A5101667036- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemoglobin structure and function
- Pleural and Pulmonary Diseases
- Cancer, Hypoxia, and Metabolism
- Myasthenia Gravis and Thymoma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atomic and Subatomic Physics Research
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Erythrocyte Function and Pathophysiology
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Sarcoma Diagnosis and Treatment
Saitama Medical University
2007-2021
Social Insurance Saitama Chuo Hospital
2007-2021
Keio University
2005-2014
New York Institute of Technology
2012
Hiratsuka City Hospital
2011
Kaketsuken (Japan)
2007
Waseda University
1994-2004
Tokyo Medical Center
2000
Kagoshima University
1997
Keio University Hospital
1995
Poly(ethylene glycol) (PEG5000)-conjugated phosphatidylethanolamine was introduced onto the surface of hemoglobin vesicles (HbV); phospholipid encapsulating concentrated Hb (d = 0.257 ± 0.087 μm; P50 32 Torr). The obtained PEG-modified HbV (HbV-PEG) studied for use as a red cell substitute from viewpoint rheology, properties, and hemodynamics. viscosity unmodified suspended in saline ([Hb] 10 g/dL) 2.6 cP (shear rate 358 s-1, 37 °C), less than that human blood (4 cP). However, when 5 g/dL...
Background To evaluate the midterm results of percutaneous cryoablation for medically inoperable stage I non-small cell lung cancer. Methodology/Principal Findings Between January 2004 and June 2010, 160 patients underwent computer tomography guided tumors at our institution. Of these patients, histologically proven cancer with more than one year follow-up, were retrospectively reviewed. All considered to be Charlson comorbidity index 3 or greater. Follow-up was based primarily on computed...
Cutting the intersegmental plane by using a stapler during segmentectomy might interfere with expansion of preserved lung due to visceral pleura caught in staple line, especially large regional segmentectomy, such as left upper division or basal segmentectomy. We compared volume after among methods stapler, sharp dissection, and their combination for cutting ex vivo pig lungs. also examined covering effect polyglycolic acid mesh fibrin glue.To assume clinical practice, segments caudal lobe...
Objective To evaluate the safety and efficacy of cryoablation for metastatic lung tumors from colorectal cancer. Methods The procedures were performed on 24 patients (36–82 years age, with a median age 62; 17 male patients, 7 female patients) 55 in lung, during 30 sessions. procedural safety, local progression free interval, overall survival assessed by follow-up computed tomographic scanning every 3–4 months. Results major complications pneumothorax, 19 sessions (63%), pleural effusion, 21...
Anatomic sublobar resection is being assessed as a substitute to lobectomy for primary lung cancers. However, persistent air leak after anatomic prevalent and increasing surgical morbidity costs. The use of electrocautery popularized recently in resection. We have retrospectively evaluated the safety efficacy intersegmental plane dissection using electrocautery. Between April 2009 September 2010, 47 patients were treated with segmentectomy clinical T1N0M0 non-small cell was dissected alone...
Malignant pleural mesothelioma is known to be widely resistant therapy and new treatment strategies are needed. Curcumin, which has a long history as dietary spice suppress the growth of multiple cancer lines, but effects on cells not well defined. In present study we examined curcumin ACC‐MESO‐1, human derived cell line. We found that dose‐dependently reduced viability did induce apoptosis. Curcumin administration increased LC3B‐II/LC3B‐I expression, induced formation autophagosomes...
Objectives To evaluate the oxygen transporting capabilities of hemoglobin vesicles by studying physiologic responses to exchange transfusion with in anesthetized rats. Exchange transfusions phosphate buffered saline, containing methemoglobin (and therefore, deprived capabilities), and washed rat red blood cells were used as controls. Design Prospective, randomized, controlled trial. Setting Department Surgery, School Medicine, Keio University. Subjects Twenty-seven male Wistar Interventions...
Human serum albumin (HSA) incorporating synthetic hemes, the tetrakis(o-pivalamido)phenylporphinatoiron(II) derivative (FeP), is an artificial hemoprotein (HSA-FeP) which able to reversibly bind and release dioxygen under physiological conditions (in aqueous media, pH 7.4, 37 °C) like hemoglobin myoglobin. Physiological responses exchange transfusion with HSA-FeP solution [[HSA], 5 g/dL; FeP/HSA, 4 (mol/mol)] into rats after hemodilution hemorrhage (Hct, about 10%) has been evaluated. The...
Objective: There is little experimental evidence to show how much positive airway pressure fibrin sealants can actually withstand, and in particular, this effect changes over time. In the present study, we experimentally evaluated sealing of glue against alveolar air leakage up 48 h after application. Methods: Beagles were used (n=48). Under thoracotomy, approximately 5×10 mm defects (2 depth) made on lung surface. Fibrin applied defect three ways. rubbing spray method, fibrinogen was...
ADAM28 (a disintegrin and metalloproteinase 28) is over-expressed in non-small-cell lung cancer (NSCLC) with correlation to cell proliferation, tumor size lymph node metastasis. The present study was aimed develop an enzyme-linked immunosorbent assay (ELISA) system for diagnosis monitoring of NSCLC. Our ELISA specifically measured ADAM28, showing negligible cross-reactivity other metalloproteinases. level the NSCLC tissue remarkably 36.9-fold higher than that non-neoplastic (p < 0.001)....
Compensatory lung growth has been well described as a phenomenon in many animal models, but still little is known about the nature, extent, and modulation of such growth. We hypothesized that compensatory may at least part recapitulate developmental growth, factors to be important during normal development, thyroid transcription factor 1 (TTF-1), reactivated growth.To investigate role TTF-1 correlation with morphological changes growth.Sequential expression morphology were examined residual...
Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation nuclear kappa B (NFkappaB)-related pathways association with reduction ikappaB level may be one such potential mechanisms. It is known that curcumin inhibits inducible activation NFkappaB at least part by sustaining expression level. Therefore, we evaluated effects coadministration on...
Encapsulation of hemoglobin within a liposome is one the strategies in development artificial oxygen carriers. It maintains transporting properties and, at same time, eliminates side effects cell free hemoglobin. Hemoglobin vesicles (HbV) are type encapsulated They have particle size approximately 250 nm, concentration 10 g/ dl, and affinity, P50, regulated to 32 Torr. In this study authors examined capability HbV vivo, by performing exchange transfusions rats. Exchange transfusion (90%...