A5078423889- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Thyroid Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Oral Health Pathology and Treatment
- Oral health in cancer treatment
- Thyroid and Parathyroid Surgery
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Reconstructive Facial Surgery Techniques
- Head and Neck Anomalies
- Lung Cancer Research Studies
- Skin and Cellular Biology Research
- Cleft Lip and Palate Research
- Nerve Injury and Rehabilitation
- Proteoglycans and glycosaminoglycans research
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
Homi Bhabha National Institute
2017-2025
Tata Memorial Hospital
2016-2025
Advanced Centre for Treatment, Research and Education in Cancer
2010-2025
Max Healthcare
2024
Dr. Balabhai Nanavati Hospital
2023-2024
Institut de Virologie
2022
Bhabha Atomic Research Center Hospital
2021
University of Birmingham
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Whether patients with early-stage oral cancers should be treated elective neck dissection at the time of primary surgery or therapeutic after nodal relapse has been a matter debate.In this prospective, randomized, controlled trial, we evaluated effect on survival node (ipsilateral surgery) versus (watchful waiting followed by for relapse) in lateralized stage T1 T2 squamous-cell carcinomas. Primary and secondary end points were overall disease-free survival, respectively.Between 2004 2014,...
There is a lack of published literature on systemic therapeutic options in cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) undergoing chemoradiation. Docetaxel was assessed as radiosensitizer this situation.This randomized phase II/III study. Adult (age ≥ 18 years) LAHNSCC planned for chemoradiation an Eastern Cooperative Oncology Group performance status 0-2 who were randomly assigned 1:1 to either radiation alone or concurrent docetaxel...
Abstract Background The aim of this study is to determine the need for a randomized controlled trial in order define role an elective neck dissection (END) treatment early tongue cancers. Methods We present large retrospective analysis patients with T1‐2 N0 squamous cell cancers oral anterior treated at single institution. A total 359 eligible were divided into 2 groups: END and wait watch (WW). An survival outcomes prognostic factors was conducted. Results estimated 3‐ 5‐year disease‐free...
Background Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes a phase 2 study, authors conducted 3 study confirm these findings. Methods This open‐label, investigator‐initiated, 3, randomized trial was from 2012 2018. Adult who were fit for radical 1:1 receive either radiotherapy (66‐70 grays) concurrent weekly cisplatin (30 mg/m ) (CRT) or same schedule CRT (200 mg) (NCRT).The primary endpoint progression‐free...
Background: Overburdened systems and concerns of adverse outcomes have resulted in deferred cancer surgeries with devastating consequences. In this COVID pandemic, the decision to continue elective surgeries, their subsequent outcomes, are sparsely reported from hotspots. Methods: A prospective database Department Surgical Oncology was analysed March 23rd April 30th, 2020. Findings: Four hundred ninety-four were performed (377 untested 117 tested for Covid 19 before surgery). Median age 48...
The objective of this study was to explore the potential role and safety neoadjuvant chemotherapy (NACT) in tumor shrinkage resultant mandibular preservation oral cancers compared with conventional surgical treatment.This a single-center, randomized, phase II trial treatment-naive histologically confirmed squamous cell carcinoma cavity cT2-T4 N0/N+, M0 (American Joint Committee on Cancer, seventh edition) stage, necessitating resection mandible for paramandibular disease absence...
Carcinoma of the gingivobuccal complex is commonly associated with use smokeless tobacco known as "quid."We conducted a retrospective chart review 511 patients advanced cancer surgically treated during 1994 to 1995. We evaluated patterns disease failure in these and correlated disease-free survival various prognostic factors.During median follow-up 46 months, 159 locoregional recurrences 11 distant metastases were detected 148 patients. Seventy-nine percent appeared within 18 months surgery,...
The present study identifies the prognostic factors influencing oral cancers in a large cohort of patients treated at single institute.This is an audit 1180 from 1990 to 2004 service setting with prospective data collection. Patients were radical radiotherapy or planned for surgery and post operative (PORT). None received postoperative concurrent chemoradiation. For analysis, divided into Group 1 2 based on cavity subsite.Of entire cohort, 810 had tumors Gingivo-alveolo-buccal complex, lip...
