A5103037642- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Congenital Heart Disease Studies
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Pharmacological Effects and Toxicity Studies
- T-cell and B-cell Immunology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Transplantation Outcomes and Treatments
- Epilepsy research and treatment
- Hemophilia Treatment and Research
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- Parvovirus B19 Infection Studies
- Neuroscience and Neuropharmacology Research
- Neonatal Health and Biochemistry
- Iron Metabolism and Disorders
- Tracheal and airway disorders
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2017-2024
Otemae Hospital
2021
All India Institute of Medical Sciences
2010-2016
All India Institute of Medical Sciences Bhopal
2016
All India Institute of Medical Sciences Raipur
2016
JSS Medical College and Hospital
2015
JSS Academy of Higher Education and Research
2015
Christian Medical College
1997-2015
Christian Medical College & Hospital
1997-2015
Post Graduate Institute of Medical Education and Research
2013-2014
Autoimmune hemolytic anaemia (AIHA) is an uncommon cause of antibody-induced anemia in children. It divided into three categories: warm AIHA, cold antibody AIHA and paroxysmal hemoglobinuria. The diagnostic work-up typically begins with a peripheral smear direct antiglobulin test. Further approaches pathogenesis all entities are discussed. Clinical trials lacking for First-line therapy corticosteroids rituximab. Data on other therapeutic agents reviewed. Supportive care important aspect,...
ABSTRACT Background: Recurrent somatic mutations in the JAK2 , CALR and MPL genes are noted BCR:ABL1 negative classic myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET), primary myelofibrosis (PMF). Materials Methods: Mutation profile clinical features of MPN cases diagnosed at a tertiary care center North India being described. JAK2V617F mutation was screened using ARMS PCR, allele-specific PCR followed by fragment analysis. Exon 12 were...
Abstract Background Recently, CD26 have been identified as one of the promising and specific marker for identification leukemic stem cells (LSCs) in chronic myeloid leukemia (CML). Methods This was a prospective, observational validation study. Peripheral blood (PB) samples from suspected cases CML other hematolymphoid neoplasm were evaluated expression on (SC) (CD45 dim/CD34+/CD38‐) fraction by flow cytometry (FCM) using single tube four‐color antibodies cocktail: CD45‐V500...
Currently, more than 10,000 matched unrelated donor transplants (MUDT) are performed annually worldwide. India has recorded a significant increase in the number of hematopoietic progenitor cell transplantation (HPCT) centers reporting transplants. The HPCTs increases by approximately 10% every year, with 1878 reported Indian stem transplant registries 2016. However, published outcome data MUDT scant, reports limited to autologous and allogenic transplants, which motivated us present our...
Abstract Introduction MicroRNAs (miRNAs) play a critical role in orchestrating T cell differentiation and activation may thus vital acquired aplastic anemia (aAA). The study aimed to evaluate the differential expression of selected miRNAs their relevant target genes bone marrow samples aAA patients. Methods Differential 8 viz; hsa‐miR‐126‐3p, miR‐145‐5p, miR‐155‐5p, miR‐150‐5p, miR‐146b‐5p, miR‐34a, miR‐29a, miR‐29b was evaluated mononuclear cells TaqMan microRNA assay performed for...
The anatomical variability in patients with anomalous pulmonary venous connection to superior vena cava presents a surgical challenge. problem is further compounded by the common occurrence of postoperative complications like arrhythmias and obstruction or veins. We present our experience managing this subset using two patch Warden's techniques. Between June 2011 September 2012, 7 APVC SVC were operated institute. After delineating anatomy, five them had repair managed technique. There was...
Background: DNA methylation plays a vital role in the pathogenesis of myelodysplastic syndrome (MDS), heterogeneous group clonal hematopoietic stem cell (HSC) disorders. It is reported to be an independent prognostic factor affecting overall survival (OS). Our aim was analyze global using anti-5-methylcytosine (5-MC) antibody by immunohistochemistry (IHC) bone marrow biopsy (BM Bx) specimens MDS patients, assessing correlations with various clinical and biological factors. Material methods:...
Bilateral patent ductus arteriosus (PDA) is a rare congenital anomaly and vital for survival in complex like non-confluent pulmonary artery (PA), severe coarctation of aorta, interrupted aortic arch hypoplastic left arch.We report patient with arteries associated atresia, double outlet right ventricle (DORV), ventricular septal defect (VSD), bilateral superior vena cavae (SVC).This required different surgical strategy due to presence univentricular physiology non -confluent PA, which...
Histocompatibility testing is pivotal in any renal transplantation workup, aimed at enhancing prospective donor recipient compatibility and improving transplant outcomes. The evolution advancement of histocompatibility testing, particularly HLA typing, have significantly improved its precision. This study outlines the historical progression from serologic to DNA-based emphasizing role proteins immune response. Anti-HLA antibodies, targeting proteins, pose challenges transplantation....
ABSTRACT Background δβ‐thalassemia/HPFH is an uncommon hemoglobinopathy characterized by decreased or the total absence of production δ‐ and β‐globin increased HbF levels. Both these disorders have variable genotype phenotype, but significant overlap in clinical laboratory findings. Given lack literature this regard, study aimed to estimate prevalence disease evaluate its clinical, hematological, molecular profile India. Material Methods This was a retrospective where all samples with level...
The authors describe 10 cases of myelofibrosis diagnosed and managed at their center over 16 years. There were 2 8 cases, respectively, primary secondary myelofibrosis. All patients presented with fever, pallor, hepatosplenomegaly, and/or lymphadenopathy. Hodgkin's lymphoma (n = 4), neuroblastoma 1), thrombasthenic thrombopathy retroperitoneal-mass 1) causal in 7 patients, whereas the diagnosis could not be established a sole case Patients chemotherapy appropriate care. However, outcome was...