A5044401924- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Retinoids in leukemia and cellular processes
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Cancer therapeutics and mechanisms
- Polyomavirus and related diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Mesenchymal stem cell research
Tata Memorial Hospital
2016-2025
Homi Bhabha National Institute
2020-2025
Advanced Centre for Treatment, Research and Education in Cancer
2016-2025
Post Graduate Institute of Medical Education and Research
2005-2009
Bristol Royal Hospital for Children
2006
All India Institute of Medical Sciences
2004-2006
DR. B.R.A. Institute Rotary Cancer Hospital
2004
Bosutinib, an orally active, Src/Abl tyrosine kinase inhibitor, has demonstrated clinical activity and acceptable tolerability in chronic phase myeloid leukemia (CP CML). This updated analysis of the BELA trial assessed safety profile management toxicities bosutinib versus imatinib adults with newly diagnosed (≤6 months) CP CML after >30 months from accrual completion. Among patients randomized to 500 mg/d ( n = 250) or 400 252), 248 251, respectively, received ≥1 dose study treatment....
Abstract We accrued 201 patients of adult AML treated with conventional therapy, in morphological remission, and evaluated MRD using sensitive error-corrected next generation sequencing (NGS-MRD) multiparameter flow cytometry (FCM-MRD) at the end induction (PI) consolidation (PC). Nearly 71% were PI NGS-MRD + 40.9% PC (median VAF 0.76%). had a significantly higher cumulative incidence relapse ( p = 0.003), inferior overall survival 0.001) free < as compared to − patients. was predictive...
There are sparse longitudinal data on SARS-CoV-2 infection after previous and partial or full vaccination.This study of a cohort healthcare workers used Kaplan-Meier analysis with appropriate definition events censoring Cox models to assess outcomes, cut-off June 18, 2021.A total 1806 individuals median age 32 (18-64) years, 1483 (82.1%) at least one vaccine dose, 1085 (60.1%) 2 doses, 408 (22.6%) episode infection, 6 (1.47%) episodes were included in the analysis. At follow-up 38.4 weeks...
Some children with relapsed or high-risk acute leukaemia have an improved outcome if they allogeneic stem cell transplant, preferably from a sibling well-matched unrelated donor. However, some do not these options there is urgent need to proceed transplant because of disease status. We investigated the role haploidentical family members as donors in 34 patients (median age 11 years, range 1-16 years). Patients were conditioned cyclophosphamide and total body irradiation (14.4 Gy eight...
Objective:The aim of the study was to introduce and evaluate compliance documentation situation, background, assessment, recommendation (SBAR) form.Methods:Twenty nurses involved in active bedside care were selected by simple random sampling. Use SBAR illustrated thru self-instructional module (SIM). Content validity reliability established. The form disseminated for use a clinical setting during shift handover. A retrospective audit undertaken at 1st week (A1) 16th (A2), post introduction...
A young boy developed steroid refractory GVHD post haploidentical transplant for relapsed B-ALL. He was on systemic immunosuppression with two immunosuppressants, and had history of CMV reactivation tuberculosis. Eight months post-transplant, he hospitalized multi-drug-resistant gram-negative sepsis, during the same episode, penile lesions which progressed to dry gangrene glans-penis. Fusarium grew in blood lesions. On retrospective thinking, it discerned that his onychomycoses were probable...
Abstract Background There is limited data on outcomes in cancer patients with coronavirus disease 2019 (COVID‐19) from lower middle‐income countries (LMICs). Patients and Methods This was an observational study, conducted between 12 April 10 June 2020 at Tata Memorial centre, Mumbai, undergoing systemic therapy laboratory confirmed COVID‐19. The objectives were to evaluate cumulative 30‐day all‐cause mortality, COVID‐19 attributable factors predicting time viral negativity after initial...
Background Recently, anti-CD38 monoclonal antibody (Mab) therapy has become a focus of attention as an additional/alternative option for many hematological neoplasms including T-cell acute lymphoblastic leukemia (T-ALL). It been shown that antitumor efficacy anti-CD38-Mab depends on the level CD38 expression tumor cells. Reports in T-ALL are scarce, and data effect cytotoxic chemotherapy limited to very few samples. Moreover, it lacks entirely refractory disease adult T-ALL. We report flow...
