A5090905342- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Neurofibromatosis and Schwannoma Cases
- Breast Lesions and Carcinomas
- Chromatin Remodeling and Cancer
- Ocular Oncology and Treatments
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- AI in cancer detection
- Lymphoma Diagnosis and Treatment
- Digital Imaging in Medicine
Tata Memorial Hospital
2017-2025
Homi Bhabha National Institute
2019-2025
Advanced Centre for Treatment, Research and Education in Cancer
2018-2025
Grading of gliomas is a piece critical information related to prognosis and survival. Classifying glioma grade by semantic radiological features subjective, requires multiple MRI sequences, quite complex clinically demanding, can very often result in erroneous diagnosis. We used radiomics approach with machine learning classifiers determine the gliomas. Eighty-three patients histopathologically proven underwent brain. Whenever available, immunohistochemistry was additionally augment...
The COVID-19 pandemic accelerated the widespread adoption of digital pathology (DP) for primary diagnosis in surgical pathology. This paradigm shift is likely to influence how we function routinely postpandemic era. We present learnings from early DP a live sign-out home risk-mitigated environment.We aimed validate remote reporting real-time environment and evaluate parameters influencing efficiency workflow. Eighteen pathologists prospectively validated use on 567 biopsy cases including 616...
Introduction: Idiopathic granulomatous mastitis (IGM) is a benign, chronic inflammatory disease with no effective treatment and high relapse rate. The pathophysiology poorly understood. Tinosporin, an immunomodulator obtained from Tinospora cordifolia, known to be useful in treating immune-mediated diseases. We report our experience of using Tinosporin for IGM the effectiveness this "steroid-free" regimen. Methods: analysed clinicopathological characteristics patients diagnosed on...
Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation-induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess efficacy oral CHL for treatment brain radionecrosis patients with diffuse glioma. is a phase 2 trial prospective, interventional study. Adults (> 18 years) histological diagnosis glioma developing will be eligible Radionecrosis identified using standard imaging protocols magnetic resonance...
Background: Radiation therapy (RT) for postoperative residual or progressive non-functioning pituitary adenomas (NFPAs) has excellent long-term local control (LC) although its use been limited because of the potential late toxicity related to radiation treatments. Newer techniques have led better precision. Objective: The objective study was review institutional outcomes NFPA treated with RT. Methods and Materials: One hundred forty-seven patients were at our institution from 2006 2018....
Medulloblastoma is uncommon and molecularly lesser known in adults than their pediatric counterparts. This study aims to describe the clinicopathological molecular characteristics of medulloblastoma adults. Methods . The clinical, histopathological, features 113 patients >18 years age were reviewed. Molecular grouping (wingless pathway activated [WNT]-activated, sonic hedgehog [SHH]-activated, non-WNT/non-SHH, Group 3 4) was done by gene expression profiling. Results age-range 19 59...
Highergrade glial neoplasms undergo standard treatment with surgery, radiotherapy, and alkylating agents. There is often a clinical/neuroimaging dilemma in the post-treatment setting to differentiate disease recurrence from treatment-related changes. FET (fluoro-ethyl-tyrosine) PET has emerged as molecular imaging modality for cases where MR inconclusive. This study aims develop cutoff on differentiating true changes.We retrospectively analyzed72 patientswith grade 3 or 4 brain gliomas. Five...
Primary intracranial germ cell tumors (ICGCTs) are rare and histologically classified as germinomas non-germinomatous with distinctive prognostic therapeutic implications. ICGCTs, essentially due to the inherent difficulty of surgical access, pose different challenges management connotations than their extracranial counterparts. This is a retrospective analysis verified which was undertaken evaluate various clinicopathological features implications on patient management.Eighty-eight...
Aim: To prospectively assess the clinical utility of pretreatment flouro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with primary central nervous system (CNS) lymphoma (PCNSL). Materials & methods: Patients suspected/proven PCNSL underwent baseline whole-body 18F-FDG-PET/CT. Maximum standardized uptake value and tumor/normal tissue ratios were compared between CNS other histological diagnoses. Results: The mean maximum (27.5 vs 18.2; p = 0.001)...
Semantic imaging features have been used for molecular subclassification of high-grade gliomas. Radiomics-based prediction subgroups has the potential to strategize and individualize therapy. Using MRI texture features, we propose distinguish between IDH wild type mutant high grade gliomas.Between 2013 2020, 100 patients were retrospectively analyzed radiomics study. Immunohistochemistry pathological specimen was initially identify mutant/wild phenotype then confirmed by Sanger's sequencing....
Despite increasing interest in whole-slide imaging (WSI) over optical microscopy (OM), limited information on comparative assessment of various digital pathology systems (DPSs) is available.A comprehensive evaluation was undertaken to investigate the technical performance-assessment and diagnostic accuracy four DPSs with an objective establish noninferiority WSI OM find out best possible DPS for clinical workflow.A total 2376 images, 15,775 image reads (OM - 3171 + 12,404), 6100 1245, 4855)...
Abstract BACKGROUND Pediatric Low-Grade Gliomas (PLGG), encompass a heterogenous set of tumours, with upregulation RAS/MAPK pathway, making them amenable to therapeutic targeting. MEK inhibitors are emerging as promising alternative conventional chemotherapy strategies which have modest efficacy significant toxicity/hospitalisation and hence long periods stay away from home (& school). Recently, we transitioned use inhibitors, where feasible, in children PLGG. METHODOLOGY Retrospective...