A5022964718- CAR-T cell therapy research
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Mycotoxins in Agriculture and Food
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Toxin Mechanisms and Immunotoxins
- Cell Adhesion Molecules Research
- Bacillus and Francisella bacterial research
- Adenosine and Purinergic Signaling
- Immunotoxicology and immune responses
- Peptidase Inhibition and Analysis
- Skin and Cellular Biology Research
- Cancer Immunotherapy and Biomarkers
- Carcinogens and Genotoxicity Assessment
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Glycosylation and Glycoproteins Research
- Hair Growth and Disorders
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
Chugai Pharma (United States)
2018
Mitsubishi Tanabe Pharma Corporation
2009-2011
Mitsubishi Group (Japan)
2009
Laboratoire d’immunologie intégrative du cancer
2009
Michigan State University
2009
Tanabe Research Laboratories
2006
The University of Tokyo
1997-2003
Teikoku Seiyaku (Japan)
2003
Tokyo University of Agriculture
1997-1999
Nihon University
1996
Abstract Small-cell lung cancer (SCLC) is an aggressive for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers are promising therapeutic alternatives ICI-resistant tumors, but not all patients with SCLC responsive. Herein, to integrate CD137 costimulatory function into a engager format and thereby augment efficacy, we generated CD3/CD137 dual-specific Fab engineered DLL3-targeted trispecific antibody (DLL3 trispecific). The was competitively...
Deoxynivalenol (DON), a trichothecene mycotoxin found in grains and cereal–based foods worldwide, impairs weight gain experimental animals but the underlying mechanisms remain undetermined. Oral exposure to DON induces rapid transient upregulation of proinflammatory cytokine expression mouse. The latter are known induce several suppressors signaling (SOCS), some which impair growth hormone (GH) signaling. We hypothesized that oral will SOCS Real-time PCR bead array revealed gavage with...
We examined T-2 toxin-induced lesions in the bone marrow and splenic red pulp as many 48 hr after oral inoculation with 10 mg/kg body weight of toxin female ICR:CD-1 mice. Histopathologically, showed a significant hypocellularity. In marrow, number myelocytes significantly decreased due to loss immature granulocytes, erythroblasts, lymphocytes. The nuclei remaining cells showing pyknosis or karyorrhexis were positively stained by TdT-mediated dUTP nick end labeling (TUNEL) method, these...
Female ICR:CD-1 mice orally treated with 10 mg/kg b.w. of T-2 toxin were killed at 1, 3, 6, 9, 12, 24 and 48 hr after treatment (HAT) subjected to examination the process development toxin-induced apoptosis in thymus spleen. The early ultrastructural changes lymphocytes characterized by shrinkage cell body condensation nuclear chromatin detected 3HAT thymus. number apoptotic observed situ detection method for fragmented DNA increased drastically from 9 HAT while it began increase 12 ladder...
Abstract Identifying a strategy with strong efficacy against non-inflamed tumours is vital in cancer immune therapy. ERY974 humanized IgG4 bispecific T cell-redirecting antibody that recognizes glypican-3 and CD3. Here we examine the combination effect of chemotherapy (paclitaxel, cisplatin, capecitabine) treatment xenograft model. monotherapy shows minor antitumour on NCI-H446 xenografted tumours, as infiltration ERY974-redirected cells limited to tumour-stromal boundary. However, therapy...
Feline panleukopenia virus (FPLV) was shown to induce apoptosis feline lymphoid cells and reduce the expression of interleukin-2 receptor alpha on cells. FPLV-induced might be a key element in pathophysiology atrophy tissues associated with caused by FPLV.
Satratoxin G (SG), a macrocyclic trichothecene produced by Stachybotrys chartarum, induces apoptosis in cultured neuronal cells as well nasal olfactory sensory neurons (OSN) the nose and brain of mice exposed intranasally to this toxin. The purposes study were (1) develop facile method for production purification both SG its putative biosynthetic precursor, roridin L2 (RL2), from S. chartarum cultures (2) compare their relative neurotoxicity vitro vivo. 29-58-17 was Fernbach flasks on rice...
