A5063828283- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Renal Transplantation Outcomes and Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- COVID-19 and healthcare impacts
- Hematological disorders and diagnostics
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Histone Deacetylase Inhibitors Research
- Antifungal resistance and susceptibility
- Retinoids in leukemia and cellular processes
- Organ and Tissue Transplantation Research
Homi Bhabha National Institute
2018-2025
Tata Memorial Hospital
2016-2025
Advanced Centre for Treatment, Research and Education in Cancer
2016-2025
Institute of Hematology & Blood Diseases Hospital
2023
Dana-Farber Cancer Institute
2023
Indira Gandhi Centre for Atomic Research
2020
All India Institute of Medical Sciences
2003
There are sparse longitudinal data on SARS-CoV-2 infection after previous and partial or full vaccination.This study of a cohort healthcare workers used Kaplan-Meier analysis with appropriate definition events censoring Cox models to assess outcomes, cut-off June 18, 2021.A total 1806 individuals median age 32 (18-64) years, 1483 (82.1%) at least one vaccine dose, 1085 (60.1%) 2 doses, 408 (22.6%) episode infection, 6 (1.47%) episodes were included in the analysis. At follow-up 38.4 weeks...
A young boy developed steroid refractory GVHD post haploidentical transplant for relapsed B-ALL. He was on systemic immunosuppression with two immunosuppressants, and had history of CMV reactivation tuberculosis. Eight months post-transplant, he hospitalized multi-drug-resistant gram-negative sepsis, during the same episode, penile lesions which progressed to dry gangrene glans-penis. Fusarium grew in blood lesions. On retrospective thinking, it discerned that his onychomycoses were probable...
Graft rejection is an important concern following haploidentical transplant with a reported incidence of 10-15%. The number human leukocyte antigen (HLA) mismatches and the vector mismatch have not been found to be associated risk graft in transplants. Patients HLA homozygosity at all loci (HLA-A, B, C, DRB1, DQB1) undergoing rare scenario that results zero graft-versus-host (GvH) direction 2-5 host-versus-graft (HvG) depending on donor haplotype. This heavily skewed unopposed...
Abstract Background There is limited data on outcomes in cancer patients with coronavirus disease 2019 (COVID‐19) from lower middle‐income countries (LMICs). Patients and Methods This was an observational study, conducted between 12 April 10 June 2020 at Tata Memorial centre, Mumbai, undergoing systemic therapy laboratory confirmed COVID‐19. The objectives were to evaluate cumulative 30‐day all‐cause mortality, COVID‐19 attributable factors predicting time viral negativity after initial...
The goal of HAART is to achieve maximal and durable suppression virus replication. Adherence plays a very important role in success antiretroviral therapy.To find out the rate adherence factors that influence therapy (ART).The present study was conducted Department Medicine tertiary care hospital from November 2007 September 2009. Patients attending ART centre OPD started on for at least 6 months were included study. A pretested proforma MMAS questionnaire every patient used data collection....
Central venous catheters (CVCs) represent a significant source of infection in patients undergoing hematopoietic stem cell transplantation and can add to the cost care, morbidity, mortality. Organisms forming biofilms on inner surface require much higher local antibiotic concentration clear pathogen growth. Antibiotic lock therapy (ALT) represents one such strategy achieve high intraluminal concentrations antibiotics facilitate catheter salvage. Patients with colonization (CC) or...
Abstract The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results superior survival compared with the protocols. Pediatrics-inspired carry an increased risk toxicity treatment-related mortality low resource settings, which can offset potential benefits. We studied outcomes prognostic factors treatment AYA ALL a regimen. retrieved data regarding demographics, investigations, details, toxicities from electronic medical records...
Background Transplant related toxicity is a major therapeutic challenge. We have previously reported that the of chemotherapy largely not directly because drugs themselves; rather it mainly due to DNA damage, apoptosis and hyper-inflammation triggered by cell-free chromatin particles are released drug-induced host cell death. Cell-free can be inactivated free-radicals which generated when nutraceuticals resveratrol copper administered orally. investigated if combination would reduce...
Introduction. Brain metastasis is a poor prognostic marker in lung cancer. However it not known whether amongst patients with EGFR mutation those brain metastases have worse outcome. Methods. We compared the survival outcomes between positive and without metastases. In this retrospective analysis of prospective database all metastatic cancer at our centre July 2009 December 2012, were treated either combination chemotherapy or oral TKI. All received whole radiation. Kaplan Meier method was...
Detection of measurable residual disease (MRD) by mutation specific techniques has prognostic relevance in NPM1 mutated AML (NPM1mut AML). However, the clinical utility next generation sequencing (NGS) to detect MRD remains unproven. We analysed significance monitoring using ultradeep NGS (NGS-MRD) and flow cytometry (FCM-MRD) 137 samples obtained from 83 patients NPM1mut at end induction (PI) consolidation (PC). could monitor 12 different types mutations a sensitivity 0.001% NGS-MRD....
Highlights•This retrospective study was done to determine the utility of leflunomide in cytomegalovirus (CMV) reactivations after allogenic stem cell transplants. Leflunomide could clear CMV viremia 38% reactivation episodes.•CMV clearance rate best when copy number <2 × 103/mL compared with higher numbers (P= 0.022) and a pre-emptive setting. not beneficial once there end-organ involvement.•Being more effective at low burden, may have role as prophylactic agent haploidentical transplants,...
Introduction: One of the mainstays chemotherapy in acute myeloid leukemia (AML) is induction with a goal to achieve morphological complete remission (CR). However, not all patients by this criterion long-term and subset relapse. This relapse explained presence measurable residual disease (MRD). Methods: We accrued 451 consecutive adult AML (from March 2012 December 2017) after informed consent. All received standard chemotherapy. MRD testing was done at post-induction and, if feasible,...
Panel based next generation sequencing was performed on a discovery cohort of AML with RUNX1-RUNX1T1. Supervised machine learning identified NRAS mutation and absence mutations in ASXL2, RAD21, KIT FLT3 genes as well low to be associated favorable outcome. Based this data patients were classified into poor genetic risk classes. Patients had significantly lower overall survival (OS) relapse free (RFS). We could validate these findings independently validation (n = 61). the group more likely...
PURPOSE The prognosis of relapsed and refractory multiple myeloma (RRMM) that is to bortezomib lenalidomide very poor wherein the median survival between 3 9 months. We did this retrospective analysis study pattern utilization, tolerance, outcomes with pomalidomide in these patients having RRMM. MATERIALS AND METHODS Retrospective all who were treated generic at Tata Memorial Centre, Mumbai, during period May 2017 March 2019 was done. Patients secretory disease had completed least one cycle...
High-dose chemotherapy followed by autologous hematopoietic stem cell transplant (HSCT) is the treatment of choice for patients with relapsed and refractory (RR) lymphoma. We analyzed toxicity long-term outcome lomustine, cytarabine, cyclophosphamide, etoposide (LACE) conditioning in primary or lymphoma undergoing transplant.One-hundred (23), sensitive relapse (74) RR (3) Hodgkin (HL - 70 patients), non-HL (NHL 30 patients) underwent HSCT LACE (lomustine 200 mg/m 2 day-7, 1000 cytarabine...
There is paucity of data from India about the outcomes patients with various hematological malignancies. Since its formation in 2009, adult hematolymphoid disease management group Tata Memorial Centre dedicated to treatment malignancies alone. In this report, we present treated at our centre over a 5 year period for haematological both transplant and non-transplant setting.This retrospective analysis all registered between 1st January 2010 31st December 2014. Patients not were excluded...