A5050723203- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Context-Aware Activity Recognition Systems
- Cardiac Health and Mental Health
- Mobile Health and mHealth Applications
- Total Knee Arthroplasty Outcomes
- Muscle metabolism and nutrition
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Hemodynamic Monitoring and Therapy
- Health Literacy and Information Accessibility
- Balance, Gait, and Falls Prevention
- Hip disorders and treatments
- Telemedicine and Telehealth Implementation
- Adipose Tissue and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Lower Extremity Biomechanics and Pathologies
- Social Media in Health Education
- Thermoregulation and physiological responses
- Hip and Femur Fractures
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
At Bristol
2024
University of Bristol
2017-2023
Southmead Hospital
2018-2023
University of Worcester
2020
University of Birmingham
2009-2018
University of Edinburgh
2014
NIHR Leicester Cardiovascular Biomedical Research Unit
2012
University of Oxford
2012
University of Cambridge
2012
University of Southampton
2012
<h2>Summary</h2><h3>Background</h3> Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place telemonitoring over alone is unclear. The TASMINH4 trial aimed to assess efficacy self-monitored blood pressure, with or without telemonitoring, for in primary care, compared usual care. <h3>Methods</h3> This study was a parallel randomised controlled done 142 general practices UK, included hypertensive patients older than 35...
We investigated the hypothesis that a program of prolonged endurance training, previously shown to decrease metabolic perturbations acute exercise within 5 days would result in greater adaptations after longer training duration. Seven healthy male volunteers [O2 consumption = 3.52 +/- 0.20 (SE) l/min] engaged consisting 2 h cycle at 59% pretraining peak O2 (VO2peak) 5-6 times/wk. Responses 90-min submaximal challenge were assessed (PRE) and 31 training. On basis biopsies obtained from vastus...
Human apolipoprotein B-100 (apoB-100), the ligand on low density lipoproteins that interacts with lipoprotein receptor and initiates receptor-mediated endocytosis catabolism, has been cloned, complete nucleic acid derived amino sequences have determined. ApoB-100 cDNAs were isolated from normal human liver cDNA libraries utilizing immunoscreening as well filter hybridization radiolabeled apoB-100 oligodeoxynucleotides. The mRNA is 14.1 kilobases long encoding a mature protein of 4536 acids...
The use of self-monitoring blood pressure, with or without telemonitoring, to guide therapy decisions by physicians for patients hypertension has been recently demonstrated reduce pressure compared using clinic monitoring (usual care). However, both the cost-effectiveness these strategies usual care, and whether additional benefit telemonitoring alone could be considered value money, are unknown. This study assessed physician titration antihypertensive medication self-monitored make...
<h3>Background</h3> Self-management of hypertension, comprising self-monitoring blood pressure with self-titration medication, improves control, but little is known regarding the views patients undertaking it. <h3>Aim</h3> To explore patients' and antihypertensive medication. <h3>Design setting</h3> Qualitative study embedded within randomised controlled trial TASMINH2 (Telemonitoirng Self Management in Control Hypertension) patient self-management hypertension from 24 general practices West...
Objectives To explore how healthcare practitioners (HCPs) made decisions about the implementation of digital health technologies (DHTs) in their clinical practice before and during COVID-19 pandemic. Design A multimethods study, comprising semistructured interviews conducted prior to pandemic, supplemented with an online survey that was pandemic a different sample, ensure qualitative findings remained relevant within rapidly changing context. Participants were recruited through HCP networks,...
This study aimed to determine the prevalence of Self-Monitoring Blood Pressure amongst people with hypertension using a cross-sectional survey. Of 955 who replied (53%), 293 (31%) reported that they self-monitored blood pressure. Nearly 60% (198/331) at least monthly. Diabetic patients monitoring their glucose were five times more likely than those not monitor Self-monitoring is less common in UK internationally, but practiced by enough warrant greater integration into clinical practice.
Background Home blood-pressure (BP) monitoring is recommended in guidelines and increasingly popular with patients health professionals, but the accuracy of patients’ own monitors real-world use not known. Aim To assess home BP used by people hypertension, to investigate factors affecting accuracy. Design setting Cross-sectional, observational study urban suburban settings central England. Method Patients ( n = 6891) on hypertension register at seven practices West Midlands, England, were...
Background Self-monitoring of blood pressure is common but how telemonitoring with a mobile healthcare (mHealth) solution in the management hypertension can be implemented by patients and professionals (HCPs) currently unclear. Aim Evaluation facilitators barriers to self- interventions for within Telemonitoring Hypertension (TASMINH4) trial. Design setting An embedded process evaluation TASMINH4 randomised controlled trial (RCT), West Midlands, UK primary care, conducted between March 2015...
apoB DNA, RNA, and protein from two patients with homozygous hypobetalipoproteinemia (HBL) were evaluated compared normal individuals. Southern blot analysis 10 different cDNA probes revealed a gene without major insertions, deletions, or rearrangements. Northern slot analyses of total liver mRNA HBL documented size that was present in greatly reduced quantities. ApoB detected within hepatocytes utilizing immunohistochemical techniques; however, it markedly quantity when control samples. No...
