Purpose of the Report Prostate-specific membrane antigen (PSMA) is a type II glycoprotein, which not only overexpressed in prostate cancers but also variety solid tumors including glioblastoma multiforme. The aim present study was to demonstrate PSMA expression gliomas using 68 Ga-PSMA-HBED-CC(PSMA 11) PET/CT. Patients and Methods Ten patients with initially MRI suspected eventually histopathologically proven [8 males (age range 30–73 yr; mean age 51.8 yr); 2 females aged 39 55 years] were...

Purpose of the Report Prostate-specific membrane antigen (PSMA) overexpression is not restricted to prostate cancer, but it has also been demonstrated in gliomas, lung and tumor neovasculature. Systematic studies exploring PSMA uptake thyroid tumors are lacking. The aim this pilot study was assess expression patients with metastatic differentiated cancer (mDTC). Materials Methods Ten mDTC harboring 32 lesions (5 men; age range, 38–65 years; mean age, 50 years) underwent prospective...

Introduction: 177 Lu-DOTATATE-based peptide receptor radionuclide therapy (PRRT) is a promising for metastatic and/or inoperable pheochromocytoma and paraganglioma (PPGL). We aim to evaluate the efficacy safety of identify predictors response Lu-DOTATATE in PPGL. Methods: This retrospective study involved 15 patients or unresectable PPGL, who received PRRT therapy. Clinical, biochemical (plasma-free normetanephrine), radiological (anatomical functional) responses were compared before after...

Gliomas are the most common primary central nervous system tumors, of which malignant gliomas account for 60%-75%. The and secondary brain malignancies highly treatment resistant, their marked angiogenesis attracts interest as a potential therapeutic target. grade gliomas, Ki-67 index, IDH mutation status among major prognostic markers in gliomas. Prostate-specific membrane antigen (PSMA) is zinc-dependent peptidase that not only expressed prostate cancer cells but also tumor neovasculature....

ABSTRACT The last mile is often subjected to unique challenges such as congested urban areas, unpredictable customer availability and the need for personalized services. To address these complexities, be competitive in market, companies are increasingly turning towards innovative solutions. One solution crowdshipping (CS). concept of CS was first introduced by Walmart 2013, where store customers may act crowdshippers fulfill demands online retailers or shops transporting packages on their...

The complementary role of multi-tracer PET in deciphering 2 different pathologies multiple endocrine neoplasia 1 (MEN-1) is illustrated this report. A 22-year-old man, with a history altered behavior over the past year and suspected to have hyperinsulinemic hypoglycemia based on positive 72-hour fasting test CT abdomen revealing lesion pancreas, was referred for 68 Ga-Exendin-4 PET/CT. Ga-Exendin PET/CT revealed focal uptake pancreatic lesion, Ga-DOTATATE did not show any avidity lesion;...

We present 2 cases, one with benign struma ovarii that was diagnosed preoperatively on Tc- 99 m and I-131 scans another of malignant peritoneal metastases were detected postoperatively 18 F-FDG PET/CT post-radioiodine (I-131) therapy scans. Benign ovarri had a rare occurrence coexisting Graves’ disease, while demonstrated involvement functional imaging. Even though rare, can contrasting features may require extensive workup, including radioiodine as shown in these cases.

A 62-year-old woman who experienced a seizure was found to be hypoglycemic. prolonged fasting test revealed raised critical insulin and C-peptide levels. CECT of the abdomen demonstrated an isodense focus in tail pancreas. On suspicion insulinoma, she referred for 68 Ga-Exendin-4 PET/CT study, which diffuse tracer uptake entire pancreatic tissue. She also underwent Ga-DOTATATE scan, physiological later tested positive anti-insulin antibodies. We herein report Exendin-4 study case autoimmune...

Purpose of the Report Prostate-specific membrane antigen (PSMA) is a member superfamily zinc-dependent exopeptidases that robustly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature including microvessels thyroid tumors. Its expression differentiated (DTC) has been confirmed many recent studies, but systematic studies exploring PSMA patients with DTC thyroglobulin elevation negative iodine scintigraphy (TENIS) are lacking. The aim present study was to evaluate...

Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance 68Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography (68Ga-DOTATATE PET/CT) from Asian-Indian subcontinent.In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed (CECT) 68Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, region-wise sensitivities 18F...

Background and aim This study aimed to examine the expression of RGD binding integrins in patients elevated serum thyroglobulin (Tg) level with negative radioiodine scintigraphy (TENIS) employing 68 Ga-NODAGA-RGD PET-CT. Material methods was a prospective involving 30 proven cases TENIS histopathological diagnosis differentiated thyroid carcinoma post-surgery. In addition observing lesional concentration on PET-CT, 4-point visual grading system (grade I–IV), undertaken estimate degree...

