A5032979380- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
- Ferroptosis and cancer prognosis
- Bone Tumor Diagnosis and Treatments
- Nanoplatforms for cancer theranostics
- Ocular Oncology and Treatments
- Chromatin Remodeling and Cancer
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Brain Tumor Detection and Classification
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
Tata Memorial Hospital
2016-2025
Advanced Centre for Treatment, Research and Education in Cancer
2016-2025
Homi Bhabha National Institute
2018-2025
Mayo Clinic Hospital
2024
Bombay Hospital
2013
King Edward Memorial Hospital and Seth G.S. Medical College
2013
German Cancer Research Center
2013
Heidelberg University
2013
Emory University
2012
University of Toronto
2012
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on clinical parameters inadequate for accurate prognostication. MicroRNA expression known to be deregulated various cancers and has been found useful predicting behavior. In order get better understanding of medulloblastoma biology, miRNA profiling medulloblastomas was carried out parallel with protein-coding genes.miRNA using Taqman Low Density Array v 1.0 having 365 human...
Glioblastoma is a WHO grade IV brain tumor, which leads to poor overall survival (OS) of patients. For precise surgical and treatment planning, OS prediction glioblastoma (GBM) patients highly desired by clinicians oncologists. Radiomic research attempts at predicting disease prognosis, thus providing beneficial information for personalized from variety imaging features extracted multiple MR images. In this study, first-order, intensity-based volume shape-based textural radiomic are...
Gliomas are the most common primary brain malignancies, with varying degrees of aggressiveness and prognosis. Understanding tumor biology intra-tumor heterogeneity is necessary for planning personalized therapy predicting response to therapy. Accurate tumoral intra-tumoral segmentation on MRI first step toward understanding through computational methods. The purpose this study was design a algorithm evaluate its performance pre-treatment MRIs obtained from patients gliomas.
Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation-induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess efficacy oral CHL for treatment brain radionecrosis patients with diffuse glioma. is a phase 2 trial prospective, interventional study. Adults (> 18 years) histological diagnosis glioma developing will be eligible Radionecrosis identified using standard imaging protocols magnetic resonance...
Medulloblastoma has recently been found to consist of 4 molecularly and clinically distinct subgroups: WNT, Sonce hedgehog (SHH), Group 3, 4. Deregulated microRNA expression is known contribute pathogenesis shown have diagnostic prognostic potential in the classification various cancers. Molecular subgrouping analysis 44 frozen 59 formalin-fixed paraffin embedded medulloblastomas from an Indian cohort were carried out by real-time RT-PCR assay. The differential 9 microRNAs molecular...
Understanding of molecular events underlying resistance and relapse in glioblastoma (GBM) is hampered due to lack accessibility resistant cells from patients undergone therapy. Therefore, we mimicked clinical scenario an vitro cellular model developed five GBM grade IV primary patient samples two cell lines. We show that upon exposure lethal dose radiation, a subpopulation cells, innately survive transiently arrest G2/M phase via inhibitory pCdk1(Y15). Although arrested, these multinucleated...
Novel biological insights have led to consensus classification of medulloblastoma into 4 distinct molecular subgroups-wingless (WNT), sonic hedgehog (SHH), Group 3, and 4. We aimed predict subgrouping in based on preoperative multiparametric magnetic resonance imaging (MRI) characteristics.A set 19 MRI features were evaluated 111 patients with histologic diagnosis for prediction subgrouping. characteristics correlated subgroups derived from tissue samples (WNT = 17, SHH 44, 3 27, 23)....
Background: Overburdened systems and concerns of adverse outcomes have resulted in deferred cancer surgeries with devastating consequences. In this COVID pandemic, the decision to continue elective surgeries, their subsequent outcomes, are sparsely reported from hotspots. Methods: A prospective database Department Surgical Oncology was analysed March 23rd April 30th, 2020. Findings: Four hundred ninety-four were performed (377 untested 117 tested for Covid 19 before surgery). Median age 48...
