A5070380363- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cerebral Palsy and Movement Disorders
- Management of metastatic bone disease
- Musculoskeletal synovial abnormalities and treatments
- Cardiac tumors and thrombi
- Nutrition and Health in Aging
- Cancer Diagnosis and Treatment
- Children's Physical and Motor Development
- Musculoskeletal pain and rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Spine and Intervertebral Disc Pathology
- Balance, Gait, and Falls Prevention
- Infant Development and Preterm Care
- Frailty in Older Adults
- Scoliosis diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Obesity, Physical Activity, Diet
- Spinal Fractures and Fixation Techniques
- Tumors and Oncological Cases
- Orthopaedic implants and arthroplasty
- Soft tissue tumors and treatment
- Cancer survivorship and care
Nagoya University
2016-2025
Clinical Orthopaedics and Related Research
2018
Committee on Publication Ethics
2018
Aichi Cancer Center
2008-2017
John Wiley & Sons (United States)
2016
Bipar
2013
Nagoya Memorial Hospital
1997-2011
Ministry of Education, Culture, Sports, Science and Technology
2011
In-Q-Tel
2008
Shizuoka Cancer Center
2005
The objective of this study was to identify the MRI criteria that best differentiate malignant peripheral nerve sheath tumors from benign neurofibromas.We retrospectively analyzed MR images obtained for 41 histologically diagnosed cases tumor and 20 neurofibroma had been treated at four tertiary institutions. Twenty patients with 14 neurofibromas developed disease in association neurofibromatosis 1. were evaluated regard size, signal intensity, heterogeneity T1- T2-weighted images,...
Between 1992 and 1999, we treated 350 patients with skeletal metastases. A multivariable analysis of the was conducted using Cox proportional hazards model. We identified five significant prognostic factors for survival, namely, site primary lesion, performance status (Eastern Cooperative Oncology Group 3 or 4), presence visceral cerebral metastases, any previous chemotherapy, multiple The score each factor derived from corresponding estimated regression coefficients (natural logarithm...
The prognosis of patients with bone metastasis from lung cancer has not been well documented. We assessed the survival rates after and prognostic factors in 118 metastases cancer. cumulative were 59.9% at 6 months, 31.6% 1 year, 11.3% 2 years. mean was 9.7 months (median, 7.2 months; range, 0.1-74.5 months). A favorable more likely women adenocarcinoma, solitary metastasis, no to appendicular bone, pathologic fractures, performance status or less, use systemic chemotherapy, an epithelial...
Because the efficacy and safety of pazopanib in Japanese patients with soft tissue sarcoma (STS) had not been evaluated previously a large-scale cohort, authors investigated 156 relapsed STS. This was retrospective study based on collection real-life, postmarketing surveillance data.Patients received objective treating local recurrence (n = 20), metastasis 104), both 32). The patient median age 53.8 years. primary this to clarify for STS.The treatment duration 28.7 weeks, average dose...
In the present study, we evaluated safety and effectiveness of SYT-SSX-derived peptide vaccines in patients with advanced synovial sarcoma. A 9-mer spanning SYT-SSX fusion region (B peptide) its HLA-A*2402 anchor substitute (K9I) were synthesized. Protocols A1 A2, alone administered subcutaneously six times at 14-day intervals. The B was used Protocol A1, whereas K9I A2. B1 B2, mixed incomplete Freund's adjuvant then addition, interferon-α injected on same day again 3 days after vaccination....
Regular physical activity is an important component of health children and has been associated with increasing skeletal muscle mass strength. Children low levels may experience problems, such as loss mass, later in life. Thus, it be valuable to identify declining function who do not perform the recommended amount activity. Therefore, we aimed evaluate relationship between performed for ≥60 min per day ≥5 days week index young children. In total, 340 typically developing aged 6–12 years (175...
