A5003529714- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Colorectal Cancer Treatments and Studies
- bioluminescence and chemiluminescence research
- Protist diversity and phylogeny
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Vanadium and Halogenation Chemistry
- Transgenic Plants and Applications
- Supercapacitor Materials and Fabrication
- Aldose Reductase and Taurine
- Metal complexes synthesis and properties
- Neuroendocrine Tumor Research Advances
- Synthesis and Characterization of Heterocyclic Compounds
- Free Radicals and Antioxidants
- Photosynthetic Processes and Mechanisms
- Advanced Fiber Optic Sensors
- Advanced Fiber Laser Technologies
- RNA modifications and cancer
- Metal-Catalyzed Oxygenation Mechanisms
Tohoku University
2015-2025
Yamanashi Prefectural Central Hospital
2024-2025
Fukushima College
2019-2025
Kōchi University
2022-2025
Toho University
2014-2024
Jikei University School of Medicine
2006-2024
Tohoku University Hospital
2012-2024
National Institute of Technology
2023-2024
Sapporo Kosei General Hospital
2024
University of Electro-Communications
1998-2024
The Keap1-Nrf2 system plays a central role in cytoprotection against electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major sensor cysteine residues for detecting these stresses, it has not been technically feasible to evaluate the functionality Cys273 or Cys288, since mutants that harbor substitutions maintain ability repress Nrf2 accumulation do exist. To overcome this problem, we systematically introduced amino acid into Cys273/Cys288 finally identified...
The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, identity of reactive oxygen species sensor within Keap1 remains poorly understood. Here, we show that mutant lacking 11 cysteine residues retains ability to target Nrf2 for degradation, but it is unable respond cysteine-reactive inducers. Of mutated residues, find 4 (Cys226/613/622/624) are important sensing hydrogen peroxide. Our analyses multiple mice lines, complemented by MEFs expressing series mutants,...
We elucidated the metabolism of methylglyoxal (MG) in chloroplasts higher plants. Spinach showed MG-dependent NADPH oxidation because aldo-keto reductase (AKR) activity. K(m) for MG and V(max) AKR activity were 6.5 mm 3.3 µmol (mg Chl)(-1) h(-1) , respectively. Addition to illuminated induced photochemical quenching (Qp) Chl fluorescence, indicating that stimulated photosynthetic electron transport (PET). Furthermore, enhanced light-dependent uptake O(2) into chloroplasts. After illumination...
A secondary epidermal growth factor receptor ( EGFR ) mutation, the substitution of threonine 790 with methionine (T790M), leads to acquired resistance reversible ‐tyrosine kinase inhibitors ‐ TKI s). non‐invasive method for detecting T790M mutation would be desirable direct patient treatment strategy. Plasma DNA samples were obtained after discontinuation gefitinib or erlotinib in 75 patients non‐small cell lung cancer NSCLC ). was amplified using SABER (single allele base extension...
Numerous small molecules (termed inducers), many of which are electrophiles, upregulate cytoprotective responses and inhibit pro-inflammatory pathways by activating nuclear factor-erythroid 2 p45-related factor (NRF2). Key to NRF2 activation is the ability chemically modifying critical sensor cysteines in main negative regulator NRF2, Kelch-like ECH-associated protein 1 (KEAP1), C151, C273 C288 best characterized. This study aimed establish requirement for these cysteine sensor(s) biological...
β-Stereoselective mannosylation using donors bearing the 2,6-lactone moiety is described. In general, glycosylation a nucleophilic substitution reaction between an alcoholic nucleophile and sugar containing leaving group at anomeric position. Owing to stereoelectronic effects, tends proceed via SN1 mechanism afford α-glycosides. We found that introduction of bridge can circumvent competing reaction, affording β-glycosides with stereoinversion SN2(-like) mechanisms. Glycosyl...
