A5053119028- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Bacterial Genetics and Biotechnology
- Retinoids in leukemia and cellular processes
- Nonmelanoma Skin Cancer Studies
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- Natural Compounds in Disease Treatment
- Urological Disorders and Treatments
- Autism Spectrum Disorder Research
- Barrier Structure and Function Studies
- Genomics, phytochemicals, and oxidative stress
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Ocular Oncology and Treatments
- Cancer Mechanisms and Therapy
- Connexins and lens biology
- Cancer therapeutics and mechanisms
- Tissue Engineering and Regenerative Medicine
- Protein Degradation and Inhibitors
Hamad bin Khalifa University
2021-2024
Hamad Medical Corporation
2019-2024
Khalifa University of Science and Technology
2024
Bridge University
2024
Qatar Foundation
2024
Qatar Airways (Qatar)
2022
Hammersmith Hospital
2016
Imperial College London
2016
Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for majority cases childhood ALL, development resistance to chemotherapy has observed. Thus, new therapeutic are required improve patient's prognosis. Therefore, we investigated anticancer potential curcumin in ALL. We tested panel B-precursor ALL (B-Pre-ALL)...
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for faithful assignment of amino acids to their cognate tRNA. Variants in ARS genes frequently associated with clinically heterogeneous phenotypes humans and follow both autosomal dominant or recessive inheritance patterns many instances. tryptophanyl-tRNA synthetase 1 (WARS1) cause dominantly inherited distal hereditary motor neuropathy Charcot-Marie-Tooth disease. Presently, only one family biallelic WARS1 variants has been described....
Non-melanoma skin cancer (NMSC), encompassing basal and squamous cell carcinoma, is the most prevalent in United States. While surgical removal remains conventional therapy with a 95% 5-year cure rate, there growing interest exploring alternative treatment strategies. In this study, we investigated role of Bortezomib (BTZ), proteasome inhibitor, NMSC. Using two NMSC lines (A431 A388), examined effects BTZ treatment. Our results demonstrated that 48 h led to downregulating Skp2 expression...
Abstract HDAC6 is emerging as an important therapeutic target for cancer. We investigated mechanisms responsible survival of tumor cells treated with a inhibitor. Expression the 20 000 genes examined did not change following treatment in vivo . found that inhibition led to increase AKT activation (P-AKT) vitro , and genetic knockdown phenocopied drug-induced activation. The was observed PTEN null cells; otherwise, PTEN/PIK3CA expression per se predict inhibitor sensitivity. Interestingly,...
Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity vitro. We studied the anticancer of greensporone panel leukemic cell lines. A-mediated inhibition proliferation found to be associated with induction apoptotic death. treatment cells causes inactivation constitutively activated AKT and its downstream targets, including members GSK3 FOXO1, downregulation antiapoptotic genes such as Inhibitor Apoptosis (IAPs) Bcl-2....
The fidelity of translation is ensured by a family proteins named aminoacyl-tRNA synthetases (ARSs), making them crucial for development and survival. More recently, mutations in the tryptophanyl-tRNA synthetase 1 (WARS1) have been linked to various human diseases, from intellectual disability types cancer. To understand function WARS1, we investigated effect WARS-1 depletion during mitotic meiotic cell cycle developing germline Caenorhabditis elegans (C. elegans) demonstrated role genome...
<title>Abstract</title> Thiostrepton, a thiopeptide antibiotic, has been attracting increasing attention for its anti-proliferative and anti-cancer properties in various tested cell culture models. Extensive <italic>in vitro</italic> analysis conducted to understand effect across multiple cancer types lines, with numerous reports indicating that thiostrepton can inhibit proliferation tumor growth induce apoptosis vitro</italic>. On the other hand, vivo</italic> anti-tumor of remains elusive....
Abstract The fidelity of translation is ensured by a family proteins named aminoacyl-tRNA synthetases, making them crucial for development and survival. More recently, mutations in the tryptophanyl-tRNA synthetase ( WARS1 ) have been linked to various human diseases, from intellectual disability types cancer. To understand function WARS1, we investigated effect WARS-1 depletion during mitotic meiotic cell cycle developing germline C. elegans demonstrated role genome integrity. wars-1...