A5101653875- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Bone Metabolism and Diseases
- Heat shock proteins research
- Inflammatory mediators and NSAID effects
- Bone health and osteoporosis research
- Veterinary Orthopedics and Neurology
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Spaceflight effects on biology
- Sports injuries and prevention
- Spine and Intervertebral Disc Pathology
- Elbow and Forearm Trauma Treatment
- Nerve Injury and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Cell death mechanisms and regulation
- Musculoskeletal synovial abnormalities and treatments
- Bone health and treatments
- Healthcare and Venom Research
- Nasal Surgery and Airway Studies
- Platelet Disorders and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Melanoma and MAPK Pathways
- Signaling Pathways in Disease
Gifu University
2018-2023
Loma Linda University Medical Center
2023
Loma Linda University
2023
East Kent Hospitals University NHS Foundation Trust
2022
Kangbuk Samsung Hospital
2021
Sungkyunkwan University
2021
Dongguk University Ilsan Hospital
2019
Khanh Hoa General Hospital
2019
Seoul National University Bundang Hospital
2015
Seoul National University
2013
Differential diagnosis of patients with bilateral lung infiltrates remains a difficult problem for intensive care clinicians. Here we evaluate the diagnostic role soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in bronchoalveolar lavage (BAL) specimens from infiltrates.We conducted prospective observational study 80 clinical suspicion infectious pneumonia. Patients were categorized into three groups: bacterial or fungal infection, intracellular viral and noninfectious...
Humeral retroversion is variable among individuals, and there are several measurement methods. This study was conducted to compare the concordance reliability between standard method 5 other methods on two-dimensional (2D) computed tomography (CT) scans.CT scans from 21 patients who underwent shoulder arthroplasty (19 women 2 men; mean age, 70.1 years [range, 42 81 years]) were analyzed. The elbow transepicondylar axis used as a distal reference. Proximal reference points included central...
Olive oil polyphenols, which possess cytoprotective activities like anti-oxidant and anti-inflammatory effects, could modulate osteoblast functions. The aim of this study is to elucidate the effects underlying mechanisms hydroxytyrosol oleuropein on tumor necrosis factor-α (TNF-α)-induced macrophage colony-stimulating factor (M-CSF) interleukin-6 (IL-6) synthesis in osteoblasts.Osteoblast-like MC3T3-E1 cells were pretreated with hydroxytyrosol, oleuropein, deguelin, PD98059 or wedelolactone,...
The aim of this study was to evaluate clinical experience with arthroscopic debridement for septic arthritis the shoulder joint and report on our patient outcomes.The retrospective analysis included 36 shoulders (male:female, 15:21), contributed by 35 patients (mean age, 63.8 years) treated arthroscopy between November 2003 February 2016. mean follow-up period 14.3 months (range, 12-33 months). An additional posterolateral portal a 70º arthroscope used access posteroinferior glenohumeral...
Tramadol is a useful analgesic which acts as serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic modulates the small GTPase activity through serotonylation, closely related human platelet activation. We recently reported that combination of subthreshold collagen CXCL12 synergistically activates platelets. herein investigated effect mechanism tramadol on synergistic effect. attenuated stimulated aggregation (300 μM tramadol, 64.3% decrease,...
Rehabilitation and overuse of the shoulder after rotator cuff repair are a concern in patients with comorbid disability other extremities. Improvement outcomes can be hampered this situation. This study was to describe clinical extremities.In two tertiary institutions, 16 (9 men 7 women; mean age 57.1 years [range, 45 71 years]; 14 dominant arms; follow-up 18 months 12 38 months]) underwent repair. There were 5 massive tears, 1 large tear, 9 medium small tear. Open performed 3 arthroscopic...
The IL28B genotype is a critical determinant of interferon response in patients infected with hepatitis C virus 1. We describe an allele-specific PCR assay for the genotype. simple and robust, uses commonly available real-time instrumentation, well suited clinical laboratories offering genotyping.
Background: We have recently reported that epidermal growth factor (EGF) induces migration of osteoblast-like MC3T3-E1 cells through the activation p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP stress-activated kinase/ c-Jun N-terminal kinase (SAPK/JNK) and Akt. Furthermore, we demonstrated heat shock 70 (HSP70) down-regulates transforming factor-β- stimulated vascular endothelial synthesis via suppression in cells. However, exact role HSP70 underlying osteoblast is not fully...
