A5073332474- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- PARP inhibition in cancer therapy
- Intraperitoneal and Appendiceal Malignancies
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Advanced Electron Microscopy Techniques and Applications
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Ovarian function and disorders
- Uterine Myomas and Treatments
- Viral-associated cancers and disorders
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- BRCA gene mutations in cancer
- Hernia repair and management
- Circular RNAs in diseases
Iwate Medical University
2016-2025
University of Pennsylvania
2017
Cancer Research Center
2017
Philadelphia University
2017
Iwate Prefectural Central Hospital
2001
Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between tumor and effector cells, manipulate local vascular permeability could be translated into effective immunotherapy. Here, we show that in context adoptive cell therapy, antitumor delivered at high enough doses, can overcome endothelial tumors, process requires production C3, complement activation on release C5a. C5a, turn, acts promoting upregulation adhesion molecules...
To evaluate the addition of ofranergene obadenovec (ofra-vec, VB-111), a novel gene-based anticancer targeted therapy, to once week paclitaxel in patients with recurrent platinum-resistant ovarian cancer (PROC).
Abstract Background The quality of life (QOL) ovarian cancer patients is often impaired by refractory ascites. Cell-free and concentrated ascites reinfusion therapy (CART) a palliative treatment for ascites, but adverse events, such as fever, are problematic. Several cytokines have been suggested to be responsible the they not investigated in detail. Thus, we comprehensively analyzed fluid (AF) serum before after CART determine influence on safety efficacy CART. Methods Thirteen with...
Obturator nerve injury is a rare complication of pelvic lymphadenectomy in gynecologic oncology. We report case intraoperative obturator transection and its successful laparoscopic repair. A 73-year-old woman with stage IB1 cervical cancer underwent radical hysterectomy lymphadenectomy. The right was inadvertently transected but successfully repaired laparoscopically using 4-0 polyglactin sutures. Postoperatively, she had mild thigh adduction weakness recovered nearly fully within three...
ABSTRACT A 71‐year‐old woman with POP‐Q stage IV uterine prolapse cystocele underwent robot‐assisted sacrocolpopexy (RSC) using the hinotori Surgical System. During initial surgery, bleeding from median sacral vein led to suboptimal mesh fixation at promontory. Within 1 month post‐surgery, patient experienced recurrence of symptoms. Examination revealed descent cervix nearly pre‐operative state. Robot‐assisted repair surgery was performed, which confirmed detachment site. The involved...
Abstract Background The Proactive Molecular Risk Classifier for Endometrial Cancer has identified four risk groups the prognosis of endometrial cancer. Lenvatinib plus pembrolizumab was recently approved as a second-line treatment unresectable cancer, but reports in clinical practice are lacking. relationship between efficacy lenvatinib/pembrolizumab and classification is unclear. Methods This single-centre retrospective study included patients who underwent therapy at Iwate Medical...
There are no reports on the use of neoadjuvant chemotherapy (NAC) in non-squamous cell cervical carcinoma. We examined effectiveness and safety paclitaxel/carboplatin (TC) docetaxel/carboplatin (DC).Stage Ib2 to IIb disease was present 23 patients scheduled for radical hysterectomy. administered 1-3 courses either TC or DC regimen. Anti-tumor effects were found superior by Response Evaluation Criteria Solid Tumors. Safety assessed with National Cancer Institute Common Terminology Adverse...
Cervical cancer is one of the most common cancers in women. The development new therapies with immune checkpoint inhibitors (ICIs) being investigated for cervical cancer; however, their efficacy not currently sufficient. Oncolytic virus therapy can increase tumor immunogenicity and enhance antitumor effect ICIs. In this report, therapeutic potential a triple-mutated oncolytic herpes (T-01) an ICI human papillomavirus (HPV)-related was evaluated using bilateral syngeneic murine model....
The prognosis of gynecological malignancies has improved with the recent advent molecularly targeted drugs and immune checkpoint inhibitors. However, these are expensive contribute to increasing costs medical care.
We examined the efficacy and safety of neoadjuvant chemotherapy (NAC) with CPT-11 + CDDP regimen in combination radical hysterectomy. The subjects were 42 patients stages IB2 to IIIB squamous cell carcinoma uterine cervix a bulky mass. at 70 mg/m2 was intravenously administered on day 1 days 8 21-day cycle. In principle, two cycles followed by antitumor efficacy, adverse events, completion rate hysterectomy, operative time, surgical blood loss, progression-free survival (PFS), overall (OS)....
The aim of the present study was to evaluate oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated fertility-sparing surgery (FSS). Women aged ≤40 years EOC who had undergone FSS between 2000 2010 were retrospectively reviewed. Survival examined using Kaplan-Meier method statistical significance analyzed log-rank test. A total 29 (stage IA, n=14; IC1 n=6; IC3, n=9) from seven participating institutions belonging Tohoku Gynecologic Cancer...
Abstract BRCA1/2 mutations are robust biomarkers for platinum-based chemotherapy in epithelial ovarian cancers. However, clear cell carcinoma (CCC) less frequent compared with high-grade serous cancer (HGSC). The discovery of that can be applied to CCC is an unmet need chemotherapy. Schlafen 11 (SLFN11) has attracted attention as a novel sensitizer DNA-damaging agents including platinum. In this study, we investigated the utility SLFN11 HGSC and expression was analyzed retrospectively by IHC...
Serous carcinoma of the uterus (USC) is a pathological subtype high-grade endometrial cancers, with no effective treatment for advanced cases. Since such refractory tumors frequently harbor antitumor immune tolerance, many immunotherapies have been investigated various malignant using immuno-competent animal models mimicking their local immunities. In this study, we established an orthotopic mouse model cancer and evaluated tumor immunity to explore efficacy against USC. A multivariate...
Background/Aim: Ovarian cancer diagnosed with platinum-resistant recurrence has very poor prognosis and single-agent chemotherapy no cross-resistance to prior is recommended for its treatment. In this study, we retrospectively evaluated the efficacy safety of platinum rechallenge therapy once ovarian who had a platinum-free interval (PFI) at least 6 months. Patients Methods: The study included 49 patients received ovarian, fallopian tube or primary peritoneal were between January 2010 March...
The present study aimed to assess the antitumor response and safety of a tri-weekly neoadjuvant chemotherapy regimen consisting cisplatin irinotecan for treatment locally advanced cervical cancer with bulky mass. Between June 2002 March 2008, 20 patients squamous cell carcinoma uterine cervix at clinical stage Ib2-IIIb were studied. Two 21-day cycles intravenous administration 70 mg/m(2) (Day 1) (Days 1 8) performed. Antitumor responses, adverse events surgery completion rate investigated....