BackgroundThis multicenter phase 2 trial evaluated the safety and efficacy of osimertinib platinum-based chemotherapy (OPP) in patients with previously untreated EGFR-mutated advanced non-squamous non-small cell lung cancer (NSCLC).Patients methodsPatients received 80 mg once daily (QD), either cisplatin 75 mg/m2 (arm A) or carboplatin (area under curve [AUC] = 5; arm B), plus pemetrexed 500 for four cycles maintenance therapy QD every 3 weeks. The primary end-points were objective response...
Objective Several studies have suggested that an elevated neutrophil–lymphocyte ratio (NLR) is associated with a poorer prognosis in patients pancreatic cancer (PC). The correlations between the NLR and immunohistochemical (IHC) analysis regard to of PC remain be elucidated. By using IHC findings, we determined value as prognostic factor PC. Material methods We collected clinico-pathological data 28 consecutive who underwent surgical resection for January 2008 December 2012 at Jikei...
Microwave bubble plasma in water is a novel applicable to the processing of materials liquid. An electromagnetic simulation slot excitation microwaves reveals that electric field at antenna significantly influenced by size existing front antenna. To improve power efficiency and stability, control plate installed adjacent antenna, effect which on enhancement confirmed simulation. Furthermore, three antennas are newly developed. According these modifications microwave system, dramatic increase...
Abstract Companion diagnostic (CDx) tests play important roles in identifying oncogenic driver genes and tailoring effective molecularly targeted therapies for lung cancer patients. In Japan, the Oncomine Dx target test (ODxTT) AmoyDx pan PCR panel (AmoyDx) are prominent CDx only one of these is covered by domestic insurance system. However, cover different regions apply technologies (ODxTT amplicon-based next-generation sequencing multiplex PCR-based assay), which may lead to missing...
Teratogenic potential of ethylenethiourea (ETU) was investigated in SLC-ICR mice after its reaction with sodium nitrite. ETU given orally doses 400 mg/kg on various days pregnancy combination 200 NaNO2 at varied intervals. When to females immediately their treatment day 6 or 8 pregnancy, fetal survival significantly decreased. Various types malformations were observed the living fetuses from mothers treated 6, 8, 10 but not 12. The teratogenicity disappeared when 2 h ETU.
In Arabidopsis thaliana, the aldo-keto reductase (AKR) family includes four enzymes (The AKR4C subfamily: AKR4C8, AKR4C9, AKR4C10, and AKR4C11). AKR4C8 AKR4C9 might detoxify sugar-derived reactive carbonyls (RCs). We analyzed AKR4C10 AKR4C11, compared enzymatic functions of enzymes. Modeling protein structures based on known structure found an (α/β)8-barrel motif in all Loop (A, B, C) which determine substrate specificity, differed among four. Both AKR4C11 reduced methylglyoxal. triose...
Lung cancer is the deadliest disease globally, with more than 120,000 diagnosed cases and 75,000 deaths annually in Japan. Several treatment options for advanced lung are available, discovery of biomarkers will be useful personalized medicine. Using metabolome analysis, we aimed to identify diagnosis response by examining changes metabolites associated progression. Plasma samples from patients recurrent or metastatic non-small cell carcinomas at Tohoku University Hospital between 2019 2024...
Abstract Background The association of maternal hyperglycemia with childhood developmental delay has been examined; however, only 2 studies used blood glucose level as a continuous variable an exposure. A present study aimed to investigate the influence fasting plasma (mFPG) in early gestation on children. Methods This cohort included 1541 mother–child pairs who participated Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. mFPG before 24 gestational weeks was obtained...
The formation of resting cysts is a strategy for survival in unfavorable environments by single cell organisms such as protists. Here, we show that Colpoda have high salinity tolerance and investigate the changes gene expression underpin this effect. can tolerate saline conditions up to 3.5 % NaCl. A comparative transcriptome analysis vegetative cells showed relative levels genes associated with membrane function increased cysts. These suggest reconstruction plasma tolerance. cyst forms...
The emergence of immune checkpoint inhibitors (ICIs) has revolutionized standard therapies for non-small cell lung cancer (NSCLC) [...]