A5102944839- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Infectious Diseases and Tuberculosis
- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Muscle Physiology and Disorders
- Studies on Chitinases and Chitosanases
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Family Caregiving in Mental Illness
- Trigeminal Neuralgia and Treatments
- Family and Disability Support Research
- Macrophage Migration Inhibitory Factor
- Ophthalmology and Eye Disorders
SUNY Upstate Medical University
2023-2025
National Institute of Mental Health and Neurosciences
2019-2020
National Institute of Mental Health
2020
Neurotropism and infiltration by Mycobacterium leprae of peripheral nerves causing neuropathy are well established, but reports central nervous system (CNS) damage exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities the brain spinal cord as lesions in nerve roots plexus leprosy patients. Eight patients aged between 17 41 years underwent detailed clinical, histopathological, MRI evaluation. All had prominent sensory–motor deficits with hypopigmented hypo/anesthetic skin...
Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model.
Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within folP1, rpoB, gyrA gene regions of Mycobacterium leprae genome predominantly neural form DNA samples from 77 nerve tissue were polymerase chain reaction (PCR)-amplified M sequenced drug resistance-determining genes gyrA. The mean age at presentation onset was 38.2 ± 13.4 (range 14-71) years 34.9 12.6...
Motor neuron disease (MND) is a progressive neurodegenerative disease. Ideal management plan in MND includes palliative care initiated from the time of diagnosis. At present, most conditions are cared for at home. Neuropalliative an emerging concept India and social workers integral team members this process. The primary aims study were to explore (a) caregivers' experiences end-of-life stage, (b) sources support individuals their caregivers with stage. In-depth interviews conducted seven...
Identification of Mycobacterium leprae DNA by polymerase chain reaction (PCR) is a reliable and an affordable method to confirm leprosy. from 87 nerve samples (61 paraffin blocks 26 fresh samples) was extracted. amplified PCR 80/87 (92%) specimens. Patients were seen over period 11 years (2007-2019), leprosy diagnosed based on clinical characteristic histopathology findings. The diagnostic possibilities as follows: leprous neuropathy in 73/80 (91.3%), mononeuritis multiplex unknown etiology...
Abstract Background: Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model. Methods: CHIT-1 (n=158), non-ALS (n=12) normal (n=48) subjects were measured...
<h3>Objective:</h3> To report a case of Lyme disease presenting with subacute multiple cranial neuropathies and orbital myositis. <h3>Background:</h3> can present neuropathies. Orbital myositis is not well described as one the rare complications disease. Here, we describe patient an initial manifestation <h3>Design/Methods:</h3> A 69-year-old male history hyperthyroidism status post thyroidectomy, presented new onset headache, double vision, numbness face, dysphagia. On examination, he had...
Abstract Background Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model. Methods CHIT-1 (n=158), non-ALS (n=12) normal (n=48) subjects were measured...