A5047299383- Hepatitis C virus research
- Influenza Virus Research Studies
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Hepatitis B Virus Studies
- interferon and immune responses
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Gastrointestinal Tumor Research and Treatment
- Tumors and Oncological Cases
- Animal Disease Management and Epidemiology
- Head and Neck Anomalies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
National Astronomical Observatory of Japan
2024
Nihon University
2008-2023
Tsuchiura Kyodo General Hospital
1997-2009
University of Lucknow
2006
Ain Shams University
2006
Centro de Innovación de Infraestructuras Inteligentes (Spain)
2006
Osaka University of Pharmaceutical Sciences
2003
Tokyo Medical and Dental University
1973-2001
Saitama Medical University
1978-1996
Josai University
1993
To elucidate the role of class switch recombination (CSR) and somatic hypermutation (SHM) in virus infection, we have investigated influence primary secondary infections influenza on mice deficient activation-induced cytidine deaminase (AID), which is absolutely required for CSR SHM. In AID deficiency caused no significant difference mortality but did cause morbidity. infection with a lethal dose virus, both AID−/− AID+/− survived completely. However, could not completely block replication...
Hepatitis A virus (HAV) infection often causes acute hepatitis, which results in a case fatality rate of 0.2% and fulminant hepatitis 0.5% cases. However, no specific potent anti-HAV drug is available on the market to date. In present study, we focused inhibition HAV internal ribosomal entry site (IRES)-mediated translation investigated novel therapeutic drugs through repurposing by screening for inhibitors IRES-mediated cell viability using reporter assay assay, respectively. The initial...
✓ Three cases of cervical myeloradiculopathy associated with multiple calcified nodules containing identified calcium pyrophosphate dihydrate (CPPD) crystals in the ligamenta flava are described, a comprehensive review 12 this entity reported to date. The disease is characterized by: 1) oval or triangular areas radiodensity posterior aspect canal as seen lateral x-ray films and laminograms; 2) hemispherical high density located almost symmetrically paramedial portion spinal on computerized...
An autopsy case of radiation encephalopathy is reported. This was bilaterally irradiated for epipharyngeal carcinoma with ,60 Go (Total dosis each side: 6020 r/20 fractions /23 days) and taken ill the latent period 2 years after termination irradiation had a clinical course 3 years. The symptoms pathological findings including distribution vascular parenchymal lesions were similar to other cases following hypophysis. From reconstruction serial sections, comparative study sections two...
Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC) worldwide. The integration HBV genomic DNA into the host genome occurs randomly, early after infection, and associated with hepatocarcinogenesis in HBV-infected patients. Therefore, it important to analyze integration. We analyzed human hepatoma PLC/PRF/5 cells by sequence capture-based next-generation sequencing (NGS) methods. confirmed results using Sanger observed that genotype A integrated cells. NGS...
Hepatitis A virus (HAV) is a causative agent of acute hepatitis and can occasionally induce liver failure. However, specific potent anti-HAV drug not available on the market currently. Thus, we investigated several novel therapeutic drugs through repositioning approach, targeting ribonucleic acid (RNA)-dependent RNA polymerase RNA-dependent deoxyribonucleic polymerase. In present study, examined activity 18 by measuring HAV subgenomic replicon HA11-1299 genotype IIIA replication in human...
Amantadine, a nonspecific antiviral medication, also effectively inhibits HAV replication. Autophagy is an important cellular mechanism in several virus-host cell interactions.
Problem Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal also risk schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method study The first trimester trophoblast cell lines, namely, Swan71 HTR8 cells were challenged with A/Udorn/72 virus (H3N2). At indicated time points, examined for expression proteins. Viral replication culture media, apoptosis human leukocyte antigen (HLA)‐G...
We evaluated the anti-influenza-virus effects of Melia components and discuss utility these components. The leaf azedarach L. on viruses were examined, plaque inhibition tests performed. in vivo efficacy M. was tested a mouse model. Leaf markedly inhibited growth various influenza viruses. In an initial screening, multiplication haemagglutination (HA) activities H1N1, H3N2, H5, B inactivated by liquid extract leaves (MLE). Furthermore, titres treated with MLE ranged from 103.7 to 104.2....
To examine interferon (IFN) signaling pathways in human pancreatic cancer cells and their therapeutic application for ductal adenocarcinoma (PDAC).We examined the effects of IFNα on cytotoxicity, migration, as well levels toll-like receptor (TLR) pathway-associated genes expression cells. We also additive poly(I-C) tyrosine kinase inhibitor (TKI)-induced cytotoxicity. performed transcriptome analysis (RNA-Seq) clinical samples compared profile between intraepithelial neoplasias (PanINs)...
Two cases of atypical myeloproliferative disorder with monosomy a group C chromosome are described, which, to our best knowledge, the first report autopsied occurring in siblings. Discussions made mainly on role homeostatic control hematopoiesis, short review previously reported similar or related conditions. Appearance relatively small megakaryocytes, more less decreased amount PAS positive materials their cytoplasm and vague platelet demarcation membrane, is also mentioned, which seemed be...
A 41 year old Japanese woman with lipoprotein glomerulopathy is reported. The patient presented nephrotic syndrome, hyperlipoproteinemia and an increased level of plasma Apo E. damaged glomeruli showed various degrees capillary dilatation accumulation some material often showing stratification, along mesangial proliferation interposition. accumulated was stained positive for β‐ by the indirect immunoperoxidase technique. Capillary resulted from gradual as well destruction mesangium, if being...
Problem Although high maternal mortality was reported in the most recent pandemic of swine‐origin influenza A H 1 N 1/09 ( 1/09), its direct effects on feto‐placental unit are unknown. In present study, we examined susceptibility immortalized human trophoblasts to clinical isolates 2009 1/09) virus. Method study The virus isolated from a patient with influenza, sequenced and identified as / arita/2009 1) strain. trophoblast cell lines Swan71 HTR 8 were challenged for expression viral RNA...
To investigate the presence of tumor-infiltrating lymphocytes (TILs) and CD8-positive (CD8s) in lung cancers to examine prognostic significance their relationship with clinicopathologic parameters.Primary tumor imprint smears from 83 were consecutively obtained at surgery Tsuchiura Kyodo General Hospital between 1996 1998. TILs observed Papanicolaou-stained smears, CD8s immunocytochemically visualized.TILs judged positive 42 cases (51%), 34 (41%) for CD8s. There was no correlation frequency...