Fascin is a globular actin cross-linking protein, which plays major role in forming parallel bundles cell protrusions and found to be associated with tumor invasion metastasis various type of cancers including oral squamous carcinoma (OSCC). Previously, we have demonstrated that fascin regulates polymerization thereby promotes motility K8-depleted OSCC cells. In the present study investigated progression OSCC.To understand development and/or progression, was overexpressed along vector...
The purpose of this study was to report the results a phase III, 3-arm, randomized trial comparing conventional radiotherapy (RT) concurrent chemoradiotherapy (CRT) and accelerated RT in advanced head neck squamous cell carcinoma (HNSCC).One hundred eighty-six 750 planned patients were receive one following treatment plans: (66-70 Gy/2 Gy fraction/5 fractions weekly; CRT weekly cisplatin (30 mg/m(2) ) with same dose; or alone 66 70 fraction/6 available for analysis. primary endpoint...
Abstract We report the patterns of failure and survival with carcinoma unknown primary head neck (CUP-HN). This is a retrospective audit CUP-HN patients treated curative radiotherapy (RT) between January 2006 December 2020. All received RT to neck—definitive (DRT) or surgery (Sx) + adjuvant (ART), ± chemotherapy. Of 108 eligible patients, 81 (75%) used tobacco. Positron emission tomography computed was performed in 102 (94.4%). Seventy-five (69.4%) were DRT chemotherapy, while 33 (30.6%)...
The purpose of this study was to identify the prognostic factors affecting outcome in patients with mucoepidermoid carcinoma (MEC) parotid gland.A total 113 MEC who were treated between 1993 and 2002 analyzed.At median follow-up 49 months (range, 1-143 months), disease-free survival (DFS) at 5 10 years 84.6 84.6%, 80.7% 67.3%, 52.5% 35.0% for low-grade, intermediate-grade, high-grade tumors, respectively. Five-year 10-year overall 96.8% low-grade tumors; 94.1% 82.4%, respectively,...
Abstract Oral cavity squamous cell cancers form a significant percentage of the seen in India. While clinical examination allows direct visualization, it cannot evaluate deep extension disease. Cross-sectional imaging has become cornerstone pretreatment evaluation these and provides accurate information about extent depth disease that can help decide appropriate management strategy indicate prognosis. Early are treated with single modality, either surgery or radiotherapy while advanced...
Summary Hypoxia within the tumor microenvironment (TME) is a key factor contributing to immunosuppression in tumors, co-relating with poor treatment outcome and decreased overall survival advanced oral cancer (OC) patients. Vδ2 dominant subset of gamma delta T cells (γδT cells) present peripheral blood which exhibits potent anti-tumor cytotoxicity evolving as player anti-cancer cellular therapy. However, fate γδT hypoxic tumors remains elusive. In study, we compared effect hypoxia (1% O2)...
Background and Objective The treatment of pediatric thyroid cancer evokes considerable controversy. extent surgery role postoperative radioactive iodine are not clearly defined. We analyzed the behavior cancers its management. Methods Eighty-three patients, from 1964–2000, were identified by a search our database. clinical course 26 patients was evaluated because inadequate follow-up remaining 57 included in final survival analysis. These for analyses epidemiological data. Results There 27...
The purpose of this study was to compare sentinel node biopsy (SNB) and ultrasound-guided fine-needle aspiration cytology (FNAC) for preoperative evaluation the N0 neck in T1 T2 oral cavity squamous cell carcinoma (SCC).Fifty-one consecutive patients with SCC were included study. Preoperative ultrasound performed all patients. Ultrasound-guided FNAC whom result reported as indeterminate or positive. SNB done followed by elective dissection (END). Histopathology END considered gold standard...
Vimentin is an intermediate filament protein, predominantly expressed in cells of mesenchymal origin, although its aberrant expression seen many carcinomas during epithelial transition. In cancer, vimentin associated with the transition from a more differentiated phenotype to dedifferentiated state. view perceived role keratins (Ks) as regulators differentiation epithelia, it was important understand whether modulates through reprogramming keratins, transformed cells. To address this, stably...
To study multistep tumorigenesis process, there is a need of in-vitro 3D model simulating in-vivo tissue. Present aimed to reconstitute tissue models comprising various stages neoplastic progression tongue and evaluate the utility these investigate role stromal fibroblasts in maintenance desmosomal anchoring junctions using transmission electron microscopy. We reconstituted representing normal, dysplastic, malignant tissues by seeding primary keratinocytes on either fibroblast embedded...