A5070736750- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Treatment and Pharmacology
- Ion channel regulation and function
- Breast Cancer Treatment Studies
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Frailty in Older Adults
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Radiopharmaceutical Chemistry and Applications
- Advanced Breast Cancer Therapies
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Neural Networks and Reservoir Computing
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Cancer and Skin Lesions
- Receptor Mechanisms and Signaling
- Cancer Research and Treatments
- Neural Networks and Applications
- Neuroendocrine Tumor Research Advances
Kamiichi General Hospital
2006-2025
Tokyo Rinkai Hospital
2020-2022
National Hospital Organization
2017-2019
Dokkyo Medical University
2019
Kohnan Hospital
2019
Niigata University
2004-2019
Tokyo Medical University
2017-2019
Yodogawa Christian Hospital
2019
International University of Health and Welfare
2018-2019
Yokohama City University
2018
Background— Experimental studies suggest that the interval between peak and end of T wave (Tpe) in transmural ECGs reflects dispersion repolarization (TDR), which is amplified by β-adrenergic stimulation LQT1 model. In 82 patients with genetically identified long-QT syndrome (LQTS) 33 control subjects, we examined T-wave morphology various parameters for 12-lead including corrected QT (QTc; QT/R-R 1/2 ) Tpe (Tpec; Tpe/R-R before during exercise stress tests. Methods Results— Under baseline...
Novel Mutation in Hypokalemia‐Induced LQTS. Congenital long QT syndrome (LQTS) is caused by mutations at least five genes coding for cardiac potassium or sodium channels that regulate the duration of ventricular action potentials. Acquired LQTS often associated with drugs metabolic abnormalities. A 47‐year‐old woman who presented marked prolongation (QTc = 620 msec 1/2 ) and repeated episodes torsades de pointes hypokalemia (2.6 mEq/L) was screened using polymerase chain...
Ion Channel Polymorphism and Cardiac Arrhythmia. Introduction: Congenital long QT syndrome (LQTS) is a genetically heterogeneous arrhythmogenic disorder caused by mutations in at least five different genes encoding cardiac ion channels. It was suggested recently that common polymorphisms of LQTS‐associated might modify arrhythmia susceptibility potential gene carriers. Methods Results: We examined the known LQTS 95 patients with definitive or suspected LQTS. Exon‐specific polymerase chain...
e12601 Background: Based on the Norton-Simon model, dose-dense (dd) chemotherapy with shortened intervals between administrations has been adopted in perioperative for breast cancer. However, safety and efficacy of dd neoadjuvant settings have not thoroughly investigated. Methods: The aim this study is to evaluate versus standard regimen chemotherapy. patients HER2-negative cancer who underwent (NAC) anthracycline-taxane were continuously identified 2014 2023. These divided into a triple...
Purpose Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption by inhibiting the mevalonate pathway. Its benefit for prevention of skeletal complications due to metastases has been established. However, antitumor efficacy ZOL, although suggested multiple preclinical clinical studies, not yet clinically proven. We performed present randomized Phase 2 trial investigate effect ZOL with chemotherapy (CT). Methods Asian...
Abstract BACKGROUND: The effectiveness of additional chemotherapy in preventing intrahepatic distant tumor recurrence hepatocellular carcinoma (HCC) has not been fully established. authors compared the efficacy 2 platinum‐based chemotherapeutic agents combination with radical local treatment for (IDR). METHODS: Seventy‐eight patients stage I/II HCC aged 45 to 85 years underwent transcatheter arterial chemoembolization and/or radiofrequency ablation after they received hepatic infusion (HAI)...
Hepatitis C virus (HCV) associated HCC shows a high rate of recurrence even after curative treatment. Outcomes pegylated interferon PEGIFN a-2b/ribavirin (RBV) therapy for HCV-associated have yet to be elucidated. We investigated therapeutic response and hepatic functional reserve improvement in patients receiving PEG-IFN a-2b/RBV treatment.We survival rate, metachronous 54 with initial Stage I/II HCC; 29 were administered preparation treatment (Secondary IFN group) 25 not (Non-secondary...
