A5005104742- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Studies on Chitinases and Chitosanases
- Autophagy in Disease and Therapy
- Biochemical Analysis and Sensing Techniques
- Endoplasmic Reticulum Stress and Disease
- Hearing, Cochlea, Tinnitus, Genetics
- Intracerebral and Subarachnoid Hemorrhage Research
- Botulinum Toxin and Related Neurological Disorders
- DNA Repair Mechanisms
- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Acute Lymphoblastic Leukemia research
- Redox biology and oxidative stress
- Renal and related cancers
- Macrophage Migration Inhibitory Factor
National Institute of Mental Health and Neurosciences
2016-2025
National Institute of Mental Health
2020-2021
All India Institute of Medical Sciences
2002-2005
Directorate of Medicinal and Aromatic Plants Research
2005
Gujarat Cancer Society
1998-1999
Gujarat Cancer & Research Institute
1998-1999
Potential biomarkers to aid diagnosis and therapy need be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed identify the factor(s) which are differentially expressed in cerebrospinal fluid (CSF) of patients with sporadic amyotrophic lateral sclerosis (SALS; ALS-CSF), could associated pathogenesis this disease.Quantitative mass spectrometry ALS-CSF control-CSF (from orthopaedic surgical undergoing spinal...
Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates yeast and mammalian cell lines. induces dramatically enhances autolysosome formation resulting SNCA degradation. Importantly, neuroprotective function as envisaged by immunohistology behavior analyses preclinical...
Non-cell autonomous toxicity is one of the potential mechanisms implicated in etiopathogenesis amyotrophic lateral sclerosis (ALS). However, exact role glial cells ALS pathology yet to be fully understood. In a cellular model recapitulating sporadic ALS, we have studied inflammatory response astroglia following exposure cerebrospinal fluid from patients (ALS-CSF). Various markers including pro-inflammatory and anti-inflammatory cytokines, COX-2, PGE-2, trophic factors, glutamate, nitric...
Both astroglia and microglia show region-specific distribution in CNS often maladapt to age-associated alterations within their niche. Studies on autopsied substantia nigra (SN) of Parkinson's disease (PD) patients experimental models propose gliosis as a trigger for neuronal loss. Epidemiological studies an ethnic bias PD prevalence, since Caucasians are more susceptible than non-whites. Similarly, different mice strains variably sensitive MPTP. We had earlier likened divergent MPTP...
The survival of motor neurons is dependent upon neurotrophic factors both during childhood and adolescence adult life. In disease conditions, such as in patients with amyotrophic lateral sclerosis (ALS), the mRNA levels trophic like brain-derived factor (BDNF), insulin-like growth factor-1 (IGF-1), fibroblast factor-2 (FGF-2), vascular endothelial are downregulated. This was replicated our vivo experimental system following injection cerebral spinal fluid (CSF) sporadic ALS (ALS-CSF)...
Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model.
Microglial cell-associated neuroinflammation is considered as a potential contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis. However, specific role microglia in disease pathogenesis remains be elucidated.We studied activation profiles microglial cultures exposed cerebrospinal fluid from these patients which recapitulates neurodegeneration seen This was done by investigating morphological and functional changes including expression levels prostaglandin E2 (PGE2),...
Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, are lacking. Here, we report and describe the role of Estrogen Related Receptor α (ERRα), new molecular player in keeping flux check by inhibiting autophagosome formation. A screen for small molecule modulators aggrephagy identified ERRα inverse agonist XCT 790, that cleared α-synuclein aggregates an dependent, but MTOR independent manner. 790 modulates formation dependent manner...
BackgroundPlethora of efforts fails to yield a single drug reverse the pathogenesis Parkinson's disease (PD) and related α-synucleopathies.MethodsUsing chemical biology, we identified small molecule inhibitor c-abl kinase, PD180970 that could potentially clear toxic protein aggregates. Genetic, molecular, cell biological immunological assays were performed understand mechanism action. In vivo preclinical model PD was used assess its neuroprotection efficacy.FindingsIn this report, show...
Abstract Postnatal auditory stimulation influences early perceptual learning. Previously we reported morphological effects of prenatal by species‐specific and sitar musical sounds on the chick brainstem nuclei—nucleus magnocellularis nucleus laminaris. At hatching, these two nuclei enriched embryos showed higher neuronal numbers, amongst other changes. There were also increases in synaptophysin syntaxin1 expressions sound groups modulation developmental expression transcription factors c‐Fos...