A5085365946- Cancer Research and Treatments
- Thermal Regulation in Medicine
- Cardiovascular Effects of Exercise
- Probiotics and Fermented Foods
- Burn Injury Management and Outcomes
- Extracellular vesicles in disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Oral and gingival health research
- Cardiac Arrest and Resuscitation
- Molecular Biology Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Restraint-Related Deaths
- Fibroblast Growth Factor Research
- Gout, Hyperuricemia, Uric Acid
- Environmental DNA in Biodiversity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Microbial Inactivation Methods
- Liver Diseases and Immunity
- Microbial Metabolism and Applications
- Dietary Effects on Health
- Veterinary medicine and infectious diseases
Tokai University
2022-2025
Asahikawa Medical University
2015-2022
Asahikawa University
2021-2022
Hitachi General Hospital
2017
Colchicine binds to intracellular tubulin and prevents mitosis. is also used as an anti-inflammatory drug. Meanwhile, excess administration of medication or accidental ingestion colchicine-containing plants can cause acute colchicine poisoning, which initially results in gastrointestinal effects that may be followed by multiorgan dysfunction. However, the mechanism poisoning remains unclear, there are no standard therapeutic strategies. We focused on intestinal barrier function attempted...
Hypothermia is a condition in which body temperature falls below 35 °C, resulting from exposure to low environmental temperatures or underlying medical conditions. Postmortem examinations have revealed increased levels of fatty acids blood and lipid droplet formation renal tubules during hypothermia. However, the causes implications these findings are unclear. This study aimed analyze biological significance phenomena through lipidomics transcriptomics analyses specimens emergency...
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's (CD), is an intractable intestinal inflammation associated with the disruption of mucosa. We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved barrier function by upregulation cell adhesion relieved inflammation, thereby exerting a curing effect on in vitro, vivo, investigator-initiated clinical study UC. However, how poly P improves mucosal defects induced has not...
Abstract Intake of probiotics or fermented food produced by some probiotic bacteria is believed to exert anti-tumor functions in various cancers, including pancreatic cancer, because several studies have demonstrated the effects vitro and vivo animal carcinogenesis models. However, mechanisms underlying anticancer on cancer not been clarified. In this study, we assessed against cells. Among known bacteria, Aspergillus oryzae exhibited a strong tumor suppression effect. The culture...
Cardiac hypertrophy, which develops in middle-aged and older individuals as a consequence of hypertension obesity, is an established risk factor for sudden cardiac death (SCD). However, it sometimes difficult to differentiate SCD with acquired hypertrophy (SCH) from compensated (CCH), at autopsy. We aimed elucidate the proteomic alteration SCH, can be guideline future postmortem diagnosis.Cardiac tissues were sampled SCH group consisted ischemic heart failure, hypertensive aortic stenosis....
Hypothermia, either therapeutically induced or accidental (ie, an involuntary decrease in core body temperature to <35°C), results hemostatic disorders. However, it remains unclear whether hypothermia enhances inhibits coagulation, especially severe hypothermia. The present study evaluated the thrombocytic and changes hypothermic mice.C57Bl/6 mice were placed at ambient of -20°C under general anesthesia. When rectal decreased 15°C, 10 immediately euthanized, while another rewarmed, kept...
Abstract Background Several microorganisms inhabit the mammalian gastrointestinal tract and are associated with pathogenesis of various diseases, including cancer. Recent studies have indicated that several probiotics produce antitumor molecules inhibit host tumor progression. We demonstrated heptelidic acid (HA), a sesquiterpene lactone derived from probiotic Aspergillus oryzae , exerts effects against pancreatic cancer in vitro vivo. In this study, HA extraintestinal melanoma were assessed...
Age prediction based on methylation analysis has been reported in many populations, with 10 ng or more of DNA usually required for each determination. In this study, we designed thermostable locked nucleic acid (LNA) primers by replacing a small number bases standard LNAs. We evaluated these primer sets single-base extension using 10, 5, 2 that would be less than template used testing, and determined sensitivity accuracy. analyzed EDARADD, SST, KLF14 genes, targeting one CpG site gene....
Hepatocellular carcinoma (HCC) activates platelets through the action of adjacent sinusoidal cells. Activated bind to tumor-associated endothelial cells and release growth factors that promote tumor progression. We hypothesized encapsulated with inhibitors would function as drug carriers for therapy. propose a therapeutic strategy HCC using autologous encapsulating multiple tyrosine kinase in rat chemically induced model. Sorafenib or lenvatinib was isolated from tumor-bearing rats vitro....
The organized functioning of the anisotropic myocardial layers-including inner longitudinal, middle circular, and outer longitudinal layers-is essential for stable systemic circulation. However, proteomic profile each layer has not been studied yet. Here, we aimed to elucidate layer-specific human cardiac tissue using microscopic sampling.
Coronavirus disease 2019 (COVID-19) is an emerging respiratory infectious caused by severe acute syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been reported to lead cardiac injury, but previous research indicated that the mechanism different from of other viruses and remains poorly understood. Herein, we describe a case COVID-19-associated sudden death, in healthy 47-year-old man after developing diffuse necrosis. Two days before patient developed general malaise without symptoms. The...
Drowning is a comprehensive and exclusive diagnosis at autopsy. Autopsy findings such as pleural effusion waterlogged lungs contribute to the diagnosis. Herein, we aim reveal practical usefulness postmortem changes of maxillary sinus fluid volume diagnose drowning.
An attempt to use combination therapy with anti-tumor necrosis factor α (TNFα) antibodies and tacrolimus (TAC) has been tried induce remission in ulcerative colitis (UC). However, the optimal dose of TAC anti-TNFα (TAC + therapy) remains unclear. We examined efficacy various doses a mouse model. Dextran sulfate sodium induced model mice were divided into an antibody monotherapy group groups that received therapy. The nuclear expression activated T-cells, cytoplasmic 1 (NFATc1) nuclei mRNA...