A5042039304- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Hematopoietic Stem Cell Transplantation
- Organ Transplantation Techniques and Outcomes
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- COVID-19 and healthcare impacts
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Resistance in Bacteria
- Tunneling and Rock Mechanics
- Phytochemicals and Medicinal Plants
- Organ and Tissue Transplantation Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiomics and Machine Learning in Medical Imaging
Homi Bhabha National Institute
2022-2025
Tata Memorial Hospital
2019-2025
Advanced Centre for Treatment, Research and Education in Cancer
2020-2025
Graft rejection is an important concern following haploidentical transplant with a reported incidence of 10-15%. The number human leukocyte antigen (HLA) mismatches and the vector mismatch have not been found to be associated risk graft in transplants. Patients HLA homozygosity at all loci (HLA-A, B, C, DRB1, DQB1) undergoing rare scenario that results zero graft-versus-host (GvH) direction 2-5 host-versus-graft (HvG) depending on donor haplotype. This heavily skewed unopposed...
Abstract The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results superior survival compared with the protocols. Pediatrics-inspired carry an increased risk toxicity treatment-related mortality low resource settings, which can offset potential benefits. We studied outcomes prognostic factors treatment AYA ALL a regimen. retrieved data regarding demographics, investigations, details, toxicities from electronic medical records...
Highlights•This retrospective study was done to determine the utility of leflunomide in cytomegalovirus (CMV) reactivations after allogenic stem cell transplants. Leflunomide could clear CMV viremia 38% reactivation episodes.•CMV clearance rate best when copy number <2 × 103/mL compared with higher numbers (P= 0.022) and a pre-emptive setting. not beneficial once there end-organ involvement.•Being more effective at low burden, may have role as prophylactic agent haploidentical transplants,...
Abstract The expression of CD20 in precursor B-cell acute lymphoblastic leukemia (B-ALL) is associated with poor outcomes. addition rituximab to intensive chemotherapy CD20+ ALL has led improved outcomes several studies. However, there no clear evidence regarding the optimal number doses and its benefit without an allogeneic stem cell transplant. Achieving measurable residual disease (MRD)-negative status postinduction would reduce requirement for a Novel approaches are needed induce higher...
Abstract Circulating tumor plasma cells (CTPCs) provide a noninvasive alternative for measuring burden in newly diagnosed multiple myeloma (NDMM). Moreover, measurable residual disease (MRD) assessment peripheral blood (PBMRD) can an ideal to bone marrow MRD, which is limited by its painful nature and technical challenges. However, the clinical significance of PBMRD NDMM still remains uncertain. Additionally, data on CTPC patients not treated with transplant are scarce. We prospectively...
Acute graft versus host disease (aGvHD) is the major contributor of nonrelapse mortality in alloHSCT. It associated with an inflammatory immune response manifesting as cytokine storm ensuing damage to target organs such liver, gut, and skin. Prevention aGvHD while retaining beneficial leukemia (GvL) effect remains a challenge. Withania somnifera extract (WSE) known for its anti-inflammatory, immune-modulatory, anticancer properties, which are appealing context aGvHD. Herein, we demonstrated...
The role of consolidation radiation therapy (CRT) after complete metabolic response to chemotherapy in advanced-stage (stage III and IV) Hodgkin lymphoma (HL) is controversial. This study was undertaken assess the clinical outcomes terms event free survival, local failure survival overall individuals with advanced HL treated CRT.
<title>Abstract</title> Globally, overall survival (OS) of older patients with AML continues to be suboptimal very little data from India. In a multicenter registry analysis, we evaluated 712 than 55 years. Only 323 (45.3%) underwent further treatment, which 239 (74%) received HMAs, and 60 (18%) intensive chemotherapy (IC). CR was documented in 39% those receiving IC 42% after HMAs. Overall, 100 (31%) died within days diagnosis, most commonly due progressive disease (47%) or infections...