Acute lesions in the dorsal skin topically applied with T-2 toxin (10 microliters of 0.5 mg/ml-solution to 1 cm2) were examined Wistar-derived hypotrichotic WBN/ILA-Ht rats up 24 hours after treatment (24HAT). In epidermis, depression basal cell proliferating activity was detected at 3HAT by immunostaining for nuclear antigen (PCNA), and percentage PCNA-positive cells decreased thereafter. At 12HAT, addition intracytoplasmic edema spinous cells, acidophilic degeneration characterized...
Ovarian cancer remains a formidable challenge in oncology, necessitating innovative therapeutic approaches. Claudin-6 (CLDN6), member of the tight junction molecule CLDN family, exhibits negligible expression healthy tissues but displays aberrant upregulation various malignancies, including ovarian cancer. Although several modalities targeting CLDN6 are currently under investigation, there is still need for more potent options. While T-cell engagers (TCEs) hold substantial promise as...
T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. This paper reviews the reported data about development and/or mechanisms toxin-induced apoptosis in hematopoietic, lymphoid and gastrointestinal tissues, dorsal skin fetal tissues mice rats. Apoptosis occurs earlier hematopoietic than moreover there difference among lymphocyte populations susceptibility to toxin. C-fos plays an important role early phase through mobilization [Ca2+]i PKC-dependent...
T-2 toxin (3 mg/kg b.w.) was orally inoculated to pregnant mice at 11 days of gestation examine the effect on developing embryos. At 24 hours after toxin-inoculation, moderate pyknosis or karyorrhexis generally observed in some layers central nervous system, caudal sclerotomic segment, region tongue pharyngeal- laryngeal-mesenchyma, trachea and facial mesenchyma. These pyknotic karyorrhectic nuclei were strongly stained by modified TUNEL method widely used for situ detection apoptotic also...
Lymphocytic apoptosis in Peyer's patches the small intestine of mice orally inoculated with T-2 toxin (10mg/kg b.w.) were examined for up to 48 hours after inoculation (HAI). The number apoptotic lymphocytes observed by situ detection method fragmented DNA increased significantly from 6HAI and reached a plateau at 24HAI. Ultrastructurally, characterized shrinkage cell body condensation nuclear chromatin and/or margination condensed along membrane 6HAI. Some nuclei into pieces, these pieces...
T-2 toxin is a kind of trichothecene mycotoxin produced by species the genus Fusarium, and it attacks tissues containing large number actively dividing cells such as lymphoid hematopoietic tissues. The development apoptosis changes in mRNA expressions apoptosis-related cell-surface antigen (Fas) genes (p53, bcl-2, c-myc, c-fos) were investigated thymus up to 9 hours after oral inoculation (HAI) with 10 mg/kg body weight female ICR: CD-1 mice. TUNEL-positive lymphocytes clearly increased...
Esophageal carcinoma was observed in an eight-year-old, castrated male, Japanese domestic cat. Histologically, this neoplasm consisted of two different growth patterns, squamous cell and adenocarcinoma. The results immunohistochemical examination supported the fact that kinds neoplastic cells have characteristics. tumor was, therefore, diagnosed as adenosquamous carcinoma. tumors cat are very rare and, if any, neither adenocarcinoma nor has been reported up to present.
Pregnant Wistar rats were injected i.p. with 5-azacytidine (5AzC) at 11 day of gestation. Brain cell apoptosis determined morphologically or by TUNEL method was observed in the fetuses 3 hrs after injection. Eight to 100% dead 1 to7 Injection doses less than 5 mg/kg 5AzC killed only a few fetuses, though neuronal detected most living fetuses. All when their dams 9 10 gestation, whereas alive 12. The present study revealed that specifically induce rat stage logarithmic growth.