A5010295108- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Microstructure and mechanical properties
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Metallurgy and Material Forming
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Cancer, Hypoxia, and Metabolism
- Thermal Regulation in Medicine
- Metal Forming Simulation Techniques
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Hemoglobinopathies and Related Disorders
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Neural dynamics and brain function
- Superconducting Materials and Applications
- Extracellular vesicles in disease
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Inflammatory Bowel Disease
Asahikawa Medical University
2016-2025
Kanazawa University Hospital
2024
National Center for Global Health and Medicine
2024
Kobe University Hospital
2023-2024
Shibaura Institute of Technology
2024
Osaka University
2006-2024
Tokyo Medical and Dental University
2024
Sapporo Science Center
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2024
ProQuest (United States)
2024
AimsThe Speckle Tracking and Resynchronization (STAR) study used a prospective multi-centre design to test the hypothesis that speckle-tracking echocardiography can predict response cardiac resynchronization therapy (CRT).
Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved not yet been identified. Here, we show culture supernatant of Lactobacillus casei ATCC334 has a strong tumour-suppressive effect on colon cells. Using mass spectrometry, identify ferrichrome as molecule produced by L. ATCC334. The is greater than cisplatin 5-fluorouracil, less an non-cancerous intestinal cells either those agents. A transcriptome analysis reveals...
Abstract Hypoxia-inducible factor 1 (HIF-1) is involved in tumor progression/metastasis and activated various cancers. Here we show that HIF-1α, which plays a major role HIF-1 activation, overexpressed preneoplastic hepatocytic lesions from very early stage during hepatocarcinogenesis mice man. Transcriptional targets of HIF-1, such as vascular endothelial growth factor, glut-1, c-met, insulin-like II (IGF-II), were also mouse lesions. Oxygen tension within the was not different normal...
In this study we evaluated the role of hyaluronan (HA) in reactive adipogenesis, a local expansion preadipocytes that provides host defense by release antimicrobial peptides. We observed HA accumulated during maturation adipocytes vitro and was associated with increased expression preadipocyte factor 1, zinc finger protein 423, early B cell 1. Although is normally abundant extracellular matrix, further increase staining occurred mice at sites adipogenesis following injury colon dextran...
Pancreatic cancer is associated with a poor prognosis due to challenges in early detection, severe progression of the primary tumor, metastatic lesions, and resistance antitumor agents. However, previous studies have indicated relationship between microbiome pancreatic outcomes. Our study demonstrated that ferrichrome derived from Lactobacillus casei, probiotic bacteria, exhibited tumor‑suppressive effects colorectal gastric cancer, suppressive were stronger than conventional agents, such as...
Abstract Epithelial‐mesenchymal transition (EMT) describes a process occurring during development and oncogenesis by which epithelial cells obtain fibroblast‐like properties show reduced cell adhesion increased motility. In this report, we demonstrated typical EMT in human mammary MCF10A small interfering (si)RNA gelsolin‐knockdown cells. was characterized fibroblastic morphology, loss of contact inhibition focus formation monolayer growth, enhanced motility invasiveness vitro , actin...
The control system for stand-alone doubly fed induction generator (DFIG) is commonly based on the "sensorless" direct voltage control. This paper adopts and employs negative-sequence compensation through rotor-side converter to support asymmetric "unbalanced" loads. demonstrates limitation of conventional obtain slip angle, consequent full range To overcome these limitations, this proposes a new estimator angle rotor current in synchronous reference frame. proposed requires one DFIG...
Colchicine binds to intracellular tubulin and prevents mitosis. is also used as an anti-inflammatory drug. Meanwhile, excess administration of medication or accidental ingestion colchicine-containing plants can cause acute colchicine poisoning, which initially results in gastrointestinal effects that may be followed by multiorgan dysfunction. However, the mechanism poisoning remains unclear, there are no standard therapeutic strategies. We focused on intestinal barrier function attempted...
Abstract Background Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with development progression of colorectal cancer via these pathways. We identified Lactobacillus casei -derived ferrichrome as a mediator bacterial anti-tumor effect cells upregulation DDIT3. In this study, we investigated effects on precancerous conditions sporadic well...
