A5069235915- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Luminescence and Fluorescent Materials
- Advancements in Transdermal Drug Delivery
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Proteoglycans and glycosaminoglycans research
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Pomegranate: compositions and health benefits
- SARS-CoV-2 and COVID-19 Research
- Gastrointestinal motility and disorders
- Hydrogels: synthesis, properties, applications
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Gut microbiota and health
- Inhalation and Respiratory Drug Delivery
- Glycosylation and Glycoproteins Research
- Nanocluster Synthesis and Applications
- Antioxidant Activity and Oxidative Stress
- Conducting polymers and applications
- Barrier Structure and Function Studies
- Supramolecular Chemistry and Complexes
Institute for Stem Cell Biology and Regenerative Medicine
2015-2023
Science Foundation Ireland
2023
Novartis (Switzerland)
2022-2023
Saveetha University
2023
University Hospital Galway
2023
Ollscoil na Gaillimhe – University of Galway
2017-2022
National Centre for Biological Sciences
2017
Lovely Professional University
2014-2016
Adesh University
2016
Bangalore University
2015
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance metagenomics data, functional dynamics disease remain elusive. Urolithin A (UroA), a major microbial metabolite derived from polyphenolics berries pomegranate fruits displays anti-inflammatory, anti-oxidative, anti-ageing activities. Here, we show that UroA its potent synthetic analogue (UAS03) significantly enhance barrier function inhibit unwarranted inflammation. We demonstrate...
Abstract This Review is an overview of the unique characteristics cyclodextrin in forming inclusion complex via host–guest noncovalent interactions. The modification advances its application as a pharmaceutical solubilizer, fabrication functional molecular machines such polyrotaxane, polypseudorotaxane, and polycatenanes grafting with different linear, branched chain polymers. stimuli‐based supramolecular assemblies involving key mediator linked triggering responses on payload release...
Delivering drugs directly to the inflamed intestinal sites treat inflammatory bowel disease (IBD), particularly Crohn's and ulcerative colitis, is highly challenging. Recent advances in colitis therapy medications are expanding opportunities for improving local on-site drug availability by minimising associated systemic side-effects. Drug delivery with targeted carrier systems has shown potential increase site-specificity, stability, therapeutic efficacy. Herein, we report development of a...
A novel “<italic>turn-on</italic>” fluorescent chemosensor RDP-1 based on rhodamine tri methoxy benzaldehyde conjugate was synthesized, which showed high selectivity and sensitivity towards recognition of Pb<sup>2+</sup>in aqueous media.
The active stages of intestinal inflammation and the pathogenesis ulcerative colitis are associated with superficial mucosal damage intermittent wounding that leads to epithelial barrier defects increased permeability. standard therapeutic interventions for have focused mainly on maintaining remission levels disease. Nonetheless, such treatment strategies (using anti-inflammatory, immunomodulatory agents) do not address colitis' root cause, especially dysregulated functions. Restoration...
Clinical utility of conventional oral therapies is limited by their inability to deliver therapeutic molecules at the local or targeted site, causing a variety side effects. Transdermal delivery has made significant contribution in management skin diseases with enhanced activities over past two decades. In modern era, various biomimetic and biocompatible polymer–lipid hybrid systems have been used augment transdermal therapeutics such as dermal patches, topical gels, iontophoresis,...
Transdermal drug delivery systems have made significant contributions to the medical community, but yet completely substitute oral or parenteral delivery. Recently, various strategies been used augment transdermal of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds developed evaluated as novel topical...
In the recent days, lipid nanoparticles have been successfully emerged as one of most advanced technology for highly efficient in vivo delivery exogenous mRNA, especially COVID-19 vaccines. For vaccines to be successful or protective, they require mRNA systems. However, developing effective, translatable with better safety against some SARS‐CoV‐2 variants is still a challenge. Lipid (LNPs) are composed four different types lipids including ionizable lipids, helper neutral cholesterol and...
A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil Sima Singh,1,* Niranjan G Kotla,2,* Sonia Tomar,3 Balaji Maddiboyina,4 Thomas J Webster,5,6 Dinesh Sharma,7 Omprakash Sunnapu2 1Department of Pharmaceutical Sciences and Technology, Birla Institute Mesra, Ranchi, Jharkhand, 2Technologies the Advancement Science, Stem Cell Biology Regenerative Medicine, Bangalore, Karnataka, 3Department Pharmaceutics, Ram Gopal College Pharmacy,...
Abstract: A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum often compared with a brick wall, corneocytes surrounded by mortar intercellular lipid lamellae. One best options for successful drug delivery affected area use elastic vesicles (niosomes) which can be transported through channel-like structures. In this study, combination tretinoin (keratolytic agent) benzoyl peroxide (BPO) (a potent...
We have developed a "turn-on" fluorescent probe ARP-1 as colorimetric and chemosensor for adenosine-5'-triphosphate (ATP) through hydrogen bond interactions. The exhibits fluorescence response to ATP with 15-fold intensity enhancement under 10 equiv. of added. experimental results show that the behavior toward is pH independent (pH 4.0-8.0). novel has high specificity towards from other nucleoside polyphosphates such ADP AMP. favorable interaction between triphosphate unit N atoms attributed...
There is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise targeted platform expected to reduce side effects increase therapeutic response at intended site locally. In this study, we report fabrication of hyaluronan (HA) functionalized polymeric hybrid nanoparticulate system (Cur-HA NPs) by using curcumin model...
Abstract: The aim of this study was to develop a novel microbially triggered and animal-sparing dissolution method for testing nanorough polysaccharide-based micron granules colonic drug delivery. In method, probiotic cultures bacteria present in the region were prepared added media compared with performance conventional methodologies (such as rat cecal human fecal media). study, predominant species Bacteroides , Bifidobacterium Lactobacillus Eubacterium Streptococcus ) cultured 12% w/v...
In this work, we report the development of nitrogen-doped carbon dots (NDCDs) as a drug carrier using quercetin (QC) model for anti-cancer delivery application.