A5027975147- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Receptor Mechanisms and Signaling
- Bacterial biofilms and quorum sensing
- Bacillus and Francisella bacterial research
- Pharmacological Receptor Mechanisms and Effects
- Computational Drug Discovery Methods
- Crystallography and molecular interactions
- Cell death mechanisms and regulation
- Antimicrobial Peptides and Activities
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacogenetics and Drug Metabolism
- Biochemical and Molecular Research
- Synthesis of Organic Compounds
- Click Chemistry and Applications
- Nuclear Receptors and Signaling
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Neuropeptides and Animal Physiology
- Microbial Natural Products and Biosynthesis
- Venomous Animal Envenomation and Studies
- Genetics and Neurodevelopmental Disorders
- Antimicrobial Resistance in Staphylococcus
University of Pavia
2018-2020
University of Groningen
2015
Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that not only odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, this protocol is expected to replace many old procedures in future IMCR other areas as well.
Isocyanide-based multicomponent reactions (IMCR) are among the most important chemical to efficiently generate molecular diversity and have found widespread use in industry academia. Generally, isocyanides synthesized 1–2 steps starting from primary amines. Here, we provide experimental detail on an alternative approach toward formamides and, thus, via Leuckart–Wallach reaction improved variation. The resulting >50 characterized useful materials for IMCR, as well other chemistries. advantage...
The exploration of innovative chemical space is a critical step in the early phases drug discovery. Bis-spirocyclic frameworks occur natural products and other biologically relevant metabolites show attractive features, such as molecular compactness, structural complexity, three-dimensional character. A concise approach to synthesis bis-spirocyclic-based compound libraries starting from readily available commercial reagents robust transformations has been developed. number novel...
Antibiotic resistance is posing a continuous threat to global public health and represents huge burden for society as whole. In the past decade, interference with bacterial quorum sensing (QS) (i.e., cell–cell communication) mechanisms has extensively been investigated valid therapeutic approach in pursuit of next generation antimicrobials. (S)-4,5-Dihydroxy-2,3-pentanedione, commonly known (S)-DPD, small signaling molecule that modulates QS both Gram-negative Gram-positive bacteria,...
Forward-synthetic databases are an efficient way to enumerate chemical space. We explored here whether these good sources of novel protein ligands and how many molecules obtainable in which time frame. Based on docking calculations, series were selected gain insights into the ligand structure-activity relationship. To evaluate novelty compounds a challenging way, we chose β2-adrenergic receptor, for large number is already known. Finding dissimilar thus exception rather than rule. Here...
Resistance to antibiotics is an increasingly serious threat global public health and its management translates significant care costs. The validation of new Gram-negative antibacterial targets as sources for potential remains a challenge all the scientists working in this field. interference with bacterial Quorum Sensing (QS) mechanisms represents potentially interesting approach control growth pursue next generation antimicrobials. In context, our research focused on discovery novel...
Effective therapies for multiple sclerosis (MS) are still missing. This neurological disease affects more than 2.5 million people worldwide. To date, biological immunomodulatory drugs effective and safe during short-term treatment, but they suitable only parenteral administration expensive. Accordingly, academic industrial environments focusing their efforts toward the development of new MS drugs. Considering that neurodegeneration is a contributory factor in onset MS, herein we will focus...
Despite the fact that significant advances in treatment of common cancers have been achieved over years, orphan tumors still represent an important unmet medical need. Due to their complex multifactorial origin and limited number cases, such pathologies often very options poor prognosis. In search for new anticancer agents, our group recently identified RC-106, a Sigma receptor modulator endowed with proteasome inhibition activity. This compound showed antiproliferative activity toward...
Abstract Formamides are found to be a general substitute for the toxic and bad smelling isocyanides in Passerini‐ Ugi‐type multicomponent reactions.