A5086446140- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Ion channel regulation and function
- Obsessive-Compulsive Spectrum Disorders
- Cardiac electrophysiology and arrhythmias
- Personality Disorders and Psychopathology
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Mental Health Research Topics
- Receptor Mechanisms and Signaling
- Cardiovascular Disease and Adiposity
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Metabolomics and Mass Spectrometry Studies
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Adrenal Hormones and Disorders
National Center of Neurology and Psychiatry
2015-2024
Osaka Medical and Pharmaceutical University
2009-2017
Shin Nippon Biomedical Laboratories (Japan)
2006-2017
University of Yamanashi
2015
Toho University
2014-2015
National Institute of Health Sciences
2014-2015
Kindai University
2007-2012
Kumamoto University
2005
Nagasaki University
1981-1982
Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain has neuroprotective effects, but clinical evidence is still scarce. Here we examined effect of MCT-based formula on cognitive function in patients with Alzheimer's disease (AD). The subjects were 20 Japanese mild-to-moderate AD (11 males, nine females, mean age 73.4 ± 6.0 years) who, separate days, underwent neurocognitive tests 120 min after...
Abstract Aim We aimed to examine the gut permeability in patients with schizophrenia and its relevance symptoms, medication, cognitive functions, blood immune markers. Methods selected 22 (mean age: 37.9 ± 10.5 years) comprising 9 men 13 women. Furthermore, we included 86 healthy controls 43.5 11.0 41 45 All participants were biologically unrelated of Japanese descent. used Positive Negative Syndrome Scale (PANSS) Brief Assessment Cognition Schizophrenia (BACS) measure severity symptoms...
Autism spectrum disorder often co-occurs with other psychiatric disorders. Although a high prevalence of autistic-like traits/symptoms has been identified in the pediatric population normal intelligence, there are no reports from adult population. This study examined whether is greater patients adult-onset disorders such as major depressive (MDD), bipolar disorder, or schizophrenia, and an association independent symptom severity. The subjects were 290 adults intelligence between 25 59 years...
Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia well mood disorders. Some evidence suggests that this polymorphism plays role in cognitive function both patients and healthy individuals; however, precise nature remains unclear. Here we investigated possible with wide range neurocognitive functions subjects. Schizophrenia exhibited significantly poorer performance on all domains compared to controls. In patients,...
Amino acids play key roles in the function of central nervous system, and their alterations are implicated psychiatric disorders. In search for a biomarker major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino related molecules cerebrospinal fluid (CSF) 52 patients with MDD (42 depressed 10 remitted; DSM-IV) 54 matched controls. Significant differences were found four acid concentrations between After Bonferroni correction, only ethanolamine (EA)...
Abstract To examine the role of neuroplasticity in pathology psychiatric disorders, we measured cerebrospinal fluid (CSF) neuroplasticity-associated protein levels. Participants were 94 patients with schizophrenia, 68 bipolar disorder (BD), 104 major depressive (MDD), and 118 healthy controls, matched for age, sex, ethnicity (Japanese). A multiplex immunoassay (22-plex assay) was performed to measure CSF Among 22 proteins, 11 successfully assay. amyloid precursor (APP) glial cell-derived...
Recently great attention has been paid to the still unmet clinical needs of most adults with autism spectrum disorder (ASD) who live in community, an increasing number whom visit psychiatric clinics seek accurate diagnosis and treatment concurrent symptoms. However, different from case children diagnosed ASD childhood, it is difficult identify symptoms underlying psychopathology differentiate other disorders general practice. This study aimed verify utility Social Responsiveness Scale-Adult...
Abstract The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Binding Protein 5 ( FKBP5 ) gene has been reported to be associated with an altered response hypothalamic-pituitary-adrenal (HPA) axis and development stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD). In present study, we examined whether this SNP is cognitive function in a non-clinical population. full versions Wechsler Memory Scale-Revised Adult Intelligence were...
Aim: Accumulating evidence suggests that neural inflammation plays an important role in psychiatric disorders. We aimed to identify inflammatory cytokines involved the pathophysiology of such disorders by quantifying them cerebrospinal fluid (CSF) samples from a large sample patients with major and healthy controls. Methods: The subjects included 94 schizophrenia, 68 bipolar disorder, 104 depressive 118 controls, matched for age, sex, ethnicity (Japanese). Lumbar puncture was performed...
Background: The relationship between muscle strength and cognition in schizophrenia has not been well studied. We investigated the potential of handgrip (HGS) score body mass index (BMI) with cognitive function patients schizophrenia. Methods: Participants included 153 (age: 36.9 ± 9.4 years; 82 males) 328 healthy controls 36.4 10.7 150 males), matched for age, sex, ethnicity (Japanese). HGS was measured using a digital dynamometer. Cognitive evaluated Brief Assessment Cognition...
Patients with schizophrenia are at increased risk for suicide. Various factors suicide have been reported in schizophrenia; however, few studies examined the association between personality traits and suicidal behavior. We administered Schizotypal Personality Questionnaire (SPQ) to 87 Japanese patients (49 males; mean age 38.1±10.6 years) without a history of attempts (SA nSA groups, respectively), 322 controls (158 40.8±13.9 years). As expected, an analysis covariance (ANCOVA) controlling...
Evidence suggests that oral intake of medium-chain triglycerides (MCTs), which promote the production ketone bodies, may improve cognitive functions in elderly people; however, underlying brain mechanisms remain elusive. We tested hypothesis improvement accompanies physiological changes and reflects use bodies as an extra energy source. To this end, by using functional magnetic resonance imaging, cerebral blood oxygenation level-dependent (BOLD) signals were measured while 20 healthy...
Abstract Aim We aimed to compare neuropeptide levels between patients with major psychiatric disorders and healthy controls examine their association symptoms cognitive function. Methods The participants were 149 schizophrenia, 115 bipolar disorder (BD), 186 unremitted depressive (MDD), 350 controls. Psychiatric (schizophrenic, manic, depressive) symptoms, sleep state, (premorbid intelligence quotient, general cognitive, memory) functions evaluated. A multiplex immunoassay kit was used...