Self-monitoring of blood pressure is common but guidance on how it should be carried out varies and currently unclear such viewed.To explore patients' healthcare professionals' (HCPs) views experiences the use different self-monitoring regimens to determine what acceptable feasible, inform future recommendations.Thirteen focus groups four HCP interviews were held, with a total 66 participants (41 patients 25 HCPs) from primary secondary care without experience self-monitoring.Standard...
Abstract Background Innovation in healthcare technologies can result more convenient and effective treatment that is less costly, but a persistent challenge to widespread adoption health social care end user acceptability. The purpose of this study was capture UK public opinions attitudes novel (NHTs), better understand the factors contribute acceptance future use. Methods An online survey distributed between April May 2020. Respondents received brief information about four (NHTs)...
To investigate the hypothesis that training-induced increases in muscle mitochondrial potential are not obligatory to metabolic adaptations observed during submaximal exercise, regardless of peak aerobic power (V˙o 2 ) subjects, a short-term training study was utilized. Two groups untrained male subjects ( n = 7/group), one with high (HI) and other low (LO)V˙o (means ± SE; 51.4 0.90 vs. 41.0 1.3 ml ⋅ kg −1 min ; P< 0.05), cycled for h/day at 66–69% ofV˙o 6 days. Muscle tissue extracted...
A large number of quinic acid non-utilizing qut mutants Aspergillus nidulans deficient in the induction all three specific enzymes have been analysed. One class, qutD mutants, are recessive and non-inducible at pH 6·5 due to inferred deficiency a quinate ion permease. Two regulatory genes identified. The QUTA gene encodes an activator protein since most qutA although few fully dominant found. QUTR repressor mutations constitutive for enzyme activities. Rare which revert readily yield high...
Objective: To investigate the feasibility, acceptability and potential efficacy of group exercise for residents in care homes. Design: Exploratory cluster randomized controlled trial. Setting: Five randomly selected homes South Birmingham, UK. Participants: Fifty-six home (mean age 84.5, 71% female), 39 (70%) with cognitive impairments. Intervention: Two (n = 28) were to held twice weekly five weeks. The remaining three formed control received usual care, no person specifically responsible...
To investigate the hypothesis that intrinsic changes in sarcoplasmic reticulum (SR) Ca 2+ -sequestration function can be implicated postcontractile depression (PCD) of force humans, muscle tissue was obtained from vastus lateralis and determinations maximal uptake -ATPase activity were made on homogenates before after induction PCD. Eight untrained females, age 20.6 ± 0.75 yr (mean SE), performed a protocol consisting 30 min isometric exercise at 60% voluntary contraction 50% duty cycle (5-s...
Summary The substrates of ion‐ and lipld‐stimulated protein kinase activity in extracts Escherichia coli were purified by chromatography. Subsequent N ‐terminal sequencing suggests that these include the following: a novel 80kDa co‐purifying with RNA polymerase but partially homologous to elongation factor G; an apparent molecular weight 65kDa identified as ribosomal S1; 32 kDa succinyl CoA synthetase, key enzyme tricarboxylic acid cycle. phosphorylation three proteins was markedly...
Grant, S. M., H. J. Green, M. Phillips, D. L. Enns, and R. Sutton. Fluid electrolyte hormonal responses to exercise acute plasma volume expansion. Appl. Physiol. 81(6): 2386–2392, 1996.—To investigate the effect of graded increases in (PV) on fluid regulatory hormone levels, eight untrained men (peak aerobic power 45.2 ± 2.2 ml ⋅ kg −1 min ) performed prolonged cycle (46 4% maximal three occasions, namely, with no PV expansion (Con) after 14% (Low) 21% (High) expansions, respectively. The...
The purpose of this study was to investigate the hypothesis that a single, extended session heavy exercise would be effective in inducing adaptations energy metabolism during absence increases oxidative potential. Ten healthy males [maximal aerobic power (VO(2 peak)) = 43.4 +/- 2.2 (SE) ml x kg(-1) min(-1)] participated 16-h training involving cycling for 6 min each hour at approximately 90% maximal oxygen consumption. Measurements metabolic changes were made on tissue extracted from vastus...
Self-monitoring of hypertension is associated with lower systolic blood pressure (SBP). However, evidence for the use self-monitoring to titrate antihypertensive medication by physicians equivocal. Furthermore, there some efficacy telemonitoring in management but it not clear what this adds over and above self-monitoring. This trial aims evaluate whether GP led titration using results SBP compared usual care anything alone. will be a pragmatic primary based, unblinded, randomised controlled...
Introduction Over 160 000 people with severe hip or knee pain caused by osteoarthritis undergo total (THR) replacement (TKR) surgery each year in the UK within National Health Service (NHS), and this number is expected to increase. Innovative approaches evaluating surgical outcomes will be needed respond increasing burden of joint surgery. The Sensor Platform for Healthcare a Residential Environment, Interdisciplinary Research Collaboration (SPHERE-IRC) have developed system sensors that can...