A5053748601- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Medical Imaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Ocular Oncology and Treatments
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Hedgehog Signaling Pathway Studies
- Oral and Maxillofacial Pathology
- Vascular Malformations Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Functional Brain Connectivity Studies
- Lung Cancer Diagnosis and Treatment
- Neurological Complications and Syndromes
Homi Bhabha National Institute
2019-2025
Tata Memorial Hospital
2019-2025
Advanced Centre for Treatment, Research and Education in Cancer
2021-2024
Elucid Bioimaging
2020
King Edward Memorial Hospital and Seth G.S. Medical College
2015
Indian Institute of Technology Dhanbad
2014
Grading of gliomas is a piece critical information related to prognosis and survival. Classifying glioma grade by semantic radiological features subjective, requires multiple MRI sequences, quite complex clinically demanding, can very often result in erroneous diagnosis. We used radiomics approach with machine learning classifiers determine the gliomas. Eighty-three patients histopathologically proven underwent brain. Whenever available, immunohistochemistry was additionally augment...
Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation-induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess efficacy oral CHL for treatment brain radionecrosis patients with diffuse glioma. is a phase 2 trial prospective, interventional study. Adults (> 18 years) histological diagnosis glioma developing will be eligible Radionecrosis identified using standard imaging protocols magnetic resonance...
Background: Radiation therapy (RT) for postoperative residual or progressive non-functioning pituitary adenomas (NFPAs) has excellent long-term local control (LC) although its use been limited because of the potential late toxicity related to radiation treatments. Newer techniques have led better precision. Objective: The objective study was review institutional outcomes NFPA treated with RT. Methods and Materials: One hundred forty-seven patients were at our institution from 2006 2018....
The interactions between an anionic surfactant, viz., sodium dodecylbenzenesulfonate and nonionic surfactants with different secondary ethoxylated chain length, Tergitol 15-S-12, 15-S-9, 15-S-7 have been studied in the present article. An attempt has also made to investigate effect of length on micellar thermodynamic properties mixed surfactant systems. like critical micelle concentration (CMC), composition (XA), interaction parameter (β), activity coefficients (fA fNI) evaluated using...
Primary intracranial germ cell tumors (ICGCTs) are rare and histologically classified as germinomas non-germinomatous with distinctive prognostic therapeutic implications. ICGCTs, essentially due to the inherent difficulty of surgical access, pose different challenges management connotations than their extracranial counterparts. This is a retrospective analysis verified which was undertaken evaluate various clinicopathological features implications on patient management.Eighty-eight...
Highergrade glial neoplasms undergo standard treatment with surgery, radiotherapy, and alkylating agents. There is often a clinical/neuroimaging dilemma in the post-treatment setting to differentiate disease recurrence from treatment-related changes. FET (fluoro-ethyl-tyrosine) PET has emerged as molecular imaging modality for cases where MR inconclusive. This study aims develop cutoff on differentiating true changes.We retrospectively analyzed72 patientswith grade 3 or 4 brain gliomas. Five...
Abstract Oral cavity cancers contribute to a majority of in India. Clinical examination alone cannot determine the deeper extent disease; therefore, need for cross-sectional imaging including computed tomography and magnetic resonance becomes indispensable pre-treatment evaluation decide optimal plan management. squamous cell (OSCC) can be treated with surgery alone, whereas deep muscle, neurovascular, osseous, or nodal involvement on suggests advanced disease that requires combination...
Pleomorphic adenomas (PA) are the most common type of salivary gland tumors. These slow-growing benign tumors commonly involve parotid gland, but can sometimes occur at atypical sites such as submandibular or minor glands. We describe an case pleomorphic adenoma with multicentric involvement parotid, and parapharyngeal space in a 35-year-old male which mimicked slow-flow malformation on magnetic resonance imaging (MRI). Diagnosis was confirmed fine needle aspiration cytology, conservative...
Surgical resection of insular gliomas is a challenge. TO considered more versatile and has lower risk vascular damage. In this study, we aimed to understand the factors that affect rates, ischemic changes neurological outcomes studied utility IONM in patients who underwent for IGs. Retrospective analysis 66 with IG was performed. Radical possible 39% patients. Involvement zone II absence contrast enhancement predicted rate. Persistent deficit rate 10.9%. Although dominant lobe tumors...
