A5024070304- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- CNS Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- SARS-CoV-2 and COVID-19 Research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Moyamoya disease diagnosis and treatment
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Neurofibromatosis and Schwannoma Cases
Amrita Institute of Medical Sciences and Research Centre
2024-2025
Institute of Medical Sciences
2024
All India Institute of Medical Sciences Bhopal
2012-2023
All India Institute of Medical Sciences
2012-2023
All India Institute of Medical Sciences Raipur
2012-2023
BLK Super Speciality Hospital
2019-2022
Max Healthcare
2022
Dr. B.L. Kapur Memorial Hospital
2021
Max Super Speciality Hospital
2021
Institute of Liver and Biliary Sciences
2016-2019
6004 Background: CCRT using 3 weekly cisplatin (DDP) 100mg/m 2 is considered standard nonsurgical option for LAHNSCC. Many prefer DDP 40 mg/m assuming this to be non inferior, with better radio sensitization, and less toxic but without robust supporting evidence. We designed inferiority trial compare DDP. Methods: Multicentric RCT 100 (Control as C) x times (Test T) x7 concurrent RT definitive therapy in nasopharyngeal Primary objective was years loco regional control (LRC) rates. Secondary...
347 Background: Immune checkpoint inhibitors, predominantly pembrolizumab and dostarlimab, have been approved in deficient mismatch repair (dMMR)/ microsatellite instability (MSI) non-colorectal cancers. There is also an emerging data to suggest significant clinical activity for low-dose ICIs (LD-ICIs) these Methods: A multi-institutional retrospective analysis Indian patients with dMMR/MSI-H advanced/metastatic carcinomas treated (irrespective of dose or schedule) between 2017 2024 was...
Poly (ADP-ribose) polymerase inhibitors (PARPi) have proven efficacy in treatment of BReast CAncer (BRCA) gene mutation-positive platinum-sensitive ovarian cancers. There is paucity data for their role platinum-resistant cancer (PROC). We report here retrospective analysis outcome PARPi a group patients including those PROC.We analyzed all consecutive who received PARPi. The monotherapy was assessed with relapsed high-grade serous carcinoma gBRCAm. drug procured through compassionate...
The aim of this study was to evaluate the outcomes following upfront pancreaticoduodenectomy (PD) in severely jaundiced (serum bilirubin level ≥15 mg/dl) patients with malignant distal common bile duct (CBD) obstruction.Recent studies have failed show benefits preoperative biliary drainage (PBD) before PD. In addition, there is limited data on impact PD perioperative patients.We reviewed prospectively collected 177 who had undergone for CBD obstruction from May 2009 2018. Study subjects were...
PURPOSE The information about the outcome of primary CNS lymphoma (PCNSL) in India is scarce, because there no population-based or large hospital-based data. MATERIALS AND METHODS This a retrospective study that spanned 17 years (2001 to 2017) PCNSL at All Institute Medical Sciences (AIIMS), which tertiary care center Northern India. RESULTS Only one 99 patients was positive for HIV serology. Diffuse B-cell most common histology (97.7%). median patient age 50 (range, 13 70 years), and ratio...
Abstract The combination of cyclin dependent kinase 4/6 inhibitors with endocrine therapy is the standard in hormone receptor positive HER-2 negative metastatic breast cancer (HR+/HER2− MBC). Several randomized trials have shown benefits this combination, however, real world evidence Indian patients warranted. present study reports largest multicentric data from population on use Palbociclib HR+/HER2− MBC. A MBC who received palbociclib hormonal agent (Aromatase inhibitors/Fulvestrant)...
Plasma cell dyscrasias account for 1% of all malignancies and 10% hematological malignancies. About 5% patients with a plasma dyscrasia present either solitary bone plasmacytoma (SBP) or, less commonly, soft tissue mass, extramedullary (EMP) monoclonal cells. In this study we the clinical features, management outcome 60 plasmacytoma, who constituted 5.6% 1129 treated over 10-year period at All India Institute Medical Sciences. Median age was 49 years. Fifty-two had SBP eight EMP. Forty-nine...
Background: The optimal sequence and extent of multimodality therapy remains to be defined for extrapulmonary small cell carcinoma because its rarity. purpose our study was assess the response neoadjuvant chemotherapy followed by chemoradiation/radiation in patients with carcinoma. Materials Methods: Four consecutively diagnosed were included this study. primary tumor site oropharynx three esophagus one. limited disease treated concurrent chemoradiation (n=2) or radiotherapy (n=1). patient...
We present a case report of broncho-biliary fistula that developed due to the blockage biliary stent placed during management pancreatic neuroendocrine tumor (pNET); diagnosed on high clinical suspicion, percutaneous cholangiogram and contrast enhanced computed tomography (CECT); successfully treated with transhepatic drainage (PTBD).
Abstract The real‐world data on short course of immune checkpoint inhibitor (ICI) use are sparse and merit exploration. A multicentric observational study the safety efficacy ICI in oncology patients between August 2014 October 2020 involves 1011 across 13 centers India. median age was 59 (min 16‐max 98) years with male preponderance (77.9%). predominant cohort received short‐course therapy; number cycles 5 (95% confidence interval [CI] 1‐27), duration therapy 3 CI 0.5‐13) months. ICIs were...
Abstract Hand-foot syndrome, is a side effect of cytotoxic chemotherapy, causes erythema, dysthesias, swelling palms and soles sometimes blisters. Rarely, it may ulcerate. The most commonly used drug that frequently this reaction 5-fluorouracil or its prodrug oral capecitabine. High dose cytarabine known to cause HFS. Here we report case HFS caused by standard cytarabine.
An Unusual CaseCarcinoma Gall Bladder (CaGB) is the most common biliary tract malignancy with geographic and ethnic disparities.It one of malignancies in north India, particularly females.It has a vague presentation mostly detected advanced stage.We here report an interesting case which initially presented as liver abscess latter diagnosed gall bladder cancer cardiac metastasis.
We are describing a case of plasmodium vivax malaria in child with complications including pancytopenia secondary to marrow involvement, jaundice and neurological features. The improved antimalarial treatment.DOI: 10.3126/jnps.v30i3.3922J Nep Paedtr Soc 2010;30(3):168-170
Abstract Introduction There is limited literature available regarding the prevalence and durability of immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) in cancer patients. Objective The aim this study was analyze seroconversion rate patients recovered from SARS-CoV-2 infection. Materials Methods We retrospectively analyzed antibody levels rates serum samples 135 who had Chemiluminescent immunoassay using Roche...