A5002748194- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Body Composition Measurement Techniques
- Cholesterol and Lipid Metabolism
- Diabetes Management and Research
- Liver physiology and pathology
- Pancreatic function and diabetes
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Frailty in Older Adults
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Liver Diseases and Immunity
- Immune Response and Inflammation
- Nutrition and Health in Aging
- Fatty Acid Research and Health
- RNA Research and Splicing
Tokyo Medical and Dental University
2013-2024
Type 2 diabetes mellitus (T2DM) is associated with a high incidence of non-alcoholic fatty liver disease (NAFLD) related to obesity and insulin resistance. Currently, medical interventions for NAFLD have focused on diet control exercise reduce body weight, there requirement effective pharmacological therapies. Sodium-glucose cotransporter (SGLT2) inhibitors are oral antidiabetic drugs that promote the urinary excretion glucose by blocking its reabsorption in renal proximal tubules. SGLT2...
Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined preventive effects inhibitor canagliflozin (CANA) Western diet (WD)-fed melanocortin 4 receptor-deficient (MC4R-KO) mice, a mouse model human NASH. An eight-week CANA treatment...
Obesity promotes infiltration of inflammatory cells into various tissues, leading to parenchymal and stromal cell interaction development cellular organ dysfunction. Liver sinusoidal endothelial (LSECs) are the first that contact portal blood substances in liver, but their functions obesity-associated glucose metabolism remain unclear. Here, we find LSECs involved accumulation myeloid via VLA-4-dependent cell-cell adhesion. VLA-4 blockade mice fed a high-fat diet attenuated liver improve...
Abstract Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PFD improves liver fibrosis in a mouse model human NASH-like phenotypes. In this study, we employed melanocortin 4 receptor-deficient (MC4R-KO) mice as phenotypes to elucidate effect action...
The adipose tissue includes various stromal cells, such as preadipocytes, endothelial fibroblasts, and immune which are involved in functions. We previously reported that, obese mice, the sodium-glucose cotransporter 2 inhibitor ipragliflozin (Ipra) promoted expansion of epididymal (Epi) with increase serum ketone body concentration. Ipra-induced did not deteriorate inflammation, or systemic glucose/lipid metabolism, referred to "healthy expansion." Here we found that Ipra healthy a reduced...
Abstract Aim To evaluate the association between sarcopenic obesity and decline in estimated GFR people with type 2 diabetes. Methods We enrolled 745 diabetes (mean age 64.6 years, 53.6% men). Body composition was evaluated using dual‐energy X‑ray absorptiometry. Skeletal muscle index, calculated as appendicular non‐fat mass (kg) divided by height squared (m ), used to determine sarcopenia. Sarcopenic defined coexistence of sarcopenia a ratio android gynoid fat greater than median values...
Primary bilateral macronodular adrenal hyperplasia (PBMAH), a rare cause of Cushing syndrome, is often diagnosed as incidentaloma with subclinical cortisol production. Circulating microRNAs (miRNAs) are characteristic adrenocortical adenomas, but miRNA expression in PBMAH has not been investigated. We aimed to evaluate the circulating patients and compare them those non-functioning adenoma (NFA) cortisol-producing (CPA).miRNA profiling plasma samples from four, five, five NFA, CPA, PBMAH,...
Adipose-derived stem cells are expected to be applied regenerative medicine for various incurable diseases including liver cirrhosis. Although microRNAs contained in extracellular vesicles (EV-miRNAs) have been implicated their effects, the precise mechanism has not fully elucidated. Tamoxifen-inducible adipocyte-specific insulin receptor knockout (iFIRKO) mice known exhibit acute adipose tissue regeneration with increased numbers of and progenitor (ASPCs). Because is major source...
BACKGROUND: Recent advances in omics techniques have allowed detailed genetic characterization of aldosterone-producing adenoma (APA). The pathogenesis APA is characterized by tumorigenesis-associated aldosterone synthesis. pathophysiological intricacies APAs not yet been elucidated at the level individual cells. Therefore, a single-cell analysis speculated to be valuable studying differentiation process APA. METHODS: We conducted single-nucleus RNA sequencing with KCNJ5 mutation and...
Abstract Brown adipose tissue (BAT), a thermogenic that plays an important role in systemic energy expenditure, has histological and functional sex differences. BAT activity is higher female mice than male mice. However, the molecular mechanism underlying this difference not been fully elucidated. Herein, we demonstrate of PGC-1α difference. Inducible adipocyte-specific knockout (KO) displayed decreased thermogenesis only females. Expression carbohydrate response-element binding protein beta...
Sitosterolemia is caused by homozygous or compound heterozygous gene mutations in either ATP-binding cassette subfamily G member 5 (ABCG5) 8 (ABCG8). Since ABCG5 and ABCG8 play pivotal roles the excretion of neutral sterols into feces bile, patients with sitosterolemia present elevated levels serum plant some cases also hypercholesterolemia. A 48-year-old woman was referred to our hospital for She had been misdiagnosed familial hypercholesterolemia at age 20 her low-density lipoprotein...
Primary aldosteronism (PA) is a major cause of secondary hypertension and associated with chronic renal injury. The glomerular filtration rate (GFR) in PA rapidly decreases after the removal hyperfiltration due to aldosterone excess by adrenalectomy (ADX) or mineralocorticoid receptor antagonist (MRA) treatment stable long term. However, effects these treatments on long-term function patients kidney disease (CKD) not well understood.In this single-center, retrospective study, acute changes...