A5017864385- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Biosensors and Analytical Detection
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Appendicitis Diagnosis and Management
- Bacteriophages and microbial interactions
- Craniofacial Disorders and Treatments
- Research on Leishmaniasis Studies
- Cancer therapeutics and mechanisms
- Cleft Lip and Palate Research
- Antibiotic Resistance in Bacteria
- Chromium effects and bioremediation
- Hematological disorders and diagnostics
- Shoulder Injury and Treatment
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Trypanosoma species research and implications
- Shoulder and Clavicle Injuries
- COVID-19 Clinical Research Studies
- Bacterial biofilms and quorum sensing
- Ophthalmology and Visual Health Research
- Cardiac, Anesthesia and Surgical Outcomes
All India Institute of Medical Sciences
2013-2024
Central University of Punjab
2022-2024
University of Central Punjab
2024
Adesh University
2023
Sarojini Naidu Medical College
2008-2022
Narayan Medical College and Hospital
2015-2022
Nepalese Army Institute of Health Services
2020
Jawaharlal Nehru Medical College
2018
National JALMA Institute for Leprosy & Other Mycobacterial Diseases
2008
ABSTRACT The MTBDR plus line probe assay (LPA) and Xpert MTB/RIF have been endorsed by the World Health Organization for rapid diagnosis of drug-resistant tuberculosis. However, there is no clarity regarding superiority one over other. In a double-blinded prospective study, we evaluated efficacy on samples that were first tested LPA under revised national tuberculosis control program India. A total 405 sputum from suspected patients included. Of these, 285 smear-positive subjected to LPA....
Miltefosine unresponsive and relapse cases of visceral leishmaniasis (VL) are increasingly being reported. However, there has been no laboratory confirmed reports miltefosine resistance in VL. Here, we report two VL from India. Two patients with were referred to us suspected The first patient was a native the endemic state Bihar, but residing Delhi, non-endemic area. He treated broad-spectrum antibiotics antipyretics treatment. second Jharkhand eastern India (adjoining Bihar), another for...
Tuberculosis (TB) in children is neglected, mainly due to lack of sensitive diagnostic tools. Recently Xpert MTB/RIF assay has revolutionized the field, but its usefulness pediatric TB not been reported from India and no report available on use long term archived samples.We recruited 130 patients with probable intrathoracic tuberculosis their gastric aspirate (GA) induced sputum (IS) samples 2 consecutive days were collected between January 2009 December 2012. All (n = 520) subjected smear...
Prospectively, 162 pleural fluid samples from patients with probable tuberculous effusion were tested by the Xpert MTB/RIF assay and Bactec MGIT-960 culture system. Of these, 43 (26.5%) positive in culture, 23 (14.2%), assay. The sensitivity specificity of compared 54.8% 100%, respectively.
Diagnosis of abdominal tuberculosis (TB) from ascitic fluid samples using routinely available diagnostic methods is challenging due to its paucibacillary nature. Although performance Xpert MTB/RIF assay has been evaluated extensively on pulmonary samples, extrapulmonary still under evaluation.The objective this study was find out the obtained suspected cases TB. Performance compared with Mycobacterium growth indicator tube-960 (MGIT-960) culture and in-house multiplex polymerase chain...
Tuberculosis is a major health problem in India, and the emergence of multidrug resistant (MDR) extensively drug (XDR) strains Mycobacterium tuberculosis (Mtb) has further complicated situation. Though several studies characterizing sensitive are available literature, almost all done on unrelated strains. Therefore, objective this study was to compare proteomic data four sequential isolates Mtb from single patient who developed MDR-TB during course anti-tuberculosis therapy (ATT).In study,...
: Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents made meeting the rising demand for increased testing incompetent, worldwide. A highly sensitive specific antigen-based rapid diagnostic test (RDT) is need hour. objective this study was to evaluate performance a chromatographic immunoassay-based (index test) compared with clinical reference...
Respiratory tract infections remain the leading cause of morbidity and mortality worldwide. The burden is further increased by polymicrobial infection or viral bacterial co-infection, often exacerbating existing condition. Way back in 1918, high due to secondary pneumonia caused was known, a similar phenomenon observed during recent COVID-19 pandemic which worsens Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) It has been that viruses paved way for subsequent infection; similarly, bacteria...
Stump appendicitis is an uncommon but dangerous appendectomy complication that frequently misdiagnosed as other illnesses. has become more common and frequent in recent years, most likely a result of the growing popularity laparoscopic procedures. Early detection essential for initiating treatment preventing major side effects. We present case 22 year old male who complained pain right lower quadrant with nausea fever, nearly 2 months after appendectomy. Imaging findings revealed stump which...
Abstract Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in patients with smear-negative disease. Several biomarkers have been tried but most shown poor sensitivity or specificity. In present study we aimed to evaluate diagnostic utility five novel antigens identified earlier by us. This is an initial conducted on 250 subjects. The recombinant antigens, named as rSS1 (Rv2145c), rSS2 (Rv0164), rSS3 (Rv1437), rSS4 (Rv1827) rSS5 (Rv2970c), were...
Background Nearly after 6 months of the spread Corona Virus Disease 19, along with world Nepal is still trying to control and prevent general population from acquiring it. With limited resources in manpower, technology evidence it has been a difficult battle. But time more understanding virus new detect are coming up. It major breakthrough diagnostic field as this helps us not only detecting but also mobilize our human resources. This comes where cases increasing at an alarming rate....
Background The aim of this multicentric prospective study in India was to assess the performance QuantiFERON TB-Gold tube (QFT-GIT), Tuberculin Skin Test (TST) and microbiological results as additional tools for diagnosing active tuberculosis (TB) latent infection (LTBI) according Human Immunodeficiency Virus (HIV) status. Methods Individuals with without TB HIV were enrolled between 2006–2008. QFT-GIT TST analyzed per se combination data. Results Among 276 individuals (96 pulmonary 180 no...
HIV infection and sexually transmitted diseases in a referral STD centre south India
The pathogenesis of post-kala-azar dermal leishmaniasis (PKDL) is complex. Only 5 to 10% kala-azar patients develop this complication, and it not known whether due changes in the parasite genome or some host factors. Here, we report whole-genome sequence annotated genes whole PKDL strain.
The aim of this multicentric prospective study in India was to assess the value several microbiological tools that contribute diagnosis tuberculosis (TB) according HIV status.Standard on individual specimens were analyzed.Among 807 patients with active TB, 131 HIV-infected, 316 HIV-uninfected and 360 had HIV-unknown status. Among 980 non-active TB subjects, 559 at low risk 421 high M. (Mtb) exposure. Sensitivity smear microscopy (SM) significantly lower HIV-infected (42.2%) than (75.9%) (p =...
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB) and the disease has remained a major health problem in most of developing countries, particularly after emergence multidrug-resistant TB (MDR-TB). The MDR-TB an intriguing subject very little known about vivo processes which take place during acquisition MDR. This study describes unique case pulmonary (PTB) from four sequential isolates MTB could be isolated while patient was on anti-tubercular treatment. first baseline isolate...
Background The aim of this multi-centric prospective study in India was to assess the accuracy a serological test as an additional tool for diagnosing active tuberculosis (ATB). In particular, assay based on ELISA using phenolic glycolipid (PGL-Tb1) or fusion protein (ESAT-6/CFP10) compared tuberculin skin (TST) and microbiological results according HIV status. Methods Individuals with without ATB infection were enrolled. Serology TST analyzed per se combination data. Results Among 778...