A5026835244- Synthesis and Reactivity of Heterocycles
- Electrochemical sensors and biosensors
- Synthesis and Biological Evaluation
- Advanced Chemical Sensor Technologies
- Cancer therapeutics and mechanisms
- Medicinal Plants and Neuroprotection
- Tuberculosis Research and Epidemiology
- Aluminum Alloy Microstructure Properties
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical Analysis and Applications
- Electronic Packaging and Soldering Technologies
- COVID-19 and healthcare impacts
- Click Chemistry and Applications
- Gestational Trophoblastic Disease Studies
- Cancer Genomics and Diagnostics
- Surface and Thin Film Phenomena
- Cancer Cells and Metastasis
- Metal Forming Simulation Techniques
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Synthesis and Characterization of Pyrroles
- Synthesis and bioactivity of alkaloids
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- Genital Health and Disease
National Institute of Pharmaceutical Education and Research
2023-2025
Artemis Hospitals
2022-2025
Indian Institute of Technology Bombay
2024
Guru Ghasidas Vishwavidyalaya
2022-2023
Bharati Vidyapeeth Deemed University
2023
P. D. Hinduja Hospital and Medical Research Centre
2022
National Hospital
2022
347 Background: Immune checkpoint inhibitors, predominantly pembrolizumab and dostarlimab, have been approved in deficient mismatch repair (dMMR)/ microsatellite instability (MSI) non-colorectal cancers. There is also an emerging data to suggest significant clinical activity for low-dose ICIs (LD-ICIs) these Methods: A multi-institutional retrospective analysis Indian patients with dMMR/MSI-H advanced/metastatic carcinomas treated (irrespective of dose or schedule) between 2017 2024 was...
Abstract A thorough search for the development of innovative drugs to treat tuberculosis, especially considering urgent need address developing drug resistance, we report here a synthetic series ethyl 3‐benzoyl‐7‐morpholinoindolizine‐1‐carboxylate analogues ( 5a‐o ) as potent anti‐tubercular agents. These morpholino‐indolizines were synthesized by reacting 4‐morpholino pyridinium salts, with various electron‐deficient acetylenes afford ). All intermediate and final compounds are...
Abstract A facile and atom‐efficient route via a new aqueous synthetic protocol for the greener more efficient preparation of 3‐phenylpyrrolo[1,2‐ ]pyrazine 3‐phenylpyrazino[1,2‐ ]indole by one‐pot, three‐component method under mild reaction conditions is developed with substituted phenacyl bromides, ammonium hydroxide, corresponding 1 H ‐pyrrole‐2‐carbaldehyde ‐indole‐2‐carbaldehyde. cascade consisting N‐alkylation, imine formation, annulation condensation produces sequence three C−N bonds.
High mortality has been observed in the cancer population affected with COVID-19 during this pandemic. We undertook study to determine characteristics and outcomes of patients assessed factors predicting outcome.Patients all age groups a proven history malignancy recent diagnosis SARS-CoV-2 infection based on nasal/nasopharyngeal reverse transcriptase (RT)-PCR tests were included. Demographic, clinical laboratory variables compared between survivors non-survivors groups, respect...
e12517 Background: Breast malignancies is a leading cause of cancer-related mortalities and show ascending incidence rate. Despite advancements in our understanding the disease, its clinical outcome often dismal. This largely remains owing to characteristic wide window relapse, spanning months decades after primary treatment. Therefore, continuous monitoring disease an offered choice detect metastatic progression recurrence. Circulating tumor cells (CTCs) have emerged as powerful prognostic...
e23520 Background: The utility of comprehensive genome profiling is not well validated in early-stage sarcoma. 5-year survival rate for metastatic sarcoma less than 20%. application Next Generation Sequencing (NGS) on tumor DNA has led to the identification a multitude actionable alterations oncogenes & suppressor genes alongside detection immunotherapy markers like microsatellite instability, mutational burden, and homologous recombinant deficiency. Methods: We retrospectively analyzed...