ObjectiveEribulin, a microtubule dynamics inhibitor, is approved for the treatment of patients with breast cancer and soft tissue sarcoma. We investigated efficacy safety eribulin in Japanese
BACKGROUND When skeletal metastasis is the presenting problem and primary site occult, there a need to identify as soon possible. However, search for tumor often time-consuming difficult. The purpose of this study was analyze efficacy particular diagnostic approaches devise an efficient optimal strategy. METHODS Among 213 patients with treated between 1990 1996 were 64 in whom lesions first manifestation malignancy. authors retrospectively analyzed both final diagnosis process by which it...
Abstract We aimed to develop gait standards for parameters in school-aged Japanese children and assess age-related differences patterns parameters. Children aged 6–12 years (n = 424) were recruited from two elementary schools. An instrumented three-dimensional analysis system was used record each child's kinematics, kinetics, spatiotemporal Participants subdivided into three age groups (Group A, 6–8 years; Group B, 9–10 C, 11–12 years). LMS Chartmaker, version 2.54, create a developmental...
Abstract Objective This study aimed to determine whether there are associations between laughter, disease activity, frailty, and depression in rheumatoid arthritis (RA) patients. Methods A total of 240 patients were included this prospective cohort on frailty RA March 2021 June 2022. Patients divided into the following four groups according frequency laughter: “almost every day,” “1–5 days per week,” “1–3 month,” “never or almost never.” Patient characteristics compared among by analysis...
Abstract Background Few studies have described the characteristics and prognostic factors of osteosarcoma patients aged over 60 years. Methods The Japanese Musculoskeletal Oncology Group (JMOG) carried out a retrospective review age years with osteosarcoma. Results Only 12 had secondary osteosarcoma, none associated Paget's disease. primary disease sites were extremities in 63% trunk 33%. overall survival was 42.8% disease‐free 40.8% at 5 high grade group. An univariate analysis indicated...
Trabectedin is reported to be particularly effective against translocation-related sarcoma. Recently, a randomized phase 2 study in patients with sarcomas unresponsive or intolerable standard chemotherapy was conducted, which showed clinical benefit of trabectedin compared best supportive care (BSC). Extraskeletal myxoid chondrosarcoma (EMCS) and Mesenchymal (MCS) are very rare malignant soft tissue sarcomas, associated translocations resulting fusion genes. In addition, the previous vivo...
Unicameral bone cyst (UBC) is the most common benign lytic lesion seen in children. The aim of this study to investigate clinical factors affecting pathological fracture and healing UBC. We retrospectively reviewed 155 UBC patients who consulted Nagoya musculoskeletal oncology group hospitals Japan. Sixty had at presentation. Of 141 with follow-up periods exceeding 6 months, 77 were followed conservatively 64 treated by surgery. risk was significantly higher humerus than other bones. In...
Trabectedin is a novel anticancer agent used to treat soft tissue sarcoma (STS). This phase I study of trabectedin was performed determine the recommended dose for II studies in Japanese patients with STS.Patients who had STS refractory to, or could not tolerate, anthracycline-based chemotherapy were enrolled. The starting 0.9 mg/m(2), given as 24-h continuous infusion every 21 days. escalated 1.2 mg/m(2) and then 1.5 using "3 + 3" cohort expansion design. Plasma samples collected...
This analysis of the Japanese subpopulation PALETTE Phase III, randomized, placebo-controlled study investigated efficacy and safety pazopanib in patients with metastatic soft tissue sarcoma after failure standard chemotherapy. Patients were randomly assigned a 2:1 ratio to receive either 800 mg once daily or placebo, no subsequent cross-over. Primary endpoint was progression-free survival. Secondary endpoints included overall survival response rate. Efficacy by intent-to-treat. Safety also...
Several reports have shown peritumoral edema accompanying primary bone tumors demonstrated by magnetic resonance imaging (MRI). However, the mechanism of this inflammatory reaction is still unclear. The authors postulated that was caused some chemical mediators including prostanoids, because several investigators observed types synthesize prostanoids. Therefore, compared MRI findings and tumor prostaglandin (PG) levels.The subjects were 29 patients with or tumor-like conditions:...