A5020240574- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Nuclear materials and radiation effects
- Gastric Cancer Management and Outcomes
- Magnetic and transport properties of perovskites and related materials
- Advanced Condensed Matter Physics
- interferon and immune responses
- Immunotherapy and Immune Responses
- Particle accelerators and beam dynamics
- Plasma Diagnostics and Applications
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Rare-earth and actinide compounds
- Mast cells and histamine
- Neurogenesis and neuroplasticity mechanisms
- Electronic and Structural Properties of Oxides
- Neonatal and fetal brain pathology
- Ion-surface interactions and analysis
- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
University of Miyazaki
2025
University of Miyazaki Hospital
2025
Tohoku University
1986-2019
Chiba Prefectural University of Health Sciences
2017
Kyushu University
2002-2014
Ragon Institute of MGH, MIT and Harvard
2012
Osaka University
1974-2007
Takara (Japan)
2007
Pain Management Institute
2006
Tokyo Medical and Dental University
2006
To determine whether maximum bite force (MBF), an objective measure of oral function, is associated with development frailty in community-dwelling older adults. This prospective cohort study included Japanese adults aged 75 years at baseline (n = 322). Baseline MBF was measured using electronic recording device (Occlusal Force-Meter GM10). Follow-up examinations, including physical fitness and anthropometric evaluation structured questionnaires, were administered annually over a 5-year...
Two experimental systems were used to investigate the origin of precursor cells which differentiate into tissue mast in vivo. (a) Increase cell number was examined skin, stomach, cecum, and mesentery genetically cell-depleted WBB6F1 (WB X C57BL/6)-W/WV mice after injection various hematolymphoid congenic +/+ mice. (b) Appearance with giant granules studied irradiated C57BL/6-+/+ lymphoid C57BL/6-bgJ/bgJ (beige, Chediak-Higashi syndrome) Concentrations precursors thymus, lymph node Peyer's...
We analyze recently-measured total reaction cross sections for 24-38Mg isotopes incident on 12C targets at 240 MeV/nucleon by using the folding model and antisymmetrized molecular dynamics(AMD). The well reproduces measured sections, when projectile densities are evaluated deformed Woods-Saxon (def-WS) with AMD deformation. Matter radii of then deduced from fine-tuning parameters def-WS model. matter largely enhanced nuclear Fully-microscopic calculations no free parameter reproduce 24-36Mg,...
Background: Preterm infants often have unstable vital signs and prolonged hospital stays that can hinder parent–infant bonding, especially under COVID-19 restrictions. This study aimed to evaluate whether listening songs recorded by parents was effective in stabilizing the condition of premature infants. Methods: randomized controlled conducted at University Miyazaki Hospital from October 2022 March 2024 during pandemic period. The participants were preterm born less than 33 weeks gestation...
Summary Interleukin (IL)-17 is a newly identified T cell-derived cytokine that can regulate the functions of variety cell types. In this study, we investigated effects IL-17 and interferon (IFN)-γ on chemokine secretion in human fetal intestinal epithelial cells. IL-8 monocyte chemoattractant protein (MCP)-1 by line, intestine-407, was evaluated ELISA Northern blot. The expression receptor (R) analysed binding assay using [125I]-labelled IL-17. activation nuclear factor-κB (NF-κB), NF-IL6...
Abstract Overcoming resistance to immune checkpoint inhibitors is an important issue in patients with non‐small‐cell lung cancer (NSCLC). Transcriptome analysis shows that adenocarcinoma can be divided into three molecular subtypes: terminal respiratory unit (TRU), proximal proliferative (PP), and inflammatory (PI), squamous cell carcinoma (LUSQ) four. However, the immunological characteristics of these subtypes are not fully understood. In this study, we investigated landscape NSCLC tissues...
The presence or absence of lymph-node metastasis is the single most important factor in determining strategy for treating superficial carcinoma esophagus. In this study, ultrasound (US) and endoscopic ultrasonography (EUS) were used diagnosis metastases, accuracy limitations these methods assessed.Prospectively, 37 patients with esophageal cancer studied by US EUS before surgery, results compared histological findings. Twelve had histologically confirmed metastases. Ultrasonographic images...
Abstract Background The poor quality of oral health care for people with intellectual disability (ID) has been recognized, and the strong fears about dental treatment suggested as a major reason disturbances visits to dentists by such patients. Intravenous sedation is useful method relieving anxiety fear patients treatment, frequently essential ID undergoing treatment. However, decision regarding dose sedative required be administered an adequate level difficult because effect cannot...
Background: Interleukin (IL)-17 is a newly identified T-cell-derived cytokine that can regulate the functions of variety cell types. In this study, we investigated effects CD4 + cytokines on chemokine secretion in human pancreatic periacinar myofibroblasts. Methods: The IL-8 and monocyte chemoattractant protein (MCP)-1 was evaluated by ELISA Northern blot. expression IL-17 receptor (R) analyzed blot binding assay using 125 I-labeled IL-17. activation nuclear factor- s B (NF- B) assessed...
Bile acids have been shown to exhibit varying degrees of cytotoxicity, depending on their hydrophobic-hydrophilic balance. We recently reported the strong cytotoxicity hyodeoxycholic acid (HDCA), and aim present study is investigate mechanisms underlying HDCA.The intestinal cell lines IEC-6 Caco-2 cells were used. The cytotoxicities various bile evaluated using MTS assay; cytolytic effects measured LDH release assay. induction apoptosis was determined by specific figure changes in cellular...