A5013725004- Pregnancy and preeclampsia studies
- COVID-19 Clinical Research Studies
- Pelvic floor disorders treatments
- SARS-CoV-2 and COVID-19 Research
- Anorectal Disease Treatments and Outcomes
- Gestational Diabetes Research and Management
- Pelvic and Acetabular Injuries
- Hematopoietic Stem Cell Transplantation
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Long-Term Effects of COVID-19
- Parvovirus B19 Infection Studies
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- COVID-19 Impact on Reproduction
- Maternal and Perinatal Health Interventions
- Intensive Care Unit Cognitive Disorders
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Mobile Health and mHealth Applications
- Pneumonia and Respiratory Infections
- Hernia repair and management
Kathmandu University
2024
Dhulikhel Hospital
2024
Hinchingbrooke Hospital
2014-2023
Max Super Speciality Hospital
2011-2023
Max Healthcare
2020-2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
Intensive Care National Audit & Research Centre
2021
Public Health Scotland
2021
University Hospitals Birmingham NHS Foundation Trust
2021
This study aimed to determine the incidence and clinical outcomes for varying patterns of placental histological inflammation (consistent with fetal or maternal inflammatory response) in an unselected population >1000 women a singleton pregnancy resulting live birth delivering at near term. One thousand one hundred nineteen cases were studied blind, prospective, placentas categorized into five subgroups reflecting underlying response. Clinical included interventional delivery, Apgar score <7...
Antibodies against only about 25-28 blood group antigens are known to cause hemolytic reactions (HTRs), and red cell antibody screening should detect such clinically significant antibodies. An extension of the test is 'type screen' done antibodies, omiting anti-human globulin (AHG) cross-match.The aim this study was find out if type screen procedure a safe method for pre-transfusion testing when compared AHG cross-match currently in use India.We evaluated data from 45373 patients whom total...
Transfusion transmittable infections (TTI) continue to be a major threat safe transfusion practices. Blood is one of the sources transmission infectious diseases viz. human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), syphilis, malaria, and many other in India. Screening assays for with excellent sensitivity specificity helps enhance safety blood transfusions reducing diagnostic window period as much possible.The present study was designed determine seroprevalence TTIs viz.,...
To assess whether the introduction of episiotomy scissors specially designed to achieve a cutting angle 60°, EPISCISSORS-60(®), in two hospitals UK would result reduction obstetric anal sphincter injuries (OASIS) nulliparous women.A structured training program for all doctors and midwives provided theoretical framework around OASIS including risk factors role episiotomies practical hands-on element use EPISCISSORS-60(®) correctly measure perineal body length post-suturing angles. Data...
Complementary therapy and Alternative medicine (CAM) is used worldwide for many ailments a popular option amongst pregnant women general wellbeing managing symptoms. Many studies investigating the use of CAM in antenatal intrapartum period have been conducted however there lack evidence regarding its effects on induction labour delivery. We established post-dates clinic comprising an check low risk to determine impact these outcomes.This was cohort study with convenience sampling. A total...
Pandemic SARS-CoV-2 is the third Coronavirus to cause severe respiratory illness in humans. Little known about effects on pregnant women and question of whether vertical transmission can occur remains unanswered controversial. Universal screening has been described literature however date universal newborns not. Here we report our unusual findings results a programme asymptomatic healthy mothers together with their . Our Trust, delivery rate 7300 births per year, introduced nasopharyngeal...
Objective. A few recent studies have investigated the relationship between birth weight and digitally derived placental dimensions, no standardised methodology has been used. The aims of this study are to compare manually measurements with those establish circumference.Methods. Three hundred fifty-one consecutive unselected women singleton pregnancy delivering in a tertiary maternity unit at 37–42 weeks were recruited. Manual digital axis (using calibrated imaging 'Image J' software)...
The concept of gene therapy dates back to the 1960s and 1970s it is yet come age, as there a paucity reliable, long-term data on safety efficacy this novel therapy. It fast emerging promising approach treat, cure or prevent genetic based diseases by correction defective genes that are responsible for disease development. Gene key treatment strategy disorders caused missing faulty gene. involves introduction functional into appropriate cells so they can produce sufficient amounts proteins,...
Background: Early T-cell precursor acute lymphoblastic leukemia (ETP ALL) is a high-risk subgroup of characterized by unique immune phenotype and disease biology. ETP ALL cells share similarities with hematopoietic stem myeloid progenitor cells. These patients have lower rates complete remission overall survival. High BCL2 expression the main rationale for using venetoclax in ALL. Results: We report treatment outcomes 2 who achieved minimal residual negative short course venetoclax....
Abstract Leukocyte migration inhibitory factor (LIF) is produced by lymphocytes with receptors specific to sensitizing antigens. This principle was used detect possible antigenic differences between sperm of autoimmune and nonautoimmune men. Sixteen fertile 91 infertile couples were screened for cytotoxic hemagglutinating antibodies from their husbands controls. Their tested the production LIF extracts seminal plasma controls a direct leukocyte inhibition assay. Twenty-nine 35 men producing...
This case report describes a woman who developed involuntary, uncoordinated movements of her face and limbs following spontaneous vaginal delivery, complicated by postpartum haemorrhage. Using systematic assessment with multidisciplinary team input, differential diagnosis was proposed relevant investigations were undertaken. Atypical eclamptic or generalised seizures excluded clinically neuroimaging ruled out an intracranial vascular event such as stroke venous sinus thrombosis. Local...