A5061553422- Colorectal Cancer Surgical Treatments
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Neurofibromatosis and Schwannoma Cases
- Cancer Treatment and Pharmacology
- Anatomy and Medical Technology
- Genetic factors in colorectal cancer
- Surgical Simulation and Training
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
Gifu University
2016-2025
Gifu University Hospital
2005-2024
Gifu Prefectural General Medical Center
2010-2018
Oji General Hospital
1999
In recent years, laparoscopic surgery has been widely used for rectal cancer. surgery, a double-stapling technique (DST) anastomosis using stapling device is considered relatively difficult procedure. Postoperative anastomotic leakage (AL) major complication related to patients' quality of life and prognosis.This study was retrospective, single-institution 101 cancer patients who underwent low anterior resection (LAR) with DST (excluding simultaneous other organs construction protective...
Posttreatment detection of ctDNA is strongly predictive recurrence. Most minimal/molecular residual disease assays require prior tissue testing to guide analysis, resulting in lengthy time initial results and unevaluable patients.
Complex surgery during initial cancer treatment can limit surgical options when planning management of a secondary malignancy. Subtotal esophagectomy and pancreatoduodenectomy are the most invasive difficult procedures in gastroenterological surgery. Surgical cases which subtotal was performed after with pancreaticogastrostomy extremely rare challenging due to resulting complicated anatomical changes. A 60-year-old man history conversion for advanced pancreatic head diagnosed as having...
257 Background: Disappearing liver metastases (DLMs) diagnosed on post-chemotherapy (Cx) computed tomography (CT) is a favorable prognostic factor in patients (pts) with colorectal (CRLM). However, the optimal treatment of DLMs - whether they should be resected or left behind controversial. This prospective, multi-centred, international study examining added value MRI (DWI, T1/T2 and contrast-enhanced) to that CT alone accurate assessment viability DLMs. Methods: Pts initially unresectable...
The right top pulmonary vein (RTPV) is a rare anatomical variant that arises independently of the superior lobe. It drains behind main bronchus or intermedius and into left atrium another vein. This anomaly poses challenges during subcarinal lymph node dissection in thoracic surgery, such as esophagectomy, owing to risk vascular injury. RTPV mainly located intermediate bronchus; however, reports focusing on these sites are lacking. Herein, we present case esophageal cancer with an was...
5-Fluorouracil (5-FU) plays a major role in the treatment of gastric cancer (GC), and overcoming resistance to this drug remains critical challenge. This study aimed identify genes associated with 5-FU GC. Gene expression levels were analyzed 5-FU-resistant MKN-45/F2R cells compared parental MKN-45 strain before after (24 72 h). Among consistently over-expressed genes, those high further investigated for their roles patterns GC tissues. NPC1L1, protein hypothesized influence resistance, did...
Schwannomas arise from Schwann cells of the peripheral nerve sheath. are usually benign, and most them located in head, neck, or distal extremities. The retroperitoneal region is an unusual location for schwannomas. seen adults very rare pediatric population. A 6-year-old boy was referred to our institution with a right abdominal mass. His main complaint intermittent myoclonus his lower limb. Abdominal computed tomography (CT) magnetic resonance imaging scans revealed round-shaped solid mass...
The prognosis of esophageal cancer patients is still unsatisfactory. Although a docetaxel, cisplatin, and 5-Fu (DCF) regimen has been reported, it often difficult to accomplish because severe toxicity. Therefore, we developed new biweekly DCF (Bi-DCF) previously reported the recommended dose in phase I dose-escalation study. We then performed II study Bi-DCF for advanced squamous cell carcinoma (SCC). Patients with clinical stage II/III were eligible. received 2 courses chemotherapy:...
Although the efficacy of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) against metastatic colorectal cancer (mCRC) has been demonstrated, little is known about its effectiveness upon disease stratification by RAS mutations. In this phase II study, we investigated and safety profiles FTD/TPI in mCRC according to mutation status.Eligible patients were refractory or intolerant all standard therapies other than regorafenib. Patients received 4-week cycles treatment with (35 mg/m2,...
•The efficacy of anti-PD-1 therapy in dMMR LARC patients is promissing responses.•The VOLTAGE-2 study investigates the and safety 1-year nivolumab.•Patients with cCR or nCR will be observed NOM.•WGS-based MRD assay used as surrogacy cCR.•WES/WTS-based tumor genomics immune microenvironment evaluated. BackgroundNeoadjuvant radiotherapy chemotherapy, followed by surgical resection, are standard treatments for locally advanced rectal cancer (LARC). Emerging evidence has shown anti-programmed...
Between April 2005 and December 2012, we performed laparoscopic colorectal resection with regional lymph node dissection on 273 cases of cancer patients. However, Laparoscopic rectal surgery requires a high degree skill. Any surgeon who is going to embark these difficult resections should have at minimum suturing skills in order be able close the peritoneal defect.In for cancer, intracorporeal suture technique required pelvic cavity very difficult. Barbed sutures recently been proposed...
