substrate concentration, thereby markedly influencing value K5, a parameter giving measure affinity for enzyme. The effect factors on calculating K1 values competitive inhibitors is...
1. Acid and neutral ethereal fractions the non-ether-soluble aqueous fraction of an extract cabbage leaves were chromatographed, chromatc-grams assayed using oat coleoptile sections. 2. In acidic precursor 3-indolylacetonitrile (IAN) was found. When chromatographed in iso propanol/ammonia, travelled at position 3-indolylacetic acid (IAA), but n-butanol/ammonia it much closer to starting-line. IAN is liberated from under conditions alkaline hydrolysis including ammoniacal chromatography, also...
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a frequent adverse event of colorectal cancer treatment. OIPN encompasses chronic and an acute syndrome. The latter consists transient axonal hyperexcitability, due to unbalance in Na+ voltage-operated channels (Na+VOC). This leads sustained depolarisation which can activate the reverse mode Na+/Ca2+ exchanger 2 (NCX2), resulting toxic Ca2+ accumulation damage (ADa). We explored role NCX2 vitro vivo settings. Embryonic rat Dorsal...
Stroke survivors with severe upper limb (UL) impairment face years of therapy to recover function. Robot-assisted (RT) is increasingly used in the field for goal-oriented rehabilitation as a means improve function ULs. To be effectively wrist and hand therapy, current RT systems require patient have minimal active range movement UL, those that do not voluntary cannot use these systems. We overcome this limitation by harnessing tongue motion allow patients control robot using synchronous...
The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability. Like other neuron types, alpha motoneurons in the mammalian spinal cord express heterogeneity plasticity AIS geometry, including length (AIS l ) distance from soma d ). present study aimed to establish relationship of geometry measure intrinsic excitability, rheobase current, by 20-fold or more among normal motoneurons. We began...
Injury that severs peripheral nerves often results in long-lasting motor behavioral deficits and reorganization of related spinal circuitry, neither which reverse even after nerve regeneration. Stretch areflexia gait ataxia, for example, emerge from a combination factors including degeneration Ia-motoneuron synapses between peripherally damaged Ia muscle spindle afferents motoneurons. Based on evidence injury acts via immune responses to induce synapse degeneration, we hypothesized...
ABSTRACT The ability to recover purposeful movement soon after debilitating neuromuscular injury is essential animal survival. Various neural and mechanical mechanisms exist preserve whole-limb kinematics despite exhibiting long-term deficits of individual joints following peripheral nerve injury. However, it unclear whether functionally relevant acutely conserved Therefore, the objective this longitudinal study response from four cats was test hypothesis that length localized ankle...