A5087015391- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Digital Imaging in Medicine
- Radiation Dose and Imaging
- Pharmaceutical Economics and Policy
- Lung Cancer Diagnosis and Treatment
- COVID-19 and Mental Health
- Medical Imaging Techniques and Applications
- Reconstructive Surgery and Microvascular Techniques
- BRCA gene mutations in cancer
Tata Memorial Hospital
2016-2025
Homi Bhabha National Institute
2019-2025
Advanced Centre for Treatment, Research and Education in Cancer
2011-2024
ORCID
2023
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
University of Lübeck
2017
Morristown Medical Center
2012
Thomas Jefferson University Hospital
2012
Background Health technology assessment (HTA) is a valuable tool for informing the efficient allocation of resources in healthcare. However, resource-intensive nature HTA can limit its application, especially low-resource settings. Adapting processes by assessing available international evidence offers pragmatic approach to provide decision-making where are constrained. Objective This study piloted an adaptive (aHTA) method evaluate 10 cancer interventions. Methods We arranged joint...
Available data on cost of cancer treatment, out-of-pocket payment and reimbursement are limited in India. We estimated the treatment costs, payment, a cohort breast patients who sought at publicly funded tertiary care hospital A prospective longitudinal study was conducted from June 2019 to March 2022 Tata Memorial Centre (TMC), Mumbai. Data expenditure during each visit collected by team trained medical social workers. The primary outcome variables were total (TC) (OOP), reimbursement. TC...
Abstract Background: Despite several studies, the impact of adding platinum on long-term outcomes in triple-negative breast cancer (TNBC) has not been definitively established. We conducted a single-centre randomized phase III trial to evaluate efficacy and toxicity standard neoadjuvant chemotherapy these patients. Methods: Patients with histopathological diagnosis TNBC without evidence distant metastases who were planned be treated (NACT) experimental or control arms after stratification by...
Abstract Background In India, breast and cervical cancers account for two-fifths of all are predominantly prevalent among women in the reproductive age group. The Government India recommended screening cancer aged 30 years over. This study examines socio-economic regional variations Indian age. Methods A full sample 707,119 15–49 a sub-sample 357,353 30–49 from National Family Health Survey-5 (2019-21) were used analysis. Self-reported ever outcome variables. set risk factors associated with...
The purpose of this study was to identify the prognostic factors affecting outcome in patients with mucoepidermoid carcinoma (MEC) parotid gland.A total 113 MEC who were treated between 1993 and 2002 analyzed.At median follow-up 49 months (range, 1-143 months), disease-free survival (DFS) at 5 10 years 84.6 84.6%, 80.7% 67.3%, 52.5% 35.0% for low-grade, intermediate-grade, high-grade tumors, respectively. Five-year 10-year overall 96.8% low-grade tumors; 94.1% 82.4%, respectively,...
Survival studies may serve as benchmarks to develop cancer-related policies and estimate baseline survival rates in a given patient population.We carried out retrospective audit of cases managed 2009 now report the disease-free (DFS) early breast cancer (EBC) locally advanced (LABC) patients registered at tertiary center India.The study included 2192 with ages ranging from 18 years 94 median 50 years. Of these, 888 (40.5%) were EBCs Stage I II, 833 (38%) LABCs (Stage III), 471 (21.5%) de...
Highlights•Largest data of young breast cancer from India analysing demographics, outcomes and fertility.•Higher proportion YBC with advanced stage aggressive features compared to western data.•Inferior survival in HER-2+ not receiving Trastuzumab, need access life saving drugs all.•Scope improvement collaboration challenges like fertility, pregnancy quality life.AbstractBackgroundYoung (≤40 years) cancers (YBC) are uncommon, inadequately represented trials have unique concerns merit...
