A5024875862- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Oral Health Pathology and Treatment
- Head and Neck Surgical Oncology
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Interpreting and Communication in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Ear and Head Tumors
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Oral health in cancer treatment
- Soft tissue tumor case studies
Homi Bhabha National Institute
2018-2025
Tata Memorial Hospital
2015-2025
P. D. Hinduja Hospital and Medical Research Centre
2023-2024
Bharati Vidyapeeth Deemed University
2010-2024
Bhabha Hospital
2023
Advanced Centre for Treatment, Research and Education in Cancer
2020-2022
Eisai (Germany)
2022
Novartis (China)
2022
American Society of Clinical Oncology
2022
AstraZeneca (France)
2022
The management of patients with advanced non-small-cell lung cancer (NSCLC) is becoming increasingly complex, the identification driver mutations/rearrangements and development availability appropriate targeted therapies. In 2018, a group medical oncologists expertise in treating cancers used data from published literature experience to arrive at practical consensus recommendations for treatment NSCLC use by community oncologists. These were subsequently 2019, plan be updated annually. This...
This article is a beginners' guide for performing Cox regression analysis in SPSS. The provides practical steps toward and interpreting the output of SPSS analysis. Along with it, touches on test to be performed before its interpretation.
This randomized clinical trial examines whether adding chemotherapy with pemetrexed and carboplatin to gefitinib improves survival among patients epidermal growth factor receptor ( EGFR )–variant non–small cell lung cancer.
Background: There are limited data available on the treatment and outcome of epidermal growth factor receptor (EGFR) exon 20-mutated lung cancer patients. Hence, we planned an analysis demographic details, clinical profile survival patients with 20 mutations. We compared our results to EGFR tyrosine kinase inhibitor (TKI)-sensitizing activating EGFR/anaplastic lymphoma (ALK)-negative Methods: This was a retrospective who were treated at center between January 2010 August 2014. reviewed...
Introduction: ROS1 oncogenic fusion, which was first identified by Rikova et al, is reported to be present in 1%-2% of non-small cell lung cancers (NSCLCs) and defined as a distinct molecular sub-group.Crizotinib very effective ROS1-positive patients now Food Drug Administration (FDA) approved for the treatment with advanced NSCLC.We report our experience tertiary cancer care hospital India ROS-1 positive patients. Materials method:The series retrospective analysis 22 from prospectively...
Objective Extra Nodal Extension (ENE) assessment in locally advanced head and neck cancers (LAHNCC) treated with concurrent chemo radiotherapy (CCRT) is challenging hence the American Joint Committee on Cancer (AJCC) N staging. We hypothesized that radiology-based ENE (rENE) may directly impact outcomes LAHNSCC radical CCRT. Materials Methods Open-label, investigator-initiated, randomized controlled trial (RCT) (2012–2018), which included planned for Patients were 1:1 to (66–70 grays) weekly...
ABSTRACT Background: Nivolumab and pembrolizumab are approved treatment options for platinum-refractory head-and-neck squamous cell cancer (HNSCC) based on the demonstration of improved outcomes in clinical trials. However, limited data exist their efficacy real-world setting. Objectives: To determine impact immune checkpoint inhibitors HNSCC associated a Materials Methods: This was retrospective study conducted between August 1, 2016, December 31, 2018 Department Medical Oncology at Tata...
Introduction. Brain metastasis is a poor prognostic marker in lung cancer. However it not known whether amongst patients with EGFR mutation those brain metastases have worse outcome. Methods. We compared the survival outcomes between positive and without metastases. In this retrospective analysis of prospective database all metastatic cancer at our centre July 2009 December 2012, were treated either combination chemotherapy or oral TKI. All received whole radiation. Kaplan Meier method was...
The aim of this study was to investigate the feasibility developing a deep learning (DL) algorithm for classifying brain metastases from non-small cell lung cancer (NSCLC) into epidermal growth factor receptor (
Abstract Thiazolidinedione (TZD) drugs have been shown to improve insulin sensitivity, hyperglycemia, and lipid metabolism in people with type 2 diabetes mellitus. In this study, we explored the alpha‐glucosidase inhibitor action of new N‐substituted 5‐benzylidene‐2,4‐thiazolidinedione derivatives. Various substituted benzothiazoles linked 5‐benzylidene‐2,4‐TZD acetamide linker were synthesized characterized by FTIR, 1 H‐NMR, 13 C‐NMR, mass spectrometry. After in‐silico screening all...
Although CT and MRI are crucial imaging modalities for the preoperative staging surgical planning of head neck tumors, quality reports, as well adequate methodology, equally critical. The content report, proper communication these findings to treating physicians important determinants optimal patient care. Synoptic reporting is a method presenting specified data pieces in predetermined format. When compared random reporting, synoptic gives standardized information less time. It enables more...
Abstract Oral cavity cancers contribute to a majority of in India. Clinical examination alone cannot determine the deeper extent disease; therefore, need for cross-sectional imaging including computed tomography and magnetic resonance becomes indispensable pre-treatment evaluation decide optimal plan management. squamous cell (OSCC) can be treated with surgery alone, whereas deep muscle, neurovascular, osseous, or nodal involvement on suggests advanced disease that requires combination...
Objective To assess the ability of 68 Ga DOTA-NOC PET/computed tomography (CT) to differentiate dural metastases from meningioma. Patients and methods who underwent a PET/CT for differentiating meningiomas were included in study. A visual score was assigned lesions (visual – 1 3) relation uptake liver spleen variation evaluated. SUVmax also noted difference values two pathologies compared statistical significance using nonparametric tests. Final diagnosis decided by histopathological...
To study the pattern of mandibular involvement and its impact on oncologic outcomes in patients with gingivo-buccal complex squamous cell carcinoma (GBC-SCC) propose a staging system based bone (MMC: Marrow canal system) compare performance 8th edition American Joint Committee Cancer (AJCC8).This retrospective observational included treatment-naïve GBC-SCC who underwent preoperative computed tomography (CT) imaging between January 1, 2012, March 31, 2016, at tertiary care cancer center....
Introduction:Limited data exists for non-small cell lung cancer (NSCLC) patients harbouring de novo T790M mutation.Methods: NSCLC patients, with T790M, who registered at our institute between 01/03/2015 and 31/12/2019, were considered retrospective analysis of treatment pattern clinical outcomes, i.e., progression-free survival (PFS) overall (OS).Results: Of 1,542 epidermal growth factor receptor (EGFR)-mutated 40 (2.59%) had T790M.Most male (27, 67.5%) smokers (23, 57.5%).The commonest site...
The speed, accuracy, and increasing affordability of next-generation sequencing (NGS) have revolutionized the advent precision medicine. To date, standardized validation criteria for diagnostic accreditation do not exist due to variability across multitude NGS platforms within processes. In molecular diagnostics, it is necessary ensure that primary material FFPE sample has good quality optimum quantity analysis, otherwise laborious expensive test may result in unreliable information....
Access to cancer care is an issue in low and middle-income countries. The problem worse with respect access new therapies like checkpoint inhibitors. Hence, we decided audit our practice the head neck thoracic medical oncology unit from 2015 2019 study accessibility of inhibitors factors influencing it.All patients who were registered between included study. Patients received immunotherapy identified prospective database maintained by department. We made a list eligible for per year how many...