A5087233671- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Bone and Joint Diseases
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Blood properties and coagulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Retinoids in leukemia and cellular processes
- COVID-19 and healthcare impacts
Paras Hospitals
2023-2025
Max Super Speciality Hospital
2014-2023
Max Healthcare
2012-2021
Fortis Escorts Heart Institute
2021
Institute of Medical Sciences
2021
Synergy University
2021
Fortis Memorial Research Institute
2020
Campbell University
2020
University of Toronto
2012-2019
Hospital for Sick Children
2012-2019
Clostridioides difficile (C. difficile) infections are common in immunosuppressed patients. Sometimes these difficult to treat post-bone marrow transplant situations. A 2-year-old child with relapsed acute myeloid leukemia underwent a haploidentical bone transplant. He developed 30-40 episodes/day of loose watery stools on day +19. The stool was positive for C. infection. failed oral vancomycin and metronidazole therapy. received fecal microbiota (FMT) +43. donor the same sister who donated...
Abstract Objective Regular blood transfusions and secondary iron overload make thalassemic erythrocytes prone to peroxidative injury. Although some reports suggest endogenous free radical damage in thalassemia, there remains discrepancy the status of antioxidant enzymes. The aim this study was evaluate extent lipid peroxidation enzyme children with β‐thalassemia. Methods Fifty transfusion‐dependent β‐thalassemics were subjected analysis lipoperoxides as malondialdehyde (MDA), nitric oxide...
Summary. We investigated 52 of 457 patients with congenital factor deficiencies 57 episodes intracranial haemorrhage (ICH) between 1998 and 2007. There were 38 severe haemophiliacs, 6 XIII deficiency, 5 X 2 V‐deficient patients, 1 type 3 von Willebrand disease (VWD). The median age was 8 years (range month–22 years). Most below 15 (86.5%). All deficiency months age. ICH the primary bleeding episode leading to detection in 19.2% (five haemophilia all deficiency). Trauma caused 66%. None had...
Data on convalescent plasma therapy (CPT) in patients of hematological malignancies with severe Covid-19 is scarce.
Abstract: Deferiprone is now widely used for iron chelation in patients with thalassaemia. Studies on its efficacy and safety have largely included older children adults. Objective: To assess the of deferiprone <6 yr age. Methods: The study based scrutiny follow‐up data 44 age receiving a variable period time. Occurrence various side effects including gastrointestinal, osteoarticular were noticed complete blood counts performed every 2–4 wk. Results: Nausea vomiting 12 (27.2%), joint...
AbstractThrombotic events have been reported in adult thalassemic patients. To investigate this further, we measured hemostatic parameters children to identify possible predisposing factors early childhood. Objective: assess derangements polytransfused with beta-thalassemia major (beta-TM). Methods: Complete blood count, prothrombin time, activated partial thromboplastin protein C, S, Antithrombin III (AT III), fibrinogen, D-dimer assay, serum iron, ferritin and liver function tests were 54...
There is an association between inflammation and hemostatic changes that can result in a hypercoagulable state. We report 34-year-old male who presented with second episode of deep vein thrombosis. Tuberculosis was diagnosed while looking for secondary causes. The patient treated rifampicin, isoniazid, pyrazinamide ethambutol along low-molecular-weight heparin warfarin. has several mechanisms induce state lead to thromboembolic complications.
Autoimmune hemolytic anaemia (AIHA) is an uncommon cause of antibody-induced anemia in children. It divided into three categories: warm AIHA, cold antibody AIHA and paroxysmal hemoglobinuria. The diagnostic work-up typically begins with a peripheral smear direct antiglobulin test. Further approaches pathogenesis all entities are discussed. Clinical trials lacking for First-line therapy corticosteroids rituximab. Data on other therapeutic agents reviewed. Supportive care important aspect,...
We retrospectively analyzed 750 patients with ITP for development of intracranial hemorrhage (ICH). Seventeen cases age range 10 months to 18 years were studied. Ten acute and seven had chronic ITP. Nine developed ICH one month after the onset five on presentation. was precipitated by trauma in four possibly use NSAIDs patient. Median platelets counts at time 12 x 10(9)/L (range 2-50 10(9)/L). Most treated corticosteroids. Four (24%) died due ICH.
The clinico-hematological profile and treatment outcome of patients with autoimmune hemolytic anemia (AIHA) were assessed using a retrospective case record analysis. There 79 (52 primary; 27 secondary) consecutive identified median age 30.5 years. main presenting complaints pallor (94%), fever (46%), jaundice (51%), bleeding manifestations (10%) splenomegaly (68%). Jaundice was much more common in primary (63%) as opposed to secondary (26%) disease. direct antiglobulin test negative six...