Even if 3D angiographic images of preoperative contrast-enhanced computed tomography (CT) are created, the coronal and axial sections can be unclear, thus, it is difficult to achieve projection awareness similar that actual laparoscopic images. In recent years, technology analyzing applying medical has advanced, surgical simulation navigation have been widely used improve safety operations. It important understand pelvic anatomy in area rectal cancer, use SYNAPSE VINCENT makes possible...
The anatomical pattern of lymph nodes spread differs between young (aged 45 years or younger) and elderly 80 older) patients with stage III colon cancer is poorly investigated.
The aim of the present study was to evaluate short-term surgical outcomes laparoscopic intersphincteric resection (ISR) for a lower rectal tumor in comparison with case-control series patients undergoing open ISR. Quality life factors and anal function were also evaluated. Between July 2008 April 2013, 103 cancer underwent surgery at Surgical Oncology Department Gifu University School Medicine. A total 25 ISR, 19/25 who ISR compared control group 6 technical feasibility safety short-...
Several biomarkers have been established for metastatic colorectal cancer (mCRC). We investigated whether plasma angiogenesis factors could predict the efficacy of biologics combined with chemotherapy in first-line (1L) treatment patients RAS wild-type mCRC and dynamics at progression during 1L treatment.In this multicenter prospective observational study, serial samples were prospectively collected pretreatment stages; 17 analyzed using multiplex assay Luminex® technology. Interactions...
The most common postoperative complication in malignant rectal surgery is anastomotic leakage (AL). AL after anterior or low resection tumors a fatal complication. Recently, the first automated suture circular stapler, which expected to reduce incidence of AL, (J&J). MATERIALS AND METHODS: This study included total 248 tumor patients who underwent double stapler technique (DST) procedures department gastroenterological /pediatric at Gifu University School Medicine from January 2017 December...
Background/Aim: A three-dimensional network constructed using glycocalyx (GCX) extends throughout the cancer cell nest in human colorectal (CRC). GCX was found to be closely related cancer. We examined prognostic correlation and potential of syndecan-1 (SDC1), a representative proteoglycan GCX, as biomarker. Patients Methods: analyzed SDC1 transcriptomic profiles major publicly available CRC cohort from The Cancer Genome Atlas (TCGA) computational algorithm. investigated serum levels...
Owing to advances in cancer treatment and the diversification of methods, cancer-associated thrombosis is increasing. Cancer can cause blood clots by activating clotting system, increasing factors through inflammation, reducing flow due immobilization damaging vessels treatments such as chemotherapy. In clinical practice, superior mesenteric vein (SMV) occasionally observed patients with cancer; however, certain cases asymptomatic be serious. present case, a 71-year-old woman underwent...
We conducted a randomized phase III trial comparing tegafur/uracil (UFT) and Polysaccharide-K (PSK) to surgery alone in curatively resected stage II rectal cancer patients. Patients were randomly assigned receive either UFT PSK or 1:1 ratio with minimization method balance the treatment allocation. The primary end point of this study was disease-free survival (DFS). secondary overall (OS). From October 2011 February 2013, 111 patients registered from 62 institutions. prematurely closed due...
Abstract Purpose Malignant large-bowel obstruction (MLBO) is a highly urgent condition in colorectal cancer with high complication rates. Self-expandable metal stent (SEMS) placement MLBO new decompression treatment Japan. Preoperative (bridge to surgery: BTS) avoids emergency surgery, but oncological influences of and post-BTS surgical approach remain unclear. We examined short- long-term results surgery for after SEMS our hospital. Methods retrospectively reviewed 75 patients who underwent...
Metastasis to the urinary bladder from gastric cancer is rare. a diverticulum of extremely We report case isolated metastasis and invasion localized muscularis propria primary site (stomach).A 90-year-old female presented with nausea vomiting that was diagnosed as cancer, patient also had intermittent hematuria. Pelvic computed tomography identified an abnormally thickened area in wall bladder. A biopsy revealed well differentiated tubular adenocarcinoma metastatic carcinoma.Almost all cases...
The present study reports the case of a patient with rectal submucosal tumor (leiomyoma) that was resected transvaginally. A 51-year-old female presented on anterior wall lower rectum, located within 3 cm anal verge. This location would normally require intersphincteric or abdominal perineal resection. However, in order to minimize invasiveness treatment and reduce post-operative morbidity, transvaginal resection laparoscopic diverting ileostomy were performed instead. With under general...
Prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) indicate status host immunity. We used immunohistochemistry apparent diffusion coefficient (ADC) values calculated using diffusion-weighted imaging (DWI) to investigate relationships of these factors with pathological radiological characteristics in rectal cancer treated neoadjuvant chemoradiotherapy (nCRT).We evaluated expression levels VEGFA, CD8, CD33, ADC tumors pre/post nCRT; analyzed the between those PNI, NLR...