Heat shock protein 90 (HSP90) is expressed ubiquitously in a variety of cell types including osteoblasts. HSP90 acts as key driver proteostasis under pathophysiological conditions. Here, we investigated the involvement extracellular ATP‐stimulated interleukin (IL)‐6 synthesis and downstream signalling osteoblast‐like MC3T3‐E1 cells. In osteoblasts, ATP stimulates IL‐6, bone‐remodelling agent. Geldanamycin, 17‐allylamino‐17‐demethoxy‐geldanamycin (17‐AAG) onalespib, three different...
Migration of osteoblasts to the sites resorbed by osteoclasts is an essential step in bone remodeling. However, exact mechanism osteoblast migration still not known. We have shown that platelet-derived growth factor (PDGF)-BB induces osteoblast-like MC3T3-E1 cells through activation p38 mitogen-activated protein (MAP) kinase, c-Jun N-terminal kinase (JNK) and p44/p42 MAP kinase. Evidence accumulating heat shock 90 (HSP90) acts as a central regulator proteostasis under stress conditions...
Wnt3a is a crucial modulator of bone metabolism through the canonical Wnt/β-catenin signaling pathway in bone-forming osteoblasts. We previously reported that expression osteocalcin stimulated by triiodothyronine (T3) at least part activation p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP osteoblast-like MC3T3-E1 cells. In present study, we investigated effect on T3-induced these suppressed release induced T3. The inhibitory was dose-dependent between 0.3 and 30 ng/ml....
Abstract Background The role of altered joint mechanics on cartilage degeneration in vivo models has not been studied successfully due to a lack pre-injury information. We aimed 1) develop an accurate canine model measure the changes loading and T2 star (T2*) relaxation time before after unilateral supraspinatus tendon resections, 2) find relationship between regional variations articular patterns T2* distributions. Methods Rigid markers were implanted scapula humerus tested dogs. movement...
Abstract Resveratrol is a natural polyphenol with beneficial antioxidant properties. It suppresses the migration of osteoblast-like MC3T3-E1 cells induced by epidermal growth factor, via SIRT1-mediated inhibition SAPK/JNK and Akt. Moreover, insulin-like factor-I (IGF-I) stimulates involving pathways p44/p42 mitogen-activated protein (MAP) kinase Therefore, we investigated effects resveratrol on IGF-I-induced cell migration. SRT1720, an activator SIRT1, suppressed Inauhzin, SIRT1 inhibitor,...
Duloxetine, a selective serotonin-norepinephrine reuptake inhibitor, is currently recommended for the treatment of chronic painful disorders such as fibromyalgia, musculoskeletal pain, and diabetic peripheral neuropathy. We previously demonstrated that bone morphogenetic protein-4 (BMP-4) stimulates osteoprotegerin (OPG) production in osteoblast-like MC3T3-E1 cells, p70 S6 kinase positively regulates OPG synthesis. The present study aimed to investigate effect duloxetine on BMP-4-stimulated...
Noh, Jung Ho MD, PhD; Song, Sang Jun Bae, Ji Yoon MD; Roh, Young Hak Kim, Woo Gyu Yang, Bo MD Author Information
Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed induced in response to stress many cell types. We have previously demonstrated that transforming growth factor-β (TGF-β), the most abundant cytokine bone cells, induces expression of HSP27 through Smad2, p44/p42 mitogen-activated kinase (MAPK), p38 MAPK, stress-activated kinase/c-Jun N-terminal (SAPK/JNK) mouse osteoblastic MC3T3-E1 cells. This study investigated effects HSP90 on TGF-β-induced...
Acetaminophen is one of the most widely used analgesic and antipyretic medicines, whose long-period use has reportedly been associated with an increased risk bone fracture. However, mechanism underlying this undesired effect remains to be investigated. The homeostatic control tissue depends on interaction between osteoblasts osteoclasts. Osteoprotegerin produced by known play essential role in suppressing osteoclast induction. We have previously reported that prostaglandin (PG) E2 PGF2α...