A5100633397- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Retinoids in leukemia and cellular processes
- Tuberculosis Research and Epidemiology
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
Rajiv Gandhi Cancer Institute and Research Centre
2015-2024
Max Super Speciality Hospital
2023-2024
Menoufia University
2023
International Hospital of Bahrain
2022
Institute of Medical Sciences
2022
Bombay Hospital
2022
University of Veterinary and Animal Sciences
2020
National and Kapodistrian University of Athens
2017
Cancer Institute (WIA)
2017
Universitätsklinikum Tübingen
2017
Improving clinical outcomes among high risk Class III β thalassemia major patients (Class IIIHR) receiving an allogeneic SCT remains a challenge. From October, 2009 treosulfan based regimen (TreoFluT) was used for all consecutive (n = 50). The were compared with the historical conventional busulfan (BuCy) 139). Use of TreoFluT associated significantly reduced incidence sinusoidal obstruction syndrome (SOS) IIIHR cases (78% to 30%; P 0.000) and early TRM (46% 13%; p 0.005). There also trend...
Aim: Cytidine deaminase (CDA) irreversibly deaminates cytarabine (Ara-C), a key component of acute myeloid leukemia (AML) induction and consolidation therapy. CDA overexpression results in Ara-C resistance, while decreased expression is associated with toxicity. We evaluated factors influencing variation mRNA adult AML patients normal controls, how they contributed to cytotoxicity cells. Materials & methods: 100 de novo 36 controls were determined using quantitative reverse-transcriptase...
In addition to standard risk criteria at diagnosis, minimal residual disease (MRD) following initiation of therapy is a well-recognized factor predict relapse. Literature from developing countries addressing therapeutic or laboratory practices related MRD, largely lacking. first paper India, we describe our experience in establishing flow cytometry-based MRD assay for precursor B lineage ALL (BCP-ALL) with emphasis on the standardization and cost.Normal templates cell development were...
Data on convalescent plasma therapy (CPT) in patients of hematological malignancies with severe Covid-19 is scarce.
This study documents failure of peripheral tolerance mechanisms in a chronic viral infection and shows that T cell to Ag seen as self from fetal life can be broken despite the presence this extrathymic tissues. Congenital mice with lymphocytic choriomeningitis virus (LCMV) results virus. Such become carriers for harboring many tissues including thymus exhibit no LCMV-specific CTL responses. Our previous studies have documented curing congenitally acquired after adoptive transfer CD8+ cells...
Abstract Between 2001 and 2009, 121 patients with severe aplastic anemia ( SAA ) underwent hematopoietic stem cell transplantation HSCT using a conditioning protocol of fludarabine cyclophosphamide at three I ndian hospitals. Donors were HLA ‐identical sibling or family donors. Seventy‐six considered “high risk” as per criteria. The graft source included peripheral blood cells in 109 G ‐ CSF ‐stimulated bone marrow 12. GVHD prophylaxis consisted cyclosporine mini‐methotrexate. Engraftment...
In a first series from India, we report 9 cases of hepatosplenic T cell lymphoma (HSTCL) seen in 23 months accounting for 4.2% all mature T-non-Hodgkin lymphomas (NHLs) our institution. All patients presented with organomegaly, cytopenias and had evidence bone marrow involvement. The tumor cells blastic (55%) morphology predominantly intrasinusoidal (33.3%) or an additional interstitial component (33.3%). On flow cytometry, the classical phenotype (CD3+, CD7+, CD4−, CD8−, CD5−, CD56+/−) was...
<br><b>Background</b> : Chronic myelogenous leukemia (CML) is characterised by the t(9;22)(q34;q11.2) which results in formation of BCR/ABL1 fusion gene. Occasionally, t(9;22) may be associated with submicroscopic deletions chromosomes 9 and/or 22 appear to a worse prognosis. Three or four-way variant also occur. All these changes as well gain Philadelphia chromosome represents disease progression can detected fluorescence <i>in situ</i> hybridization (FISH) analysis. FISH analysis at...
Abstract Myeloma involving the laryngeal cartilage is rare, whereas extramedullary plasmacytoma only thyroid even rarer. No case of de novo has been published so far. Hence, it was a diagnostic challenge for clinicians, radiologists, and pathologists. Here, we presented 61-year-old man who had fixed right swelling. After 18 F-FDG PET/CT, biopsy, myeloma workup, found to be lamina. This highlighted rarity this presentation importance keeping in mind differential lead toward diagnosis.