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Sotaro Naoi

ORCID: 0000-0002-3545-1894
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A5080321414
Research Areas
  • Lung Cancer Research Studies
  • CAR-T cell therapy research
  • Cancer therapeutics and mechanisms
  • Immunotherapy and Immune Responses
  • Protein purification and stability
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
 Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

Abstract Small-cell lung cancer (SCLC) is an aggressive for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers are promising therapeutic alternatives ICI-resistant tumors, but not all patients with SCLC responsive. Herein, to integrate CD137 costimulatory function into a engager format and thereby augment efficacy, we generated CD3/CD137 dual-specific Fab engineered DLL3-targeted trispecific antibody (DLL3 trispecific). The was competitively...

10.1158/2326-6066.cir-23-0638 article EN Cancer Immunology Research 2024-04-01
 Figure S2 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S2. Overview of the generation CD3/CD137 dual-specific Fab</p>

10.1158/2326-6066.25964679 preprint EN cc-by 2024-06-04
 Data from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<div>Abstract<p>Small-cell lung cancer (SCLC) is an aggressive for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers are promising therapeutic alternatives ICI-resistant tumors, but not all patients with SCLC responsive. Herein, to integrate CD137 costimulatory function into a engager format and thereby augment efficacy, we generated CD3/CD137 dual-specific Fab engineered DLL3-targeted trispecific antibody (DLL3 trispecific). The...

10.1158/2326-6066.c.7267968 preprint EN 2024-06-04
 Figure S4 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S4. DLL3 trispecific induces multiple cytokine production and DLL3- dependent cytotoxicity</p>

10.1158/2326-6066.25964670.v1 preprint EN cc-by 2024-06-04
 Figure S6 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S6. Cross-reactivity of DLL3 trispecific.</p>

10.1158/2326-6066.25964664.v1 preprint EN cc-by 2024-06-04
 Figure S9 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S9. The use of dexamethasone and tocilizumab does not limit the antitumor efficacy DLL3 trispecific.</p>

10.1158/2326-6066.25964655 preprint EN cc-by 2024-06-04
 Figure S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S1. The composition of the antibodies</p>

10.1158/2326-6066.25964682.v1 preprint EN cc-by 2024-06-04
 Figure S8 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S8. DLL3 trispecific induced activation of tumor-infiltrating T cells.</p>

10.1158/2326-6066.25964658.v1 preprint EN cc-by 2024-06-04
 Figure S3 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S3. Binding of DLL3 trispecific to FcγRs, C1q, and FcRn. (</p>

10.1158/2326-6066.25964673.v1 preprint EN cc-by 2024-06-04
 Figure S7 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S7. DLL3 expression of SCLC xenograft models.</p>

10.1158/2326-6066.25964661.v1 preprint EN cc-by 2024-06-04
 Table S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>pharmacokinetic parameters of DLL3 trispecific in cynomolgus monkeys</p>

10.1158/2326-6066.25964649 preprint EN cc-by 2024-06-04
 Figure S4 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S4. DLL3 trispecific induces multiple cytokine production and DLL3- dependent cytotoxicity</p>

10.1158/2326-6066.25964670 preprint EN cc-by 2024-06-04
 Figure S8 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S8. DLL3 trispecific induced activation of tumor-infiltrating T cells.</p>

10.1158/2326-6066.25964658 preprint EN cc-by 2024-06-04
 Figure S2 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S2. Overview of the generation CD3/CD137 dual-specific Fab</p>

10.1158/2326-6066.25964679.v1 preprint EN cc-by 2024-06-04
 Figure S6 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S6. Cross-reactivity of DLL3 trispecific.</p>

10.1158/2326-6066.25964664 preprint EN cc-by 2024-06-04
 Supplementary Methods from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Methods</p>

10.1158/2326-6066.25964652.v1 preprint EN cc-by 2024-06-04
 Table S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>pharmacokinetic parameters of DLL3 trispecific in cynomolgus monkeys</p>

10.1158/2326-6066.25964649.v1 preprint EN cc-by 2024-06-04
 Figure S7 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S7. DLL3 expression of SCLC xenograft models.</p>

10.1158/2326-6066.25964661 preprint EN cc-by 2024-06-04
 Figure S5 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S5. DLL3 trispecific induces cytotoxicity against non-SCLC tumors.</p>

10.1158/2326-6066.25964667 preprint EN cc-by 2024-06-04
 Supplementary Methods from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Methods</p>

10.1158/2326-6066.25964652 preprint EN cc-by 2024-06-04
 Figure S5 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S5. DLL3 trispecific induces cytotoxicity against non-SCLC tumors.</p>

10.1158/2326-6066.25964667.v1 preprint EN cc-by 2024-06-04
 Figure S9 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S9. The use of dexamethasone and tocilizumab does not limit the antitumor efficacy DLL3 trispecific.</p>

10.1158/2326-6066.25964655.v1 preprint EN cc-by 2024-06-04
 Data from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<div>Abstract<p>Small-cell lung cancer (SCLC) is an aggressive for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers are promising therapeutic alternatives ICI-resistant tumors, but not all patients with SCLC responsive. Herein, to integrate CD137 costimulatory function into a engager format and thereby augment efficacy, we generated CD3/CD137 dual-specific Fab engineered DLL3-targeted trispecific antibody (DLL3 trispecific). The...

10.1158/2326-6066.c.7267968.v1 preprint EN 2024-06-04
 Figure S3 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S3. Binding of DLL3 trispecific to FcγRs, C1q, and FcRn. (</p>

10.1158/2326-6066.25964673 preprint EN cc-by 2024-06-04
 Figure S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
OPENALEX - Publications 
Hirofumi Mikami Shu Feng Yutaka Matsuda Shinya Ishii Sotaro Naoi and 31 more Yumiko Azuma Hiroaki Nagano Kentaro Asanuma Yoko Kayukawa Toshiaki Tsunenari Shogo Kamikawaji Ryutaro Iwabuchi Junko Shinozuka Masaki Yamazaki Haruka Kuroi Samantha Shu Wen Ho Siok Wan Gan Priyanka Chichili Chai Ling Pang Chiew Ying Yeo Shun Shimizu Naoka Hironiwa Yasuko Kinoshita Yuichiro Shimizu Akihisa Sakamoto Masaru Muraoka Noriyuki Takahashi Tatsuya Kawa Hirotake Shiraiwa Futa Mimoto Kenji Kashima Mika Kamata‐Sakurai Shumpei Ishikawa Hiroyuki Aburatani Takehisa Kitazawa Tomoyuki Igawa

<p>Supplementary Figure S1. The composition of the antibodies</p>

10.1158/2326-6066.25964682 preprint EN cc-by 2024-06-04
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