Abstract Background The study examined the socio-economic variation of breast cancer treatment and discontinuation due to deaths financial crisis. Methods We used primary data 500 patients with sought at India’s one largest hospital in Mumbai, between June 2019 March 2022. This is registered on Clinical Trial Registry India (CTRI/2019/07/020142). Kaplan–Meier method Cox-hazard regression model were calculate probability discontinuation. Results Of patients, three-fifths under 50 years,...
The purpose of this study was to report quality life newly diagnosed breast cancer patients from India in a large cohort using the EQ-5D-5L instrument.The used longitudinal data 500 and 200 non-cancer subjects registered at our centre, during June 2019 March 2022. EQ-VAS instruments were measure compare utility scores among subjects. Descriptive statistics analyzed Tobit regression model confirm predictors score.The had mean EQ-ED-5L score 0.8703 (SD=0.121), 0.8745 (SD=0.094) 0.8902...
Abstract Objective To estimate the catastrophic health expenditure and distress financing of breast cancer treatment in India. Methods The unit data from a longitudinal survey that followed 500 patients treated at Tata Memorial Centre (TMC), Mumbai June 2019 to March 2022 were used. (CHE) was estimated using households’ capacity pay as selling assets or borrowing loans meet cost treatment. Bivariate logistic regression models used for analysis. Findings CHE 84.2% (95% CI: 80.8,87.9%) 72.4%...
Substantial number of breast cancer (BC) patients undergoing radiation therapy (RT) develop local recurrence over time. During RT therapy, cells can gradually acquire resistance implying adaptive radioresistance. Here we probe the mechanisms underlying this acquired by first establishing radioresistant lines using ZR-75-1 and MCF-7 BC through repeated exposure to sub-lethal fractionated dose 2Gy up 15 fractions. Radioresistance was found be associated with increased stem (CSCs), elevated...
PURPOSE Breast cancer (BC) is the most common malignancy among women in India and globally. Given high survivorship, understanding evolution of health-related quality life (HRQoL) crucial, yet comprehensive longitudinal studies from are lacking. PATIENTS AND METHODS This prospective observational study included 500 patients with BC registered between June 2019 March 2022. HRQoL was assessed at pretreatment, treatment completion, 6-month follow-up using European Organisation for Research...
The use of multicatheter interstitial brachytherapy (MIB) for accelerated partial breast irradiation (APBI) in early cancer (EBC) patients outside the trial setting has increased. Hence, there is a need to critically evaluate implant quality. Moreover, scarcity reports using an open cavity technique. We report dosimetric indices and closed MIB techniques.The parameters 60 EBC treated with (open cavity) who underwent three dimensional, computerized tomography (CT) based planning APBI from...
BackgroundPregnancy associated breast cancer (PABC) is a rare entity and defined as diagnosed during pregnancy or one-year post-partum. There sparse data especially from low middle-income countries (LMIC) merits exploration.MethodsThe study (2013–2020) evaluated demographics, treatment patterns outcomes of PABC.ResultsThere were 104 patients, median age 31 years; 43 (41%) had triple-negative disease, 31(29.8%) hormone-receptor (HR) positive HER2 negative, 14 (13.5%) HER2-positive HR negative...
Synchronous malignancy in both breasts is a rare incidence. The present study aims at dosimetric comparison of conventional bitangential radiotherapy (RT) technique with [field-in-field (FIF)] and rotational [Helical TomoTherapy(®) TomoDirect™ (TD); Accuray Inc., Sunnyvale, CA] intensity-modulated RT for patients synchronous bilateral breast cancer (SBBC).CT data sets 10 SBBC were selected the study. was planned all on sides to whole and/or chest wall using above-mentioned techniques. Six...
Accelerated partial-breast irradiation (APBI) using various approaches is being increasingly employed for selected women with early breast cancer (EBC).To conduct a case-control study comparing disease control, cosmesis, and complications in patients EBC undergoing APBI multicatheter interstitial brachytherapy vs those receiving conventional whole radiotherapy (WBRT).Women fulfilling the American Brachytherapy Society (ABS) criteria were as 'cases' if treated or 'controls' offered WBRT...