A5107480455- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Biosimilars and Bioanalytical Methods
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- PARP inhibition in cancer therapy
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Sinusitis and nasal conditions
- Maternal and fetal healthcare
- Economic and Financial Impacts of Cancer
- Occupational and environmental lung diseases
- Genetics, Bioinformatics, and Biomedical Research
- Palliative Care and End-of-Life Issues
- Parvovirus B19 Infection Studies
- Ion channel regulation and function
- Head and Neck Surgical Oncology
- Gestational Trophoblastic Disease Studies
Tata Memorial Hospital
2017-2024
Homi Bhabha National Institute
2018-2024
Apollo Hospitals
2022
Safdarjang Hospital
2020
Vardhman Mahavir Medical College & Safdarjung Hospital
2016
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2015
Post Graduate Institute of Medical Education and Research
2015
Background Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes a phase 2 study, authors conducted 3 study confirm these findings. Methods This open‐label, investigator‐initiated, 3, randomized trial was from 2012 2018. Adult who were fit for radical 1:1 receive either radiotherapy (66‐70 grays) concurrent weekly cisplatin (30 mg/m ) (CRT) or same schedule CRT (200 mg) (NCRT).The primary endpoint progression‐free...
Abstract Background Checkpoint inhibitors (Nivolumab and Pembrolizumab) are approved for multiple indications in solid tumors. However access to these therapies is limited low middle income countries. Hence we performed an audit identify accessibility, adverse event rates, compliance, progression free survival overall Methods This was a single center retrospective analysis of prospective data base patients with non‐melanoma tumors who were treated immunotherapy from August 2015 November...
347 Background: Immune checkpoint inhibitors, predominantly pembrolizumab and dostarlimab, have been approved in deficient mismatch repair (dMMR)/ microsatellite instability (MSI) non-colorectal cancers. There is also an emerging data to suggest significant clinical activity for low-dose ICIs (LD-ICIs) these Methods: A multi-institutional retrospective analysis Indian patients with dMMR/MSI-H advanced/metastatic carcinomas treated (irrespective of dose or schedule) between 2017 2024 was...
This study reports the incidence of distress, factors associated with and a practical strategy to resolve distress in patients head neck cancer who are starting palliative chemotherapy.Adult planned for chemotherapy underwent screening before start treatment as part this single-arm prospective study. Patients had score > 3 on National Comprehensive Cancer Network (NCCN) thermometer were counseled initially by clinician. Those continued have high after clinician-led counseling referred...
Introduction: Checkpoint inhibitors (CPIs) are rapidly becoming the standard of care in solid tumors for multiple indications. Steroids due to their immunosuppressive nature might decrease efficacy these agents. To test this hypothesis, we performed an audit our patients who had received CPI and concomitant steroids. Patients Methods: This was a retrospective prospectively maintained database at Tata Memorial Hospital, Mumbai, between August 2015 November 2018. palliative indication were...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the most common malignancy group in India several other low- middle-income countries. Currently, majority of patients present advanced stage where systemic therapy standard care. Multiple relapses are also not uncommon. Almost all HNSCC tumors have epidermal growth factor receptor (EGFR) overexpression, making an attractive target. Cetuximab successful method to target EGFR HNSCC. After decades its use, it still a prominent part...
Introduction: Cytomegalovirus (CMV) infection is very common, although its manifestation as disease occurs usually in the setting of immunosuppression. It seen hematological malignancies and post-transplant recipient patients. Data about CMV reactivation solid are limited.Materials Methods: This was a retrospective analysis adult patients (from past 10 years clinical records) with various malignancies, who had deoxyribonucleic acid (DNA) positivity varied presentation.Results: Of total 73...
© 2020. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as original work given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Background: Hypothyroidism is a known side effect of head-and-neck cancer treatment and might improve outcomes. However, whether the development hypothyroidism or maintaining hypothyroid state remains factor unclear. Methods: Once-a-week versus once-every-3-weeks cisplatin chemoradiation in locally advanced head neck was Phase III open-label, noninferiority randomized study conducted by our group Medical Oncology Department Tata Memorial Hospital, Mumbai, India. The database this assessed...
Objectives: PacliALL TM is the first and only indigenously developed brand of nab-paclitaxel in India that has shown bioequivalence to global reference (Abraxane ® ). However, real-world Evidence scarce about use it different tumor sites beyond approved indications. This study assessed effects (PacliALL ) on clinical outcomes patients diagnosed with metastatic cancers a tertiary care hospital India. Material Methods: In this retrospective study, data demographics, medical history, laboratory...
Abstract Immunotherapy has improved outcomes in many advanced solid tumors. In resource-constrained settings, less than 2% of patients can afford standard dose immunotherapy. A recent phase II study showed the efficacy low-dose immunotherapy this setting. We used on a compassionate basis who had progressed available treatment options and was not feasible. retrospectively collected data from medical oncology department for consecutive initially received lines therapy followed by (nivolumab 40...
© 2020. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as original work given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
© 2019. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as original work given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Objectives: Molecular oncology (GO) is a discipline that focuses on the diagnosis, staging, prognosis, and management of cancer with help molecular genetics. Increasing understanding changes drive tumor progression has transformed treatment this disease. The main goal study was to describe current situation in India regarding knowledge, attitude, practice through an online survey oncologists. Material Methods: A descriptive sent several hospitals by means E-mails social media. Results:...
A 21-year-old normotensive male patient presented with acute-onset flaccid paralysis the history of a similar episode few months back. Clinical and laboratory evaluation revealed lower motor neuron type quadriparesis hypokalaemia, normal anion gap metabolic acidosis, bicarbonaturia transtubular potassium concentration gradient more than 7. Subsequently, urine acidification test (by ammonium chloride challenge test) was performed diagnosis renal tubular acidosis established. The ultrasound...
e18862 Background: There are limited data available from India on the real-world use of checkpoint inhibitors. Hence we did this analysis across to study pattern and outcomes with Methods: This was a retrospective multicentric protocol. Patients who received immunotherapy January 2016 October 2021 were included. The baseline demographic, previous treatment, response, date progression, death status noted. SPSS version 20 used for analysis. Descriptive statistics performed. Kaplan Meier method...
Multiple primary lung cancer may present in synchronous or metachronous form. Synchronous multiple is defined as lesions that develop at the same time, whereas describes different times, typically following treatment of cancer. Patients with previously treated are risk for developing cancer; but, success computed tomography (CT) and positron emission (PET), ability to detect both has increased. malignancies divided according Moertel's [1] definition into metachronous: (1) refers tumors...