Osteosarcoma is the most common bone sarcoma in adolescents and children. Tumor thrombus arising from osteosarcoma rare. We describe case of a 13-year-old girl with right femur, whom F-NaF PET/CT was done for initial staging to look skeletal metastases. The scan showed abnormal increased tracer uptake primary tumor femoral external iliac vein representing thrombus. Our emphasizes importance extraosseous findings on PET/CT, which may result important management changes.

Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis, osteomas, and a multitude soft-tissue tumors. Dental anomalies are present in estimated 30% all affected individuals syndrome, so dental professionals play important role determining early signs syndrome. The intestinal polyps have 100% risk undergoing malignant transformation if not treated thus, diagnosis regular surveillance important. In this report, we describe classical presentation...

Background: Cisplatin and doxorubicin are integral components of chemotherapy regimens in the treatment osteosarcoma. Choice third agent high-dose methotrexate (HDMTX) or an alkylating such as ifosfamide is debatable. The present study compared impact MAP (HDMTX-doxorubicin-cisplatin) IAP (ifosfamide-doxorubicin-cisplatin) on toxicity survival children adolescents with Materials Methods: This was a retrospective including patients 18 years younger osteosarcoma during period. Clinical,...

Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms, with an almost exclusive propensity to arise from the minor glands. PLGA frequently manifests as asymptomatic, slow-growing mass within oral cavity, which must be separated adenoid cystic carcinoma and benign mixed tumor for therapeutic prognostic considerations. We report a case of 67-year-old male, who presented long-standing in palate. This lesion was diagnosed based on histopathological findings,...

<b><i>Introduction:</i></b> Core-needle biopsy (CNB) is a minimally invasive procedure used in preoperative diagnosis of breast lumps. It has been seen that few years, the CNB seems to be replacing fine-needle aspiration cytology (FNAC), although no study had yet conclusively proved superiority one over other. <b><i>Aims and Objectives:</i></b> The aim this was cytohistological spectrum palpable lesions evaluate diagnostic accuracy FNAC versus...

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Abstract Context Insulinoma needs accurate preoperative localization for minimally invasive surgery. Exendin‐4‐based imaging has shown promising results. Objective To evaluate performance parameters of exendin‐4‐based in insulinoma and compare with other modalities. Design Retrospective cross‐sectional study. Patients We report 14 patients endogenous hyperinsulinemic hypoglycaemia (EHH) managed at our centre; whom, the final diagnosis was (n = 11), Munchausen syndrome (MS) 2) inconclusive...

Literature regarding utility of 68 Ga-DOTATATE PET/CT in insulinoma localization across various subgroups [benign/malignant/multiple endocrine neoplasia-1 (MEN-1) syndrome associated] remains scarce. In this study, the performance was compared with contrast-enhanced computed tomography (CECT) and Ga-NODAGA-Exendin-4 (whenever available) an endogenous hyperinsulinemic hypoglycemia (EHH) cohort.Retrospective audit.EHH patients [N = 36, lesions (n) 49, final diagnosis: benign sporadic (BSI) (N...

Background: Palpable breast lumps are quite common which can be benign or malignant. Carcinoma is the second most cancer after cervical cancer. Fine needle aspiration cytology (FNAC) a minimally invasive, rapid, reliable and cost-effective outdoor procedure to provide effective diagnosis way further planning of treatment without need for biopsy. The objective study spectrum various lesions on cytomorphology its histopathological correlation. Methods: This was two years retrospective from...

Osteopetrosis also known as marble bone disease is a group of rare genetic disorders caused by osteoclast failure, which ranges widely in severity. presents with spectrum craniofacial abnormalities such frontal bossing, macrocephaly, hydrocephaly, and cranial hyperostosis. failure development or function mutations at least 10 genes have been identified causative humans, accounting for 70% all cases. These conditions can be inherited autosomal recessive, dominant X-linked traits the most...

Introduction: Cone beam computed tomography (CBCT) has been recognized as a reliable method for the examination of osseous components temporomandibular joint (TMJ). Aims and Objectives: The aim this study is to assess space arthritic changes in TMJ, visualized on CBCT scan. Materials Methods: comprised 60 patients attending outpatient department (120 joints) with dysfunction. All were subjected scan using Planmeca Promax 3D Mid machine. TMJ evaluation included bony (flattening, erosion,...

Radiolabelled metaiodobenzylguanidine (MIBG) is commonly used for imaging of neuroendocrine tumors (NETs). The hybrid with single photon emission computerized tomography/computerized tomography (SPECT/CT) co-registration can give that additional edge to this functional modality.To study the value (131)I-MIBG SPECT/CT scintigraphy in evaluation NETs.We performed a retrospective scintigraphic data patients referred our department detection and follow-up NETs from 2004 2008.Total number studies...