A5001680992- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Hematological disorders and diagnostics
- Ocular Diseases and Behçet’s Syndrome
- Chronic Lymphocytic Leukemia Research
- Pharmacological Effects of Natural Compounds
- Psoriasis: Treatment and Pathogenesis
- Bacterial Identification and Susceptibility Testing
- Infections and bacterial resistance
- Fungal Infections and Studies
- Acne and Rosacea Treatments and Effects
- Nail Diseases and Treatments
- Herpesvirus Infections and Treatments
- Infectious Diseases and Mycology
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Immune Cell Function and Interaction
- Enterobacteriaceae and Cronobacter Research
- Legionella and Acanthamoeba research
- Diagnosis and treatment of tuberculosis
TLM Shahdara Hospital
2017-2024
Community Hospital
2022-2023
Creative Commons
2022
Swami Rama Himalayan University
2022
All India Institute of Medical Sciences
2022
Ramakrishna Mission Vidyamandira
2018-2021
National JALMA Institute for Leprosy & Other Mycobacterial Diseases
2012-2018
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae and mainly affects skin, peripheral nerves. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with leprosy. shown control several host immunomodulating properties through VDR gene. deficiency was also linked an increased risk for infections metabolic diseases. Objective In the present study, we investigated association of polymorphism, mRNA expression vitamin levels leprosy its...
Purpose: PCR assay is a highly sensitive, specific and reliable diagnostic tool for the identification of pathogens in many infectious diseases. Genome sequencing Mycobacterium leprae revealed several gene targets that could be used detection DNA from clinical environmental samples. The sensitivity particular isolates has not yet been established. present study was conducted to compare RLEP, rpoT, Sod A 16S rRNA M. slit skin smear (SSS), blood, soil samples leprosy patients their...
Neurotropism and infiltration by Mycobacterium leprae of peripheral nerves causing neuropathy are well established, but reports central nervous system (CNS) damage exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities the brain spinal cord as lesions in nerve roots plexus leprosy patients. Eight patients aged between 17 41 years underwent detailed clinical, histopathological, MRI evaluation. All had prominent sensory–motor deficits with hypopigmented hypo/anesthetic skin...
Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within folP1, rpoB, gyrA gene regions of Mycobacterium leprae genome predominantly neural form DNA samples from 77 nerve tissue were polymerase chain reaction (PCR)-amplified M sequenced drug resistance-determining genes gyrA. The mean age at presentation onset was 38.2 ± 13.4 (range 14-71) years 34.9 12.6...
Drug resistance in leprosy is an emerging concern, leading to treatment failures, recurrences, and potential spread of resistant Mycobacterium leprae the community. In this study, we aimed assess drug prevalence patterns amongst patients at a tertiary care referral hospital India.
Background Leprosy relapse/recurrence is a serious concern particularly in leprosy-endemic nation such as India. It believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. Aim To study drug-resistance patterns cases of leprosy relapse chronic/recurrent (c/r)ENL. Methods This cross-sectional conducted over period 1 year included patients diagnosed having...
Leprosy is a disease with spectral clinical manifestations along two types of reactions, type 1 reaction (T1R) and 2 (T2R). T1R especially occurs because the defensive upgradation cell-mediated immunity (CMI) to M. leprae antigens. main cause disability in leprosy. The role conventional adaptive T cells has been well studied understand T1R. A comprehensive understanding unconventional manifestation inflammation during crucial not studied. In our study, we found significantly higher plasma...
To elucidate the spectrum of findings on neuroimaging in leprosy with special reference to magnetic resonance imaging (MRI). We retrospectively reviewed MRI thirty-two patients where dedicated plexus, brain and spine had been performed. Twenty-two positive imaging. Six showed involvement peripheral nerves as thickening formation micro or macroabscesses. The brachial plexus hyperintensity ten patients, associated lumbosacral one patient. Four spinal cord discrete T2 hyperintense lesions...
Purulia is one of the high-endemic districts for leprosy in West Bengal (the eastern part India). The annual new case detection rate (ANCDR) 6.04/100000 (DGHS 2019-20). Our earlier report provided evidence secondary drug resistance relapse cases leprosy. aim current study was to observe primary patterns dapsone, rifampicin, and ofloxacin amongst patients from Purulia, order better understand emergence these drugs.In present study, slit-skin smear samples were collected 145 newly diagnosed...
Leprosy is caused by Mycobacterium leprae and lepromatosis. Both organisms cannot be cultured in vitro. M. lepromatosis was found to associated mainly with diffuse lepromatous leprosy Lucio's phenomena initially. Later, observed borderline cases (BL), (LL) reactional (T1R ENL). Although many are being reported similar clinical features like Lucio phenomenon India but not isolated from these cases. The aim of this study screen MB patients type 2 reaction for the presence We recruited a total...
Background: In endemic regions of several countries, the prevalence leprosy has not come down to level elimination. On contrary, new cases are being detected in large numbers. Clinically, it is frequently noted that despite completion multibacillary multidrug therapy for 12 months, lesions remain active, especially with high bacteriological indices. Aim: The present study focused on finding out viable number Mycobacterium leprae during 12-month regimen therapy, at six and months intervals...
Resistance to antileprosy drugs is one of the main contributors for persistence leprosy in present era. In absence universal antimicrobial resistance (AMR) surveillance through national program, indications testing remain a important dilemma clinicians. WHO recommendations mainly focus on clinical relapse, which could be picked up late with continued transmission and repeated reactions patient. We report here series eighteen cases who were tested AMR view positive morphological index after...
ABSTRACT. Pure neuritic leprosy (PNL) often remains underdiagnosed due to the lack of simple, reliable diagnostic tools detect Mycobacterium leprae. This study aimed investigate utility multiplex polymerase chain reaction (MPCR) in easily accessible and less invasive biopsy sites, including skin samples nasal swabs (NSs), M. leprae . A total 30 ( N = 30) clinically suspected untreated patients with PNL were recruited. Nasal from innervation territory an “enlarged nerve” collected. DNA was...
The data that support the findings of this study are available from corresponding author upon reasonable request. Figure S1. Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.
Leprosy is a chronic infectious granulomatous disorder caused by Mycobacterium leprae , chiefly affecting skin and peripheral nerves. It the only known bacteria to infect Clinical diagnosis of leprosy made when any three cardinal signs defined World Health Organisation present. However, has varied presentations necessitating laboratory diagnostic methods for as well treatment initiation monitoring. Slit-skin smears histopathology form basic diagnostics maximum utility, while neurological...