A5048761496- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Epilepsy research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Dental Anxiety and Anesthesia Techniques
- Mitochondrial Function and Pathology
- Anesthesia and Pain Management
- Retinal Development and Disorders
- Respiratory Support and Mechanisms
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Retinal Diseases and Treatments
- Obstructive Sleep Apnea Research
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Heme Oxygenase-1 and Carbon Monoxide
- Tracheal and airway disorders
- Blood transfusion and management
- Schizophrenia research and treatment
- Blood donation and transfusion practices
- Electroconvulsive Therapy Studies
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
Okayama University Hospital
2016-2025
Okayama University
2001-2022
University of Wisconsin–Madison
2010-2020
In Brief BACKGROUND: Clonidine, an α-2 adrenoceptor agonist, is a common adjunct in both central and peripheral blocks. Dexmedetomidine, more selective also known to enhance neural blockades. Its effect, however, has not been fully elucidated. Thus, we evaluated the effect of dexmedetomidine other agonists on local anesthetic action lidocaine at periphery explored mechanism involved. METHODS: Adrenoceptor agonists, including dexmedetomidine, clonidine, oxymetazoline, combined with were...
While the aging process is central to pathogenesis of age-dependent diseases, it poorly understood at molecular level. We identified a mouse mutant with accelerated in retina as well pathologies observed retinal suggesting that responsible gene regulates aging, and its impairment results disease. determined mutation transmembrane 135 (Tmem135) for these phenotypes. localization TMEM135 on mitochondria, imbalance mitochondrial fission fusion Tmem135 overexpressing cells, indicating involved...
We retrospectively analyzed the safety of use articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated Thailand 2015-2017. The dosage, adverse events (AEs) caused by anesthesia, and treatment efficacy were examined. Articaine, which is safe for with liver impairments due to its unique metabolism, has not been thoroughly tested Japan doses above 5.1 mL. Eighty present had undergone root canal (RCT), 71 underwent tooth extraction, 149 implant-related surgery. More...
Intracellular trafficking is critical for delivering molecules and organelles to their proper destinations carry out normal cellular functions. Disruption of intracellular has been implicated in the pathogenesis various neurodegenerative disorders. In addition, a number genes involved vesicle/organelle are also essential pigmentation, loss those often associated with mouse coat-color dilution human hypopigmentary Hence, we postulated that screening mutants both neurological defects will help...
Dexmedetomidine, a highly selective agonist of α2-adrenoceptors, is commonly used sedative; however, potent anti-inflammatory effect has also been found. In the present study we evaluated inhibitory locally injected dexmedetomidine on inflammatory responses in region.Local inflammation was induced hindpaws male mice (aged 6-8 weeks) by intraplantar injection lambda-carrageenin. To offset central tested agents, different agents were blindly into left and right paws pairs comparison. The edema...
Abstract Symptom endorsements and item response patterns on the anxiety-present anxiety-absent items of State-Trait Anxiety Inventory Form Y (Spielberger, 1983) for 149 Japanese (99 living in Japan 50 studying United States) 76 American university students were compared. Although mean scores state trait comparable international States, both groups significantly higher than those students. These differences attributable to much that corresponded a lack positive feelings. had tendency inhibit...
Background and Objectives Recent research shows that locally injected dexmedetomidine enhances the local anesthetic potency of lidocaine via α-2A adrenoceptor subtype in guinea pigs. However, little is known about effect on peripheral vascular response. This study aimed to evaluate response, measuring skin blood flow area Methods Dexmedetomidine was intracutaneously at a volume 0.1 mL into backs pigs, further combined with yohimbine, selective antagonist α-2 adrenoceptors, or prazosin, α-1...
Abstract Background The poor quality of oral health care for people with intellectual disability (ID) has been recognized, and the strong fears about dental treatment suggested as a major reason disturbances visits to dentists by such patients. Intravenous sedation is useful method relieving anxiety fear patients treatment, frequently essential ID undergoing treatment. However, decision regarding dose sedative required be administered an adequate level difficult because effect cannot...
Some dental patients have histories of adverse reactions to local anesthesia. The aim the present study was investigate frequency allergy anesthetics who had anesthesia based on results tests in our institute over a period 5 years. We investigated past medical records retrospectively, and twenty were studied. Three 20 showed positive or false-positive reaction intracutaneous test, one patient challenge test. Our suggest that is low even if However, should be performed whom it uncertain...
Some patients with intellectual disabilities spend longer than others in emergence from ambulatory general anesthesia for dental treatment. Although antiepileptic drugs and anesthetics might be involved, an independent predictor delay of the remains unclear. Thus, a purpose this study is to identify factors affecting anesthesia. This was retrospective cohort disabilities. Patients need sedative premedication were removed participants. The outcome time until Stepwise multivariate regression...
Tissues with high-energy demand including the heart are rich in energy-producing organelles, mitochondria, and sensitive to mitochondrial dysfunction. While alterations function increasingly recognized cardiovascular diseases, molecular mechanisms through which changes mitochondria lead abnormalities have not been fully elucidated. Here, we report that transgenic mice overexpressing a novel regulator of dynamics, transmembrane protein 135 (Tmem135), exhibit increased fragmentation disease...
Summary In sedation of dental patients with moderate or severe mental retardation, it is difficult to identify the optimum level and maintain appropriately. Moreover, many have concomitant epilepsy are medicated oral antiepileptic drugs (AEDs), which influence drug‐metabolizing enzymes. particular, valproate (VPA) has been demonstrated inhibit propofol metabolism in vitro. Therefore, objective present study was investigate clinical VPA on required dose for sedation, use a prospective cohort...
Orofacial pain is often difficult to diagnose and treat. However, there have been few reports on the clinical observation of dental patients with orofacial pain. We retrospectively investigated characteristics 221 who had suffered from persistent Data were collected outpatient medical records in our clinic over past 12 years. More than half (53.8%) for more 6 months onset until first visit clinic. The main diagnoses neuropathic (30.3%), myofascial (23.5%), psychogenic (20.4%), odontogenic...
Background Recently, attention has been focused on the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in mechanism and as a treatment target for neuropathic inflammatory pain. Ivabradine, blocker HCN channels, was demonstrated to have an effect pain animal model. Therefore, present study, we evaluated ivabradine pain, under hypothesis that can directly influence responses, investigated its vivo vitro studies. Methods After approval from our institution, studied...
Sedation may minimize physiologic and behavioral stress responses. In our facility, the infusion rate of propofol is adjusted according to bispectral index (BIS) in all cases implant-related surgery; multivariate analysis retrospective data enabled us extract independent factors that affect dose sedation are considered useful indicators for achieving adequate sedation. The study population comprised patients undergoing surgery under intravenous Okayama University Hospital from April 2009...
The oral administration of midazolam has often been used for sedation in pediatric patients. However, an intravenous formulation is difficult younger patients because its bitter taste. Liposomes have developed as vesicles encapsulating various kinds drugs to serve a medical drug-delivery system. Thus, the aim present study was produce pH-sensitive liposomes and evaluate pharmacokinetics on rabbits. Liposome-encapsulated produced from hydrogenated L-α-phosphatidylcholine, cholesterol,...