Abstract BACKGROUND Pediatric Low-Grade Gliomas (PLGG), encompass a heterogenous set of tumours, with upregulation RAS/MAPK pathway, making them amenable to therapeutic targeting. MEK inhibitors are emerging as promising alternative conventional chemotherapy strategies which have modest efficacy significant toxicity/hospitalisation and hence long periods stay away from home (& school). Recently, we transitioned use inhibitors, where feasible, in children PLGG. METHODOLOGY Retrospective...
Semantic imaging features have been used for molecular subclassification of high-grade gliomas. Radiomics-based prediction subgroups has the potential to strategize and individualize therapy. Using MRI texture features, we propose distinguish between IDH wild type mutant high grade gliomas.Between 2013 2020, 100 patients were retrospectively analyzed radiomics study. Immunohistochemistry pathological specimen was initially identify mutant/wild phenotype then confirmed by Sanger's sequencing....
Image-based prediction of molecular subgroups Medulloblastoma (MB) has the potential to optimize and personalize therapy. The objective study is distinguish between broad MB using MR-Texture analysis.Thirty-eight patients treated 2007 2020 were retrospectively analyzed. Texture analysis was performed on contrast enhanced T1(T1C) T2 weighted (T2W) MR images. Manual segmentation all slices radiomic features extracted which included first order, second order (GLCM - Grey level co-occurrence...
Abstract Background We present our institutional approach for re-irradiation in diffuse intrinsic pontine glioma and their outcomes. Methods Consecutive patients of recurrent treated with (January 2015–September 2019) were reviewed retrospectively to describe the clinical-response-based followed dose volume decision. Outcomes defined clinical steroid response criteria survival endpoints included progression-free overall as cumulative(c) (re-irradiation starting death). The Kaplan–Meier...
Abstract We discussed the imaging recommendations for diagnosis, staging, and management of larynx hypopharynx cancer. Carcinoma is a common cancer, with males being affected more. Hypopharyngeal carcinoma less than laryngeal malignancies. Squamous cell most histological type. Nonsquamous malignant lesions are rare mostly submucosal lesions. Clinical examination endoscopy play an integral role in its detection staging. Imaging also plays major including local disease extent, nodal distant...
Abstract Thyroid cancer ranks as the leading endocrine malignancy in adults. The foundation for primary diagnosis of thyroid is a high-resolution ultrasound (US) gland including US-guided fine-needle biopsy (FNB) suspected nodules. Advanced cross-sectional imaging, computed tomography (CT), magnetic resonance and positron emission tomography, can be useful selected patients. mainstay treatment surgery. It may supplemented by radioactive iodine ablation/therapy high-risk differentiated...
Medulloblastoma (MB) comprises four broad molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and 4, respectively, with subgroup-specific developmental origins, unique genetic profiles, distinct clinico-demographic characteristics, diverse clinical outcomes. This is a retrospective audit of outcomes in molecularly confirmed WNT-MB patients treated maximal safe resection followed by postoperative standard-of-care risk-stratified adjuvant radio(chemo)therapy at...
Abstract Constitutional mismatch repair deficiency (CMMRD) is a rare childhood cancer predisposition syndrome that results from biallelic germline mutations in one of the four MMR genes, MLH1, MSH2, MSH6, or PMS2. This characterized by broad spectrum early-onset malignancies, including hematologic colorectal brain tumors, and other malignancies. It common to have more than malignancy an individual diagnosed with CMMRD. In addition primary immunodeficiency form low absent immunoglobulin...
Conventional magnetic resonance imaging (MRI) has limitations in differentiating tumor recurrence (TR) from radionecrosis (RN) high-grade gliomas (HGG), which can present with morphologically similar appearances. Multiparametric advanced MR sequences and Positron Emission Tomography (PET) amino acid tracers aid diagnosing metabolism. The role of both modalities on an individual basis combined performances were investigated the current study.
Background: Medulloblastoma (MB) comprises four broad molecular subgroups - wingless (WNT), sonic hedgehog (SHH), Group 3, and 4 respectively with subgroup-specific developmental origins, unique genetic profiles, distinct clinico-demographic characteristics, diverse clinical outcomes. WNT-MB has the best outcomes (5-year survival >90%) contemporary multi-modality treatment prompting attempts at de-intensification to reduce late toxicity. This is a retrospective audit of in patients...