We report the generation of picosecond pulsed light at a 266 nm wavelength with an average power 53 W. developed 1064 laser source 261 W, repetition rate 1 MHz, and pulse duration 14 ps, using gain-switched DFB diode as seed 914 laser-diode-pumped Nd-doped YVO4 amplifier. achieved stable W from frequency quadrupling LBO CLBO crystals. The amplified pumped Nd:YVO4 amplifier are highest ever reported, to best our knowledge.
Hypothermia is a condition in which body temperature falls below 35 °C, resulting from exposure to low environmental temperatures or underlying medical conditions. Postmortem examinations have revealed increased levels of fatty acids blood and lipid droplet formation renal tubules during hypothermia. However, the causes implications these findings are unclear. This study aimed analyze biological significance phenomena through lipidomics transcriptomics analyses specimens emergency...
Humans and animals use visual cues such as brightness color boundaries to identify objects navigate through environments. However, even when these are not available, we can effortlessly perform tasks by using second-order contrast variation (envelope) of patterns on surfaces. Previously, numerous psychophysical studies examined properties binocular depth processing based the contrast-envelope suggested existence a stereo system that uses cues. its physiological substrate has been identified...
Multiple sclerosis (MS) has been suggested to be an autoimmune demyelinating disease of the central nervous system (CNS), whose primary target is either myelin itself, or myelin-forming cells, oligodendrocytes. Although axonal damage occurs in MS, it regarded as a secondary event damage. Here, lesion develops from (outside) axons (inside) "Outside-In model". The Outside-In model supported by for experimental (allergic) encephalomyelitis (EAE). However, recently, (1) EAE-like also shown...
Ferrichrome is known to be a siderophore, but it was recently identified as tumor-suppressive molecule derived from Lactobacillus casei ATCC334 (L. casei). In the present study, we investigated effects of ferrichrome in gastric cancer cells. Cell lines and xenograft models treated with demonstrated growth suppression. The expression levels cleaved poly (adenosine diphosphate-ribose) polymerase, caspase-9 were increased by treatment. Although almost completely diminished iron chelation,...
Group 2 innate lymphoid cells (ILC2s) are a critical source of type cytokines in allergic inflammation. Although ILC2s recognized as cell population the inflammation, regulatory mechanism(s) less well understood. Here, we show that Regnase-1, an immune RNAse degrades inflammatory mRNAs, negatively regulates ILC2 function and IκB kinase (IKK) complex–mediated Regnase-1 degradation is essential for IL-33– IL-25–induced activation. from Regnase-1AA/AA mice expressing S435A/S439A mutant...
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's (CD), is an intractable intestinal inflammation associated with the disruption of mucosa. We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved barrier function by upregulation cell adhesion relieved inflammation, thereby exerting a curing effect on in vitro, vivo, investigator-initiated clinical study UC. However, how poly P improves mucosal defects induced has not...
Abstract STAT3 activation is involved in development and progression of hepatocellular carcinoma (HCC). We investigated during hepatocarcinogenesis induced by neonatal diethylnitrosamine (DEN) treatment mice. Nuclear accumulation phosphorylation were detected altered hepatocyte foci the early stages as well adenomas HCCs late stages. Although total levels same between hepatic lesions normal livers, S727‐phosphorylated was enhanced HCCs, whereas Y705‐phosphorylated mainly HCCs. In mouse HCC...
There is considerable evidence that intestinal microbiota are involved in the development of metabolic syndromes and, consequently, with non-alcoholic fatty liver disease (NAFLD). Toll-like receptors (TLRs) essential for recognition microbiota. However, induction mechanism TLR signals through gut-liver axis triggering steatohepatitis (NASH) or NAFLD remains unclear. In this study, we investigated role palmitic acid (PA) a pro-inflammatory state NAFLD.Non-alcoholic was induced mice fed high...
Abstract RNA regulation mediating RNA-binding proteins (RBPs) have been shown to be related the maintenance of homeostasis as well cancer progression. However, tumor-associated functions detailed mechanisms underlying anti-tumor effects most RBPs yet explored. We herein report that phosphorylated heterogeneous ribonucleoprotein (hnRNP) A0 promotes mitosis through RAS-associated protein 3 GTPase-activating catalytic subunit 1 (RAB3GAP1)-Zeste white 10 interactor (ZWINT1) cascade. The...