Abstract Background: Rituximab (Mabthera™) have been in use India since 2000. A biosimilar molecule of rituximab (Reditux™) was approved 2007. This retrospective audit done to compare the efficacy and safety Mabthera™ with Reditux™. Materials Methods: We reviewed charts 223 adult diffuse large B-cell lymphoma patients who had received cyclophosphamide, doxorubicin, vincristine prednisolone chemotherapy. Tumor recurrence, survival toxicities experienced during chemotherapy were obtained from...
Central venous catheters (CVCs) represent a significant source of infection in patients undergoing hematopoietic stem cell transplantation and can add to the cost care, morbidity, mortality. Organisms forming biofilms on inner surface require much higher local antibiotic concentration clear pathogen growth. Antibiotic lock therapy (ALT) represents one such strategy achieve high intraluminal concentrations antibiotics facilitate catheter salvage. Patients with colonization (CC) or...
Abstract The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results superior survival compared with the protocols. Pediatrics-inspired carry an increased risk toxicity treatment-related mortality low resource settings, which can offset potential benefits. We studied outcomes prognostic factors treatment AYA ALL a regimen. retrieved data regarding demographics, investigations, details, toxicities from electronic medical records...
Background Transplant related toxicity is a major therapeutic challenge. We have previously reported that the of chemotherapy largely not directly because drugs themselves; rather it mainly due to DNA damage, apoptosis and hyper-inflammation triggered by cell-free chromatin particles are released drug-induced host cell death. Cell-free can be inactivated free-radicals which generated when nutraceuticals resveratrol copper administered orally. investigated if combination would reduce...
The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeutic options for AML patients who progress on therapy, we studied clinical-stage CDK7 inhibitor XL102, which being evaluated solid tumors (NCT04726332).To determine anti-proliferative effects performed experiments including time-resolved fluorescence resonance energy transfer, target...
Detection of measurable residual disease (MRD) by mutation specific techniques has prognostic relevance in NPM1 mutated AML (NPM1mut AML). However, the clinical utility next generation sequencing (NGS) to detect MRD remains unproven. We analysed significance monitoring using ultradeep NGS (NGS-MRD) and flow cytometry (FCM-MRD) 137 samples obtained from 83 patients NPM1mut at end induction (PI) consolidation (PC). could monitor 12 different types mutations a sensitivity 0.001% NGS-MRD....
Background: Cytogenetics is one of the most important diagnostic parameters in classification acute leukemia. Recurrent chromosomal aberrations leukemia have provided insights into molecular mechanism leukemogenesis. The variable frequencies recurrent cytogenetic markers due to ethical/racial differences been reported from Western and some Asian countries. Objective: We report data largest cohort 7209 adult pediatric patients with de novo (AL) determine prevalence various sub groups compare...
Severe acute respiratory syndrome coronavirus 2 has caused substantial disruptions in routine clinical care. Emerging data show that surgery disease (COVID)-positive cases can be associated with worsening of outcomes and increased postoperative mortality. Hence, preoperative COVID-19 testing for all patients before elective was implemented our institution.Two hundred sixty-two asymptomatic cancer were preoperatively tested using reverse-transcription polymerase chain reaction technique...
Leukemia is majorly treated by topoisomerase inhibitors that induce DNA double strand breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders leukemic cells resistant to therapy. As we do not fully understand the regulation acquired cells, targeting these has been a challenge. Here investigated early drug population (EDRP) and late (LDRP). We found doxorubicin induced equal DSBs parent EDRP cells; however, death only cells. Further analysis revealed...
Highlights•This retrospective study was done to determine the utility of leflunomide in cytomegalovirus (CMV) reactivations after allogenic stem cell transplants. Leflunomide could clear CMV viremia 38% reactivation episodes.•CMV clearance rate best when copy number <2 × 103/mL compared with higher numbers (P= 0.022) and a pre-emptive setting. not beneficial once there end-organ involvement.•Being more effective at low burden, may have role as prophylactic agent haploidentical transplants,...