A5076959223- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Leprosy Research and Treatment
- Muscle Physiology and Disorders
- Venous Thromboembolism Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Neurogenetic and Muscular Disorders Research
- Mycobacterium research and diagnosis
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Atrial Fibrillation Management and Outcomes
- Myasthenia Gravis and Thymoma
- Stroke Rehabilitation and Recovery
- Ubiquitin and proteasome pathways
- Family and Disability Support Research
- Intracranial Aneurysms: Treatment and Complications
- RNA Research and Splicing
- Aortic aneurysm repair treatments
- Case Reports on Hematomas
- Ocular Diseases and Behçet’s Syndrome
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- ATP Synthase and ATPases Research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
Narayana Health
2020-2022
Mazumdar Shaw Medical Centre
2021-2022
National Institute of Mental Health and Neurosciences
2019-2021
Bangalore Diabetes Centre
2020
Neurotropism and infiltration by Mycobacterium leprae of peripheral nerves causing neuropathy are well established, but reports central nervous system (CNS) damage exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities the brain spinal cord as lesions in nerve roots plexus leprosy patients. Eight patients aged between 17 41 years underwent detailed clinical, histopathological, MRI evaluation. All had prominent sensory–motor deficits with hypopigmented hypo/anesthetic skin...
Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within folP1, rpoB, gyrA gene regions of Mycobacterium leprae genome predominantly neural form DNA samples from 77 nerve tissue were polymerase chain reaction (PCR)-amplified M sequenced drug resistance-determining genes gyrA. The mean age at presentation onset was 38.2 ± 13.4 (range 14-71) years 34.9 12.6...
Congenital myasthenic syndromes (CMS) are a clinically and genetically heterogeneous group of disorders caused by mutations which lead to impaired neuromuscular transmission. SLC25A1 encodes mitochondrial citrate carrier, associated mainly with the severe neurometabolic disease combined D-2- L-2-hydroxyglutaric aciduria (D/L-2-HGA). We previously reported single family homozygous missense variant in phenotype restricted relatively mild CMS intellectual disability, but date no additional...
To elucidate the spectrum of findings on neuroimaging in leprosy with special reference to magnetic resonance imaging (MRI). We retrospectively reviewed MRI thirty-two patients where dedicated plexus, brain and spine had been performed. Twenty-two positive imaging. Six showed involvement peripheral nerves as thickening formation micro or macroabscesses. The brachial plexus hyperintensity ten patients, associated lumbosacral one patient. Four spinal cord discrete T2 hyperintense lesions...
Motor neuron disease (MND) is a progressive neurodegenerative disease. Ideal management plan in MND includes palliative care initiated from the time of diagnosis. At present, most conditions are cared for at home. Neuropalliative an emerging concept India and social workers integral team members this process. The primary aims study were to explore (a) caregivers' experiences end-of-life stage, (b) sources support individuals their caregivers with stage. In-depth interviews conducted seven...
Carotid artery stenting (CAS) has evolved as a first-line therapeutic option for carotid revascularization in indicated patients stroke prevention, but there is still lack of data on its effect cognitive function (CF), especially among Indian patients. To determine the CAS CF and to study immediate delayed complications patients.This was prospective, observational, single-center study. assessed using Addenbrooke's examination version III (ACE) before 3 months after stenting. The demographic...
Motor neuron disease (MND) is a progressive neuromuscular disorder that can have significant and debilitating impact on the affected patient families. Spouses are primary carers for persons with MND in India, life of person their spouse never same after diagnosis.The objective was to explore lived experience spouses diagnosed MND.A qualitative exploratory study three-point interviews conducted caregivers two who were receiving treatment from national tertiary referral care center...
Identification of Mycobacterium leprae DNA by polymerase chain reaction (PCR) is a reliable and an affordable method to confirm leprosy. from 87 nerve samples (61 paraffin blocks 26 fresh samples) was extracted. amplified PCR 80/87 (92%) specimens. Patients were seen over period 11 years (2007-2019), leprosy diagnosed based on clinical characteristic histopathology findings. The diagnostic possibilities as follows: leprous neuropathy in 73/80 (91.3%), mononeuritis multiplex unknown etiology...
Large vessel occlusion stroke contributes to disability and mortality out of proportion its incidence. Over time it was noted that intravenous thrombolysis alone not sufficient for this type. Slowly, endovascular approach mechanical clot retrieval have come be the biggest advances in field neurology as well modern medicine. Although careful selection patients is needed standardized by landmark trials. At same time, thrombectomy now being studied excluded previous trials seemingly coming...
Evaluate real-world clinical and safety outcomes of Endovascular Therapy (EVT) for large core acute ischemic strokes (AIS) with vessel occlusions (LVO) in an Indian population compare them pooled data from recent randomized controlled trials (RCTs).
The treatment of aneurysms with characteristics such as complex morphology, fusiform, blister-like, wide neck, or large size has been revolutionized the introduction flow diverters. Though diverters have several advantages over coiling, they also certain important disadvantages lack immediate protection against rupture, risk ischemic stroke, need for antiplatelet therapy, and long latency complete effect. Derivo Embolization Device (DED) is a second-generation self-expanding device that...
Intravenous thrombolysis alone has poor recanalization rates in large vessel occlusion strokes. Bridging evolved as a standard treatment approach emergent occlusions. Patients who undergo thrombectomy have higher probability of favorable outcomes irrespective the use prior intravenous thrombolysis. Our aim was to compare bridging with direct ischemic stroke due occlusion.We included patients from our registry, strokes, presenting <4.5 hr onset. approach. Direct done contraindications The...
Recanalization failure rate in mechanical thrombectomy (MT) for large vessel occlusions is up to 30%. Outcome greatly depends on recanalization success and, thus, there an urgent need adopt new strategies improve recanalization.To report the feasibility, safety, and outcome of rescue (stenting and/or angioplasty) cases failed MT acute ischemic stroke (AIS) anterior circulation.It was a retrospective observational study where patients undergoing were divided into two groups. The first group...