India employs the Solanaceae family plant chili, Capsicum annuum L., for its pungency and flavor. It has been used as a spice because of delicious flavor zest, which contribute to minerals, vitamins, other culinary ingredients it contains. The objectives present study were determine growth-promoting activities Serratia marcescens Pseudomonas fluorescens on chili plant. PGPR characteristics, i.e., phosphate solubilizing, IAA, NH3, HCN production, antifungal activity, determined in vitro....

Aminoglycosides, amikacin (AK) and kanamycin (KM) are second line anti-tuberculosis drugs used to treat tuberculosis (TB) resistance them affects the treatment. Membrane membrane associated proteins have an anticipated role in biological processes pathogenesis potential targets for development of new diagnostics/vaccine/therapeutics. In this study we compared AK KM resistant susceptible Mycobacterium isolates by 2DE coupled with MALDI-TOF/TOF-MS bioinformatic tools. Twelve were found...

The forests of the central Himalayan region are characterized by dominance some populous and conspicuous tree species across altitudes that crucial for ecosystem functions services. An understanding such with relation to richness, diversity, structural pattern, distribution is in maintaining stability. Considering this, present study was undertaken on four most common forest types dominated Sal (Shorea robusta), Chir-pine (Pinus roxburghii), Banj-oak (Quercus leucotrichophora), mixed-oak (Q....

Senna is a leguminous and industrial crop that produces high-quality glycosides (sennosides) in its leaves pods, which have substantial therapeutic effects for alleviating constipation worldwide. However, further research on employing Jeevamrutha required. As result, the experiment was carried out at CSIR-CIMAP Hyderabad two consecutive years, years 2020–21 2021–22. The main aim to identify optimum dose of higher growth, yield, quality Senna. study used randomized complete block design...

• Biomass and carbon stocks assessment of subtropical temperate forests. Total tree biomass dominant forest stands varied from 227.23 to 577.16 mg ha- 1 . It was found maximum for shorea robusta minimum mixed oak forest. Contribution above below ground 82% 18% respectively. Carbon stock as compared Forests are the world's largest sink play a vital role in climate change mitigation through sequestration; thus forests is important policy prescription management planning. In view this, present...

Abstract Objective: Epithelial ovarian cancer (EOC), a heterogeneous and aggressive gynaecologic malignancy, remains leading cause of cancer-related death due to the lack reliable, sensitive, specific early diagnostic biomarkers. Methods: This study employed cost-effective, CpG site-specific Amplification Refractory Mutation System PCR (ARMS-PCR) assess methylation frequency six diagnostically potent sites (cg18878992, cg00480298, cg029572270, cg10636246, cg10061138, cg12910797) in 45 EOC...

Tuberculosis (TB) is the most threatening infectious disease globally. Although progress has been made to reduce global incidence of TB, emergence multidrug resistant (MDR) TB threatens undermine these advances. To combat disease, novel intervention strategies effective against drug and sensitive subpopulations M. tuberculosis are urgently required as adducts in present treatment regimen. Using THP-1 cells we have analyzed compared protein expression profile broth-cultured intraphagosomally...

Streptomycin (SM) is a broad spectrum antibiotic and an important component of any anti-tuberculosis therapy regimen. Several mechanisms have been proposed to explain the emergence resistance but still our knowledge inadequate. Proteins form very complex network drugs are countered by their modification/efflux or over expression/modification targets. As proteins manifest most biological processes, these attractive targets for developing drugs, immunodiagnostics therapeutics. The aim present...

Tuberculosis is a major health problem in India, and the emergence of multidrug resistant (MDR) extensively drug (XDR) strains Mycobacterium tuberculosis (Mtb) has further complicated situation. Though several studies characterizing sensitive are available literature, almost all done on unrelated strains. Therefore, objective this study was to compare proteomic data four sequential isolates Mtb from single patient who developed MDR-TB during course anti-tuberculosis therapy (ATT).In study,...

Tuberculosis is caused by Mycobacterium tuberculosis, one of the most successful and deadliest human pathogen. Aminoglycosides resistance leads to emergence extremely drug resistant strains M. tuberculosis. Iron crucial for biological functions cells. assimilation, storage their utilization not only involved in pathogenesis but also strains. We previously reported that iron storing proteins (bacterioferritin ferritin) were found be overexpressed aminoglycosides isolates. In this study we...

In the present study, we evaluated antimicrobial activity of clove oil against a range fungal pathogens including that responsible for urogenital infection. Clove was found to possess strong antifungal opportunistic such as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, etc. The be extremely successful in treatment experimental murine vaginitis model animals. On evaluating various formulations, topical administration liposomized most effective vaginal candidiasis.

Emergence of drug resistant tuberculosis like multi (MDR-TB), extensively drug-resistant (XDR-TB) and totally (TDR-TB) has created a new challenge to fight against these bad bugs Mycobacterium tuberculosis. Repurposing revival the drugs are trends/options combat worsen situations in antibiotics resistance era or situation global emergency. Bactericidal synergistic effect repurposed/revived along with latest bedaquiline delamanid used treatment MDR-TB, XDR-TB, TDR-TB might be choice for...

Emergence of extensively drug resistant tuberculosis (XDR-TB) is the consequence failure second line TB treatment. Aminoglycosides are important anti-TB drugs used to treat multi (MDR-TB). Main known mechanism action aminoglycosides inhibit protein synthesis by inhibiting normal functioning ribosome. Primary target ribosomal RNA and its associated proteins. Various mechanisms have been proposed for resistance but still some unsolved. As proteins involved in most biological processes, these...

Drug resistance in tuberculosis predominantly, mono-resistance, multi drug resistance, extensively and totally have emerged as a major problem the chemotherapy of tuberculosis. Failures first second line anti-tuberculosis drugs treatment leads to emergence resistant M.tuberculosis. Few genes are reported principal targets apart from primary many explanations been proposed for but still some mechanisms unknown. As proteins involved most biological processes, these potentially explored unknown...

Tuberculosis still remains one of the most fatal infectious diseases. Streptomycin (SM) is drug choice, especially for patients with multidrug-resistant tuberculosis or category II patients, because it targets protein synthesis machinery by interacting steps translation. Several mechanisms have been proposed to explain resistance, but our knowledge inadequate. Secretome often plays an important role in pathogenesis and considered attractive reservoir development novel diagnostic markers...