Transdermal drug delivery systems have made significant contributions to the medical community, but yet completely substitute oral or parenteral delivery. Recently, various strategies been used augment transdermal of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds developed evaluated as novel topical...

Objective: Paclitaxel (PTX)-loaded polymer (Poly(lactic-co-glycolic acid), PLGA)-based nanoformulation was developed with the objective of formulating cremophor EL-free intended for intravenous use.Significance: The polymeric PTX nanoparticles free from EL will help in eliminating shortcomings existing delivery system as causes serious allergic reactions to subjects after use.Methods and results: Paclitaxel-loaded were formulated by nanoprecipitation method. diminutive (143.2 nm) uniform...

Objective: The objective of the study was to develop interpenetrating polymeric network (IPN) capecitabine (CAP) using natural polymers locust bean gum (LBG) and sodium alginate (NaAlg).Significance: IPN microbeads were optimized by Box–Behnken Design (BBD) provide anticipated particle size with good drug entrapment efficiency. comparative dissolution profile CAP marketed preparation proved an excellent sustained delivery vehicle.Methods: Ionotropic gelation method utilizing metal ion...

Niosomes, non-ionic surfactant-based vesicular systems, have garnered significant attention in recent years for their potential applications drug delivery, gene therapy, and vaccine development. This review article provides a comprehensive overview of current research on niosomes, focusing formulation, characterization, therapeutic applications. Various preparation methods, including thin-film hydration, reverse-phase evaporation, microfluidic techniques, are critically evaluated efficiency...

Argemone mexicana, commonly known as Mexican prickly poppy, is a medicinal plant recognized for its extensive therapeutic applications across various disease conditions. Traditionally employed in folk medicine, A. mexicana utilized to treat ailments such respiratory disorders, skin diseases, and digestive issues. This review highlights the plant's key phytochemical constituents, including alkaloids, flavonoids, saponins, which contribute pharmacological properties. Research has demonstrated...

Objective: The purpose of this research study was to develop, optimize, and characterize dasatinib loaded polyethylene glycol (PEG) stabilized chitosan capped gold nanoparticles (DSB-PEG-Ch-GNPs).Methods: Gold (III) chloride hydrate reduced with the resulting were coated thiol-terminated PEG (DSB). Plackett–Burman design (PBD) followed by Box–Behnken experimental (BBD) employed optimize process parameters. Polynomial equations, contour, 3D response surface plots generated relate factors...

Application of Plackett-Burman factorial design to investigate the effect processing factors in fabrication ionically crosslinked chitosan-tripolyphosphate (CS-TPP) microspheres.Microspheres were screened and optimized provide maximum process yield (PY), encapsulation efficiency (EE), time for 80% drug release (T80%) minimum burst particles size (PS), successful application periodontitis.Processing viz. method preparation (MOP), CS, TPP, crosslinking (CT), agitation (AS), drying technique...

To design, develop, optimize and evaluate sustained-release dasatinib-loaded gold nanoparticles (DSB-GNPs) to treat chronic myeloid leukemia (CML) by using quality design.In this study, we performed risk assessment, optimization, in vitro characterizations, stability drug release studies, cytotoxicity study vivo pharmacokinetic evaluation.DSB-GNPs of desired size, entrapment, smooth, spherical, stable sustained for 48 h were achieved. DSB-GNPs exhibited significantly more percentage growth...

Dendrimers have become a choice, for delivering drugs at the nano level thanks to their structure that allows precise control over size, shape, and surface features. This summary gives an update on progress in using dendrimers drug delivery. To start with it talks about ways are customized delivery needs like modifying surfaces make them more compatible body targeting specific sites. By adding elements respond conditions pH or temperature they can release controlled manner when needed. The...

An attempt has been made to investigate the electrochromic properties of polycarbazole (PCARB) films. Both electrochemical current response and optical transmittance an cell fabricated using PCARB electrochemically deposited on Indium tin oxide (ITO) glass as anode platinum a cathode have experimentally measured. Current transients observed for colouration decolouration films analysed delineate mechanism switching reaction in these semiconducting The times various media range from 87 208 ms...

This research introduces an innovative Sign Language to Speech Conversion Model using Convolutional Neural Networks (CNNs) address communication barriers for the people who are deaf and unable hear properly. The model employs deep learning automatic extraction of spatial patterns from sign language images. A diverse dataset is carefully curated, undergoing Pre-processing improved quality. CNN architecture, designed adaptability, captures local global features, enabling accurate conversion.In...

Ignition delay is the most crucial parameter that influences combustion and engine performance, but it changes with hydrogen as fuel. Sum of physical chemical ignition known total delay, are fuel due to high auto-ignition temperature gaseous nature In this present work, physical, diesel engines working on dual mode has been examined, using additive di-tert butyl peroxide base These mentioned observations were made a 3.50 KW Kirloskar TV1, single cylinder 4 stroke direct at constant speed...

Wire arc additive manufacturing (WAAM) is a popular wire feed technology that creates components through the deposition of material layer-by-layer. WAAM has become promising alternative to conventional machining due its high rate, environmental friendliness, and cost-competitiveness. It used Fabricate complex shaped parts. The variable parameters are current, welding speed, shielding gas, gas flow rate. This research fabricates 316 L stainless steel (WAAM plate) using robot machine....