A5086787911- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Virus-based gene therapy research
- Plant Virus Research Studies
- Plant Molecular Biology Research
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Chromosomal and Genetic Variations
- Cancer Research and Treatments
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Genetics and Reproduction
- Stress Responses and Cortisol
- Sepsis Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Calcium signaling and nucleotide metabolism
- Hemodynamic Monitoring and Therapy
- Neural dynamics and brain function
- Glycosylation and Glycoproteins Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Microtubule and mitosis dynamics
- Sirtuins and Resveratrol in Medicine
National Center For Child Health and Development
2023
Hyogo University
2022-2023
RIKEN Center for Brain Science
2007-2023
Hyogo Medical University
2018-2022
Hokkaido University
2011-2022
Uji Hospital
2021
Jichi Medical University
2016-2020
Jichi Medical University Saitama Medical Center
2016-2020
Asahi Kasei (Germany)
2016
Nara Medical University
2012-2015
Abstract Transposable elements (TEs), or transposons, play an important role in adaptation. TE insertion can affect host gene function and provides a mechanism for rapid increases genetic diversity, particularly because many TEs respond to environmental stress. In the current study, we show that transposition of heat-activated retrotransposon, ONSEN , generated mutation abscisic acid (ABA) responsive gene, resulting ABA-insensitive phenotype Arabidopsis suggesting stress tolerance. Our...
Environmental stress influences genetic and epigenetic regulation in plant genomes. We previously reported that heat activated a copia-like retrotransposon named ONSEN. To investigate the sensitivity transgenerational activation of ONSEN, we analyzed response by temperature shift multiple treatments. ONSEN was at 37°C, newly inserted transcriptionally active mobile to next generation subjected stress, indicating is independent positional effects on chromosome. Reciprocal crosses with...
Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in brain. In adult mammals, CSPGs form specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites certain types neurons. PNNs restrict synaptic plasticity regulate closure critical periods. Although previous studies have examined starting period PNN formation, focusing on primary sensory cortices, there no systematic at whole brain level. Here, we formation male mice...
Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed clarify effect using propensity score analyses. Data from 3,195 consecutive adult patients admitted 42 intensive care units severe sepsis treatment were retrospectively analyzed; 1,784 diagnosed with (n = 715, group; n 1,069,...
Transposable elements (TEs) are key that facilitate genome evolution of the host organism. A number studies have assessed functions TEs, which change gene expression in genome. Activation TEs is controlled by epigenetic modifications such as DNA methylation and histone modifications. Several recent reported can also be activated biotic or abiotic stress some plants. We focused on a Ty1/copia retrotransposon, ONSEN, heat Arabidopsis. found transcriptional activation ONSEN was regulated an...
Early‐life stress has long‐lasting effects on neuroendocrine and behaviour in adulthood. Maternal separation ( MS ) is used as a model of early‐life daily repeated RMS for 3 h during the first two postnatal weeks widely rodent studies. However, it not fully understood whether animals desensitise/habituate to stress. In present study, we investigated acute/single time SMS plasma corticosterone level c‐ F os expression brain mice at different ages. Mice were subjected to: (i) from day PND 1 14...
Severe sepsis is a major concern in the intensive care unit (ICU), although there very little epidemiological information regarding severe Japan. This study evaluated 3195 patients with 42 ICUs throughout The had mean age of 70 ± 15 years and Acute Physiology Chronic Health Evaluation II score 23 9. estimated survival rates at 28 90 days after ICU admission were 73.6 56.3 %, respectively.
Visual motion cues are one of the most important factors for eliciting animal behaviour, including predator-prey interactions in aquatic environments. To understand elements that cause such selective predation we used a virtual plankton system where behaviour response to computer-generated prey was analysed. First, performed analysis zooplankton (Daphnia magna) extract mathematical functions biologically relevant motions prey. Next, models were programmed on computer and presented medaka...
The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment patients with sepsis in Japan, but its efficacy the reduction mortality has not been evaluated. We investigated whether IVIgG associated clinically important outcomes including intensive care unit (ICU) and in-hospital mortality.This a post-hoc subgroup analysis data from retrospective cohort study, Japan Septic Disseminated...
A transposition of a heat-activated retrotransposon named ONSEN required compromise small RNA-mediated epigenetic regulation that includes RNA-directed DNA methylation (RdDM) machinery after heat treatment. In the current study, we analyzed transcriptional and transpositional activation to better understand underlying molecular mechanism involved in maintenance and/or induction transposon plant tissue culture. We found heat-primed during culture independently RdDM mutation. The transcripts...
Abstract OBJECTIVES Outcomes of planned and unplanned (rescue) double arterial cannulation (DAC) in surgery for acute type A aortic dissection were investigated retrospectively. METHODS The study involved 805 patients who divided into 4 groups according to the strategy: single femoral artery (n = 338), axillary 256), left ventricular apex 52) or ascending aorta 5) (total, n 57), DAC 154). Patients underwent between 132) rescue 22) usage. Characteristics outcomes compared groups. Both...
Gene therapy using vectors has attracted attention in recent years for the treatment of cancers caused by gene mutations. Besides, new treatments are imperative lung cancer, including non-small cell cancer (NSCLC) and malignant pleural mesothelioma (MPM), due to its high mortality. We developed a minimally invasive orally inhalable tumor suppressor drug (SFD-p16 SFD-p53) with non-viral combining genes an inhalant powder that can deliver active ingredients directly lung. used NSCLC (A549...
Cancer stem cells (CSCs) are major contributors to the malignant transformation of because their capacity for self-renewal. Aldehyde dehydrogenase1A1 (ALDH1A1) and CD133 promising candidate CSC markers in non-small cell lung cancer (NSCLC). Furthermore, TP53 is frequently mutated cancer, loss its function associated with characteristics. However, relationship between CSCs mutant p53 adenocarcinoma not well-established. We examined expression ALDH1A1, CD133, patients conducted a...
An increase in nicotinamide adenine dinucleotide (NAD+) levels alleviates age-related disease progression and promotes healthy life expectancy. Several studies have demonstrated that NAD+ can be efficiently replenished via mononucleotide (NMN) intake; additionally, the safety of its oral ingestion has been confirmed recent clinical trials. However, efficacy intravenous NMN administration humans remain unclear. Therefore, we verified 10 volunteers. Intravenous did not affect...
The vasopressin (AVP) and oxytocin (OXT) magnocellular neurons in the hypothalamic supraoptic (SON) paraventricular nuclei (PVN) display reversible structural plasticity of glial cells under different conditions neuropeptide secretion. In present study, we investigated expression two immunoglobulin superfamily (IgSF) proteins, Kilon OBCAM, by using monoclonal antibodies. Anti-Kilon antibody reacted specifically with bacterially expressed recombinant but not similarly anti-OBCAM recognized...