A5051309626- Drug-Induced Hepatotoxicity and Protection
- PARP inhibition in cancer therapy
- Pharmacogenetics and Drug Metabolism
- Bipolar Disorder and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes Management and Research
- Pediatric health and respiratory diseases
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Diabetes Treatment and Management
- Genetic and Environmental Crop Studies
- Electrolyte and hormonal disorders
- Electroconvulsive Therapy Studies
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Immunotoxicology and immune responses
- Cardiac Fibrosis and Remodeling
- Cerebral Venous Sinus Thrombosis
- Chronic Kidney Disease and Diabetes
- Cardiac Ischemia and Reperfusion
- Frailty in Older Adults
- Erythrocyte Function and Pathophysiology
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
Nihon University
2021-2025
St. Marianna University School of Medicine
2017-2021
Niigata University
2014-2017
Yamaguchi University
2016
Kindai University
2016
Kyorin University
2016
Tottori University
2016
Fukuoka Dental College
2016
Nagoya University
2016
Osaka Medical and Pharmaceutical University
2016
To determine whether maximum bite force (MBF), an objective measure of oral function, is associated with development frailty in community-dwelling older adults. This prospective cohort study included Japanese adults aged 75 years at baseline (n = 322). Baseline MBF was measured using electronic recording device (Occlusal Force-Meter GM10). Follow-up examinations, including physical fitness and anthropometric evaluation structured questionnaires, were administered annually over a 5-year...
<h3>Objective:</h3> To investigate the clinical and epidemiologic features of pediatric acquired demyelinating syndromes (ADS) CNS in Japan. <h3>Methods:</h3> We conducted a nationwide survey collected data on children with ADS aged 15 years or younger, who visited hospitals between 2005 2007. <h3>Results:</h3> Among 977 enrolled, 723 (74.0%) responded to our inquiries reported total 439 patients as follows: 244 acute disseminated encephalomyelitis (ADEM), 117 multiple sclerosis (MS), 14...
ABSTRACT The dose–response relationship between metformin and change in hemoglobin A1c (HbA1c) shows a maximum at 1500–2000 mg/day patients with type 2 diabetes (T2D) the U.S. In Japan, there is little evidence on HbA1c‐lowering effect of high‐dose because maintenance doses were raised 2010. aim this study was to investigate whether saturation for Japanese T2D patients. Longitudinal clinical information extracted from electronic medical records. Supervised machine learning models random...
Background and Objective Potentially significant associations between metabolic syndrome (MetS) periodontitis have been reported in recent studies; however, there are limited data on their association the very old. The aim of this cross‐sectional study was to investigate MetS among 80‐year‐old Japanese subjects. Material Methods subjects were 234 aged 80 years old who participated a health periodontal examination June 2008 Niigata city, Japan, classified into three groups: (i) severe...
Antidepressants are known to cause hyponatremia, but conflicting evidence exists regarding specific antidepressants. To identify antidepressants less likely we conducted a triangulation study integrating retrospective cohort, disproportionality, and pharmacodynamic studies. In the cohort of patients (≥ 60 years) in Nihon University School Medicine's Clinical Data Warehouse (2004-2020), significant decrease serum sodium levels was observed within 30 days after initiation selective serotonin...
Background: Acute kidney injury (AKI), with an increase in serum creatinine, is a common adverse drug event. Although various clinical studies have investigated whether combination of two nephrotoxic drugs has increased risk AKI using traditional statistical models such as multivariable logistic regression (MLR), the evaluation metrics not been evaluated despite fact that may over-fit data. The aim present study was to detect drug-drug interactions by interpreting machine-learning avoid...
To simultaneously estimate how the risk of incident dementia nonlinearly varies with administration period and cumulative dose benzodiazepines, duration disorders an indication for other potential confounders, goal settling controversy over role benzodiazepines in development dementia.The classical hazard model was extended using techniques multiple-kernel learning. Regularised maximum-likelihood estimation, including determination hyperparameter values 10-fold cross-validation, bootstrap...
Drug-induced liver injury (DILI) is a common adverse drug event. Spontaneous reporting systems such as the Japanese Adverse Event Report Database (JADER) have been used to evaluate association between drugs and events. However, of with events may be overestimated due biases. Therefore, it important objectively using function test values. The aim present study was predict potential hepatotoxic real-world data including electronic medical records JADER database. A total 70009 (2779 DILI 67230...
Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in remodeling is unknown. Here, we performed silico analysis to investigate alterations cardiomyocytes induced by [sevoflurane (Sevo)] [propofol (Prop)] anesthetics. Bioinformatics revealed that nuclear factor‐kappa B (NF‐kB) was inhibited Sevo promoted Prop. Moreover, accumulation p65 transcription NF‐kB‐regulated genes were suppressed...
A subset of prostate cancer displays a poor clinical outcome. Therefore, identifying this prognostic within clinically aggressive groups (defined as Gleason score (GS) ≧8) and developing effective treatments are essential if we to improve survival. Here, performed bioinformatics analysis TCGA dataset (GS identify pathways upregulated in cohort with short When conducting analyses, the definition factors such "overexpression" "shorter survival" is vital, may lead mis-estimations. To eliminate...
// Hidekazu Yoshie 1, 2, * , Anna S. Sedukhina Kimino Minagawa 1 Keiko Oda Shigeko Ohnuma 3 Nobuyuki Yanagisawa Ichiro Maeda Masayuki Takagi Hiroya Kudo 2 Ryuto Nakazawa Hideo Sasaki Toshio Kumai Tatsuya Chikaraishi and Ko Sato Department of Pharmacogenomics, St. Marianna University, Kawasaki, Japan Urology, Pathology, These authors have contributed equally to this work Correspondence to: Sato, email: kosato@marianna-u.ac.jp Keywords: bioinformatics, precision oncology, prostate cancer,...
Abstract Rationale Despite variants in the Dlgap1 gene having two lowest p -value a genome-wide association study of obsessive compulsive disorder (OCD), previous studies reported absence OCD-like phenotypes knockout (KO) mice. Since these observed behavioral only for short period, development mice at older ages was still plausible. Objective To examine presence or KO and their responsiveness to fluvoxamine. Methods results Newly produced were year. Modified SHIRPA primary screen 2-month-old...
<title>Abstract</title> The overexpression of Polo-like kinase 1 (PLK1) is linked to poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement homologous recombination (HR), the impact its on HR remains unclear. We investigated effect PLK1 using bioinformatics and experimental approaches. Analyzing Cancer Genome Atlas (TCGA) Cell Line Encyclopedia (CCLE) datasets with Homologous Recombination...
The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement homologous recombination (HR), the impact its on HR remains unclear. In this study, we investigated effect PLK1 using bioinformatics and experimental approaches. Analyzing Cancer Genome Atlas (TCGA) Cell Line Encyclopedia (CCLE) datasets Homologous Recombination Deficiency...
Abstract SGLT2 inhibitors show promise in reducing hospitalization for heart failure diabetics, but their long‐term effects and time‐dependency remain unclear. We conducted a retrospective nested case–control study within large type 2 diabetic cohort ( n = 11,209) using electronic health records. Cases (heart hospitalization, 352) were matched to controls 1372) based on age, sex, entry date, diabetes duration. Matched‐set conditional logistic regression was used estimate hazard ratios (HRs)...
Drug-induced liver injury (DILI) is a common adverse drug reaction, with abnormal elevation of serum alanine aminotransferase (ALT). Several clinical studies have investigated whether combination two drugs alters the reporting frequency DILI using traditional statistical methods such as multiple logistic regression (MLR), but this model may over-fit data. This study aimed to detect synergistic interaction between on risk ALT in Japanese adult patients three machine-learning algorithms: MLR,...
Antidepressants are known to cause hyponatremia, but conflicting evidence exists regarding specific antidepressants. To identify antidepressants less likely we conducted a triangulation study integrating retrospective cohort, disproportionality, and pharmacodynamic studies. In the cohort study, significant decrease in serum sodium levels was observed for selective serotonin reuptake inhibitors (SSRIs) serotonin-noradrenaline (SNRIs), whereas no found noradrenergic serotonergic antidepressant...
<h3>Objective</h3> Post-concussion syndrome after traffic accident is often clinically associated with prolonged cognitive impairment due to brain lesions, but sometimes a symptom like amnesia may occur without structural abnormality in neuroimaging. The question whether be caused by subtle lesions that cannot detected conventional MRI or CT. We report case which measurement of function functional Magnetic Resonance Imaging (fMRI) was useful assess the organic origin an amnesic disorder...