The liver is involved in the synthesis of serum proteins, regulation metabolism and maintenance homeostasis provides a variety opportunities for gene therapy. enriched vasculature blood circulation, fenestrated endothelium, abundant receptors on plasma membranes cells, effective transcription translation machineries hepatocytes are some unique features that have been explored delivery, functional analysis, genetic sequences liver. Both viral non-viral methods developed delivery liver-based...
Hepatocellular carcinoma (HCC) is frequently complicated with cirrhosis, and it not unusual for treatment options to be limited as a result of pancytopenia due hypersplenism. Partial splenic embolization (PSE) has been performed thrombocytopenia resulting from We studied the efficacy in terms hepatic functional reserve safety patients who underwent concurrent transcatheter arterial chemoembolization (TACE) PSE HCC.The study population consisted 101 HCC thrombocytopenia. Fifty-three were...
Background: Postoperative delirium (POD) is one of the most common postoperative complications in gastrointestinal surgery patients. POD has been reported to affect long-term activities daily living, cognitive function decline, and mortality. Previous studies have indicated that preoperative physical activity (PA) predicted patients with other diseases, but we not found any reports cancer. In this retrospective study, investigated relationship between PA cancer Methods: was diagnosed based...
Cell swelling enhances a slowly activating delayed rectifier K+ current (IKs) in cardiac cells. This investigation was undertaken to determine which of the two structural units reconstituting IKs channel, KCNQ1 (KvLQT1) and KCNE1 (minK/IsK), plays key role cell swelling-induced enhancement dissect possible involvement tyrosine phosphorylation therein. transiently expressed alone or together with heterologous mammalian line. Two distinct whole-cell membrane currents were separately observed...
The Child-Pugh classification system is the most widely used for assessing hepatic functional reserve in HCC treatment. In system, serum albumin levels are to accurately assess status of protein metabolism and nutrition. To date, a lack attention has been given amino acid metabolism. present study, we investigated whether branched-chain acids tyrosine ratio (BTR) as an indicator can serve both prognostic factor early predictive recurrence.We conducted cohort study 50 patients with stage I/II...
Whole-cell patch-clamp techniques were employed to examine the effects of bepridil, a Ca2+ channel blocker with Vaughan Williams class III action, on slow component cardiac delayed rectifier K+ current (IKs), which was reconstituted in HEK293 cells by transfecting KCNQ1 and KCNE1. Micromolar bepridil inhibited tail currents carried KCNQ1/KCNE1 channels concentration-dependent manner (IC50 = 5.3 ± 0.7 μM at −40 mV from 1000 milliseconds test pulse). When effect drug examined short pulse...
Aim Disease characteristics of primary biliary cholangitis have changed recently. However, detailed studies on the subject been limited. Therefore, we aimed to clarify disease patients with recent using cohort from Niigata University and 21 affiliated hospitals. Methods Overall, 508 were enrolled in this study 1982 2016, divided into three cohorts according their year diagnosis: ≤1999, 2000–2009 ≥2010. We compared differences clinical characteristics, response ursodeoxycholic acid prognosis....
Background: Lumbar supports are used in the management of low back pain (LBP). Although various types lumbar available, insufficient evidence exists regarding their effectiveness. The aim this study was to investigate effect two support on postural change and muscle fatigue a prospective longitudinal study.Methods: A total 144 subjects (9 men 135 women) with LBP were enrolled study. Subjects divided into 2 groups: conventional lumbosacral (LS) group wear-type (SW) group. They filled...
Purpose The present study aimed to investigate the association between preoperative physical activity (PA) and postoperative functional recovery in gastrointestinal cancer patients.Materials methods In this prospective study, we included 101 patients who underwent colorectal or gastric surgery. Primary outcome was 6-minute walk distance (6MWD) decline ratio ((postoperative 6MWD value – value)/preoperative × 100 (%)), which determined as recovery. Patients were divided into two groups...