A5076745403- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Tumors and Oncological Cases
- MRI in cancer diagnosis
- Cervical and Thoracic Myelopathy
- Leprosy Research and Treatment
- Autoimmune Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Salivary Gland Tumors Diagnosis and Treatment
- Neurological Complications and Syndromes
- Cerebrospinal fluid and hydrocephalus
- Management of metastatic bone disease
- Neurosurgical Procedures and Complications
- Neurological and metabolic disorders
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Burkholderia infections and melioidosis
- Parasitic infections in humans and animals
- Infectious Encephalopathies and Encephalitis
- Ophthalmology and Eye Disorders
- Bone Tumor Diagnosis and Treatments
Homi Bhabha National Institute
2021-2025
Tata Memorial Hospital
2020-2025
Advanced Centre for Treatment, Research and Education in Cancer
2020-2024
Institute of Neurosciences Kolkata
2020-2021
National Institute of Mental Health and Neurosciences
2017-2021
Fortis Hospital
2020
University of Michigan
2020
Michigan United
2020
Institute of Post Graduate Medical Education and Research
2015
Medical College and Hospital, Kolkata
2015
Grading of gliomas is a piece critical information related to prognosis and survival. Classifying glioma grade by semantic radiological features subjective, requires multiple MRI sequences, quite complex clinically demanding, can very often result in erroneous diagnosis. We used radiomics approach with machine learning classifiers determine the gliomas. Eighty-three patients histopathologically proven underwent brain. Whenever available, immunohistochemistry was additionally augment...
Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation-induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess efficacy oral CHL for treatment brain radionecrosis patients with diffuse glioma. is a phase 2 trial prospective, interventional study. Adults (> 18 years) histological diagnosis glioma developing will be eligible Radionecrosis identified using standard imaging protocols magnetic resonance...
Neurotropism and infiltration by Mycobacterium leprae of peripheral nerves causing neuropathy are well established, but reports central nervous system (CNS) damage exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities the brain spinal cord as lesions in nerve roots plexus leprosy patients. Eight patients aged between 17 41 years underwent detailed clinical, histopathological, MRI evaluation. All had prominent sensory–motor deficits with hypopigmented hypo/anesthetic skin...
Abstract BACKGROUND Pediatric Low-Grade Gliomas (PLGG), encompass a heterogenous set of tumours, with upregulation RAS/MAPK pathway, making them amenable to therapeutic targeting. MEK inhibitors are emerging as promising alternative conventional chemotherapy strategies which have modest efficacy significant toxicity/hospitalisation and hence long periods stay away from home (& school). Recently, we transitioned use inhibitors, where feasible, in children PLGG. METHODOLOGY Retrospective...
We have created the immunodeficient SRG rat, a Sprague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T and circulating NK cells. This model has been tested validated for use in oncology (SRG OncoRat®). The rat demonstrates efficient tumor take rates growth kinetics with different human cancer cell lines PDXs. Although multiple rodent strains are available, some important exhibit poor high variability those models. VCaP prostate is one such line engrafts unreliably grows...
Abstract Constitutional mismatch repair deficiency (CMMRD) is a rare childhood cancer predisposition syndrome that results from biallelic germline mutations in one of the four MMR genes, MLH1, MSH2, MSH6, or PMS2. This characterized by broad spectrum early-onset malignancies, including hematologic colorectal brain tumors, and other malignancies. It common to have more than malignancy an individual diagnosed with CMMRD. In addition primary immunodeficiency form low absent immunoglobulin...
Purpose: Refractory and/or recurrent meningiomas have poor outcomes, and the treatment options are limited. Peptide receptor radionuclide therapy (PRRT) has been used in this setting with promising results. We documented our experience of using intravenous (IV) intra-arterial (IA) approaches Lu-177 DOTATATE PRRT. Methods: Eight patients relapsed/refractory high-grade meningioma received PRRT by IV an IA route. At least 2 cycles were administered. Time to progression was calculated from first...