Over the last 2 decades, transnasal endoscopic surgery (TES) has become most frequently employed surgical technique to treat sinonasal malignancies. The rarity and heterogeneity of cancers have hampered large non-population-based analyses.All patients receiving TES-including treatment between 1995 2021 in 5 referral hospitals were included. A prognostic study was performed, multivariable models transformed into nomograms. Training validation sets based on results from 3 European non-European...
Glioblastoma multiforme ( GBM ) or grade IV astrocytoma is the most common and lethal adult malignant brain tumor. The present study was conducted to investigate alterations in serum proteome patients compared healthy controls. Comparative proteomic analysis performed employing classical 2DE 2D‐DIGE combined with MALDI TOF/TOF MS results were further validated through Western blotting immunoturbidimetric assay. Comparison of subjects revealed 55 differentially expressed statistically...
ABSTRACT Background: Localization and delineation of extent lesions is critical for safe maximal resection brain spinal cord tumors. Frame-based frameless stereotaxy intraoperative MRI are costly not freely available especially in economically constrained nations. Intraoperative ultrasound has been around a while but relegated to the background. Lack objective evidence its usefulness perceived “user unfriendliness” US probably responsible this. We recount our experience with this “forgotten”...
BACKGROUND: To describe therapeutic approaches in children with atypical Teratoid Rhabdoid Tumours (ATRT) France.METHODS: Observational study including all less than 18 years old diagnosed ATRT France between 2009 and 2011.RESULTS: Forty seven were included this retrospective study.Six patients received no curative treatment while forty-one had a project.Median age was 1.5 (range 0-16).The disease disseminated 10 patients.Surgical resection complete 21 cases.Chemotherapy administered 41...
The heterogeneity and poor prognosis associated with gliomas, makes biomarker identification imperative. Here, we report autoantibody signatures across various grades of glioma serum samples sub-categories glioblastoma multiforme using Human Proteome chips containing ~17000 full-length human proteins. deduced sets classifier proteins helped to distinguish Grade II, III IV from the healthy subjects 88, 89 94% sensitivity 87, 100 73% specificity, respectively. Proteins namely, SNX1, EYA1,...
Abstract Meningiomas are the most common non-glial tumors of brain and spine. Pathophysiology definite histological grading meningiomas frequently found to be deceptive due their unusual morphological features locations. Here for first time we report a comprehensive serum proteomic analysis different grades by using multiple quantitative immunoassay-based approaches obtain mechanistic insights about disease pathogenesis identify grade specific protein signatures. In silico functional...
OBJECTIVE Navigated 3D ultrasound is a novel intraoperative imaging adjunct permitting quick real-time updates to facilitate tumor resection. Image quality continues improve and currently sufficient allow use of navigated (NUS) as stand-alone modality for guidance without the need preoperative MRI. METHODS The authors retrospectively analyzed cases involving operations performed at their institution in which navigation system was used control resection brain tumors “direct” mode, MRI...
Abstract Background Residual disease of glioblastoma (GBM) causes recurrence. However, targeting residual cells has failed, due to their inaccessibility and our lack understanding survival mechanisms radiation therapy. Here we deciphered a cell–specific mechanism essential for GBM relapse. Methods Therapy resistant (RR) were captured from primary patient samples cell line models mimicking clinical scenario resistance. Molecular signaling resistance in RR was identified using RNA sequencing,...
Meningiomas (MGs) are frequent tumors of the CNS originating from meningeal layers spinal cord and brain. In this study, comparative tissue proteomic analysis low high grades MGs was performed by using iTRAQ-based quantitative proteomics in combination with ESI-quadrupole-TOF Q-Exactive MS, results were validated employing ELISA. Combining obtained two MS platforms, we able to identify overall 4308 proteins (1% false discover rate), among which 2367 exhibited differential expression (more...
BackgroundSurgical site infections are a threat to patient safety. However, in India, data on their rates stratified by surgical procedure not available.