A5016743095- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Anesthesia and Neurotoxicity Research
- Medicinal Plants and Neuroprotection
- Inflammatory mediators and NSAID effects
- Neurogenesis and neuroplasticity mechanisms
- Estrogen and related hormone effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Hemoglobin structure and function
- Eicosanoids and Hypertension Pharmacology
- Menopause: Health Impacts and Treatments
- Ginkgo biloba and Cashew Applications
- Receptor Mechanisms and Signaling
- Smoking Behavior and Cessation
- Nerve injury and regeneration
San Sebastián University
2016-2024
Bay Pines VA Healthcare System
2015-2024
Veterans Health Administration
2011-2022
United States Department of Veterans Affairs
2011-2022
Universidad Andrés Bello
2018
Universidad Autónoma de Chile
2014-2017
University of South Florida
2008-2016
Pontificia Universidad Javeriana
2016
James A. Haley Veterans' Hospital
2014-2015
Johns Hopkins University
2005-2006
We have recently shown that Alzheimer's disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent 5 cups coffee per day) are protected from development otherwise certain cognitive impairment and decrea
Parkinson's disease (PD) is the second-leading cause of dementia and characterized by a progressive loss dopaminergic neurons in substantia nigra alongside presence intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed restoration system, prevention neuronal cell death midbrain. This review discusses physiological mechanisms involved PD as well new prospective therapies for disease. The current data suggest that or early treatment may be most effective...
Alzheimer's disease (AD) is associated with gliosis, neuroinflammation and higher levels of prostaglandins. Conflicting roles for cyclooxygenases prostaglandins in the etiopathology AD have been reported. We hypothesized that PGE2 signaling through EP2 EP4 G-protein-coupled receptors could protect against amyloid beta-peptide (Abeta) neurotoxicity by increasing cAMP cascade. Using primary neuronal cultures, we investigated presence EP (EP1-4) action receptor agonists on susceptibility to...
Abstract Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 may be involved insofar as it can regulate the of several AD‐related proteins, amyloid precursor protein (APP) and tau. could itself regulated by inflammatory other factors associated with AD, such interleukin‐1β. We measured an almost threefold elevation number mRNA molecules this cytokine AD frontal cortex. was found to up‐regulated these brains (along...
Alzheimer's disease (AD) affects millions of people world-wide and new effective safe therapies are needed. Cotinine, the main metabolite nicotine, has a long half-life does not have cardiovascular or addictive side effects in humans. We studied effect cotinine on amyloid-β (Aβ) aggregation as well addressed its impact working reference memories. Cotinine reduced Aβ deposition, improved memories, inhibited oligomerization brains transgenic (Tg) 6799 AD mice. In vitro studies confirmed...
Testosterone is a hormone that has been shown to confer neuroprotection from different insults affecting the central nervous system (CNS). induces this protection by mechanisms include activation of anti-apoptotic pathways are directly implicated in neuronal survival. However, little attention devoted its actions on glial cells. In present study, we have assessed whether testosterone exerts human astrocyte cell model, T98G Our results indicate improves survival and mitochondrial membrane...
A new group of compounds, promising for the design original multitarget therapeutic agents treating neurodegenerative diseases, based on conjugates aminoadamantane and carbazole derivatives was synthesized investigated. Compounds these series were found to interact with a targets that play an important role in development this type diseases. First all, compounds selectively inhibit butyrylcholinesterase, block NMDA receptors containing NR2B subunits while maintaining properties MK-801...
A greater incidence of tobacco consumption occurs among individuals with psychiatric conditions including post-traumatic stress disorder (PTSD), bipolar disorder, major depression, and schizophrenia, compared the general population. Even when still controversial, it has been postulated that smoking is a form self-medication reduces symptoms these disorders. To better understand component(s) tobacco-inducing behavior, attention directed toward nicotine. However, in recent years, new evidence...