The clinico-radiological dilemma in post-treatment high-grade gliomas, between disease recurrence (TR) and treatment-related changes (TRC), still persists. FET (Fluoro-ethyl-tyrosine) PET has been extensively used as problem-solving modality for cases where MR imaging is inconclusive. We incorporated a systematic clinical follow-up algorithm multi-disciplinary clinic (MDC) setting to analyse our cohort of gliomas.
Objective: The objective of this study was to retrospectively review clinical data, management protocols, and outcomes patients with fibromatoses head neck region treated at our tertiary care center. Methods: We reviewed the medical records 11 confirmed histopathological diagnosis fibromatosis registered in Department Head Neck Surgery Tata Memorial Centre, India, between 2009 2019. Various pathological features treatment modalities were evaluated. Results: Age ranged 18 74 years, a median...
Diffuse spinal arachnoiditis in neurobrucellosis is a rare manifestation. We report boy aged 17, presenting with hearing impairment and recurrent vomiting for 18 months, weight loss 12 dysphagia, dysarthria, hypophonia 6 gait unsteadiness 5 months. He had bilateral 5th (motor) to 12th cranial nerve palsy, wasting weakness of limbs, fasciculations, absent tendon reflexes, positive Babinski's sign. Cerebrospinal fluid (CSF) showed raised protein pleocytosis. Magnetic resonance imaging (MRI)...
Dentate nucleus is affected in a wide variety of conditions. Magnetic resonance imaging the brain diagnostic modality choice for delineating signal characteristics, which helps narrowing down vast list differentials conditions affecting dentate. Computed tomography plays an important role, especially pathologies associated with calcification dentate nucleus.
Abstract BACKGROUND In patients with medulloblastoma, imaging magnetic resonance (MRI) of the brain and spine plays an integral role in surveillance following treatment completion. The primary objective is to detect early recurrences, possibly leading better salvage treatment. However, there a lack data demonstrate utility possible demerits associated increased resource utilization, scan-related anxiety, lead or length time bias. METHODS Patients histopathological confirmation...
Abstract BACKGROUND Medulloblastomas can recur in up to one-third of the patients despite optimal therapy. The knowledge molecular group provide clues possible pattern relapse and course disease, with therapeutic implications. In present study, we have identified anatomical locations radiological patterns relapse. METHODS AND MATERIALS Patients a histopathological diagnosis available subgroups medulloblastoma first relapse, treated single tertiary care center during 2005-2021 magnetic...
Abstract BACKGROUND Established strategies for infants and young children(IYC) with embryonal tumours of the central nervous system(CNSET) - autologous stem-cell rescue(ASCT) intraventricular chemotherapy(IVCT) – are not universally available. We report outcomes IYC CNSET treated using strategy surgery, pre-irradiation chemotherapy delayed radiation. METHODS Children <3years diagnosed CNSET- medulloblastoma(MB), atypical teratoid/rhabdoid tumour(ATRT), tumour multilayered...
<title>Abstract</title> Introduction: Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation-induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess efficacy oral CHL for treatment brain radionecrosis patients with diffuse glioma. Methods is a phase 2 trial prospective, interventional study. Adults (> 18 years) histological diagnosis glioma developing will be eligible Radionecrosis identified using...
<title>Abstract</title> <bold>Background:</bold> Seizures are common in patients with brain tumors, impacting daily life and healthcare burden. In contemporary neuro-oncology practice, levetiracetam is the most commonly prescribed antiepileptic drug (AED). Although practice widely variable, usually used for 2-3 years following surgery as prophylaxis. However, incidence of seizures post antitumoral treatment relatively low, duration prophylaxis not well defined. To address this knowledge gap,...
Central nervous system (CNS) neoplasms are a vast and diverse group of tumors in adults with variable prognoses depending on histology increasingly understood molecular features. There has been major paradigm shift the approach towards these ever since implications features have recognized. Gliomas primary CNS adults, glioblastomas significant cause morbidity mortality, especially older patients. Apart from gliomas, meningiomas pituitary other groups. This review aims to elucidate role...