A5026206744- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Porphyrin and Phthalocyanine Chemistry
- Electrowetting and Microfluidic Technologies
- Photosynthetic Processes and Mechanisms
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Moringa oleifera research and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical Synthesis and Analysis
- Biopolymer Synthesis and Applications
- Respiratory viral infections research
- Parkinson's Disease Mechanisms and Treatments
- Innovation and Socioeconomic Development
- Influenza Virus Research Studies
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- DNA and Biological Computing
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Genomics and Phylogenetic Studies
- Parasitic Diseases Research and Treatment
- Single-cell and spatial transcriptomics
- Lipid Membrane Structure and Behavior
- Lipid metabolism and disorders
Discovery Centre
2023
Walter and Eliza Hall Institute of Medical Research
2023
The University of Melbourne
2023
National Centre for Biological Sciences
2012-2021
Tata Institute of Fundamental Research
2019
Centre for Cellular and Molecular Biology
2017
Max Planck Institute for Brain Research
2006
Institut de Biologie et de Chimie des Protéines
2004
Université Claude Bernard Lyon 1
2004
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance metagenomics data, functional dynamics disease remain elusive. Urolithin A (UroA), a major microbial metabolite derived from polyphenolics berries pomegranate fruits displays anti-inflammatory, anti-oxidative, anti-ageing activities. Here, we show that UroA its potent synthetic analogue (UAS03) significantly enhance barrier function inhibit unwarranted inflammation. We demonstrate...
BackgroundPlethora of efforts fails to yield a single drug reverse the pathogenesis Parkinson's disease (PD) and related α-synucleopathies.MethodsUsing chemical biology, we identified small molecule inhibitor c-abl kinase, PD180970 that could potentially clear toxic protein aggregates. Genetic, molecular, cell biological immunological assays were performed understand mechanism action. In vivo preclinical model PD was used assess its neuroprotection efficacy.FindingsIn this report, show...
Droplet microfluidics has emerged as a critical component of several high-throughput single-cell analysis techniques in biomedical research and diagnostics. Despite significant progress the development individual assays, multiparametric optical sensing droplets their encapsulated contents been challenging. The current approaches, most commonly involving microscopy-based high-speed imaging droplets, are technically complex require expensive instrumentation, limiting widespread adoption. To...
Rapid optical interrogation of flowing cells or particles is a powerful tool in the field biomedical diagnostics. Determination size and composition fast-flowing cells, with diameters range 2-
Abstract Chitin, poly-N Acetyl D-glucosamine, is an abundant polysaccharide produced by fungal cell walls, insect epicuticle and nematodes cuticles. Its immunomodulatory function has curious attributes - paradoxically opposing host responses using different receptors resulting in immunostimulatory or immunosuppressive propertis depending on the size/length of oligomers as well aceytylation levels have been reported literature. Here we demonstrate that Hepta-N-Acetyl Chitoheptaose (7 mer) a...
ABSTRACT Droplet microfluidics has emerged as a critical component of several high-throughput single cell analysis techniques in biomedical research and diagnostics. However, while there been significant progress the individual assays being developed, multi-parametric optical sensing droplets their encapsulated contents remains challenging. The current common approach microscopy based high-speed imaging is technically complex requires expensive instrumentation limiting large-scale adoption....
We describes the design, development and testing of a cost effective miniaturized version flow analyzer. It is designed to detect fluorescence labeled immunocytes in human blood sample. Availing advancements micro fluidics nanolithographic technique, we fabricated PDMS based device with integrated channels for accommodating optical fibers. The lensed fibers serves as waveguides illumination collection laser scattered signals respectively. As cell crosses interrogation point forward scatter,...
Recently, DNA data storage systems have attracted many researchers worldwide. Motivated by the success stories of such systems, in this work we propose a software called BacSoft to clone bacterial plasmid using concept genetic engineering. We consider encoding schemes that it satisfies constraints significant for storage.
Summary HIV-1 causes diverse immunomodulatory responses in the host, including down-regulation of co-stimulatory proteins CD80/86, mediated by protein Nef, blunting T-cell activation. Using a screening cascade biochemical and cell-based assays, we identified potent small molecules representing three chemical scaffolds namely amino pyrimidine, phenoxy acetamide bi-aryl heteroaryl carbamate which target protein-protein interaction interface CD80/86 Nef with sub-micromolar potency. These...
Abstract Nematodes characteristically modulate effector immune responses by synthesizing and releasing both anti-inflammatory as well proinflammatory molecules in infected hosts. Pre-clinical studies suggest that immuno-modulatory synthetic small mimic parasite products could have therapeutic value to ameliorate tissue damage found inflammatory diseases. We report here identification of a glycoprotein from filarial parasite, homologue mammalian Heat Shock Protein 70 with immunostimulatory...